8YYM: Cylindrical fiber of MyD88 TIR

Cryo-EM structure of cylindrical fiber of MyD88 TIR. Determined by electron microscopy at 3.3 Å resolution. Released 26 Mar 2025.

Method
Electron microscopy
Resolution
3.3 Å
Organism
Homo sapiens
Chains
104
Atoms
115,856
Mol. weight
1751.54 kDa
Released
26 Mar 2025

Explore 8YYM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8YYM contains 936 α-helices and 728 β-strands across 104 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, AA, AB, AC, B, BA, BB, BC, C, CA, CB, CC, D, DA, DB, DC, E, EA, EB, EC, F, FA, FB, FC, G, GA, GB, GC, H, HA, HB, HC, I, IA, IB, IC, J, JA, JB, JC, K, KA, KB, KC, L, LA, LB, LC, M, MA, MB, MC, N, NA, NB, NC, O, OA, OB, OC, P, PA, PB, PC, Q, QA, QB, QC, R, RA, RB, RC, S, SA, SB, SC, T, TA, TB, TC, U, UA, UB, UC, V, VA, VB, VC, W, WA, WB, WC, X, XA, XB, XC, Y, YA, YB, YC, Z, ZA, ZB and ZC: 9 helices, 7 β-strands

ElementResiduesLengthSheet
β-strand163-16641
α-helix172-18211
β-strand191-19221
α-helix194-1974
β-strand20312
α-helix204-2063
α-helix207-2159
β-strand218-22361
α-helix226-2283
α-helix232-24110
β-strand253-25641
α-helix263-2653
α-helix266-2683
β-strand27113
β-strand274-27521
α-helix285-2939

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Myeloid differentiation primary response protein MyD88A, AA, AB, AC, B, BA, BB, BC, C, CA, CB, CC, D, DA, DB, DC, E, EA, EB, EC, F, FA, FB, FC, G, GA, GB, GC, H, HA, HB, HC, I, IA, IB, IC, J, JA, JB, JC, K, KA, KB, KC, L, LA, LB, LC, M, MA, MB, MC, N, NA, NB, NC, O, OA, OB, OC, P, PA, PB, PC, Q, QA, QB, QC, R, RA, RB, RC, S, SA, SB, SC, T, TA, TB, TC, U, UA, UB, UC, V, VA, VB, VC, W, WA, WB, WC, X, XA, XB, XC, Y, YA, YB, YC, Z, ZA, ZB, ZCprotein144Homo sapiensQ99836 (AlphaFold model)
Sequence of entity 1 (A, AA, AB, AC, B, BA, BB, BC, C, CA, CB, CC, D, DA, DB, DC, E, EA, EB, EC, F, FA, FB, FC, G, GA, GB, GC, H, HA, HB, HC, I, IA, IB, IC, J, JA, JB, JC, K, KA, KB, KC, L, LA, LB, LC, M, MA, MB, MC, N, NA, NB, NC, O, OA, OB, OC, P, PA, PB, PC, Q, QA, QB, QC, R, RA, RB, RC, S, SA, SB, SC, T, TA, TB, TC, U, UA, UB, UC, V, VA, VB, VC, W, WA, WB, WC, X, XA, XB, XC, Y, YA, YB, YC, Z, ZA, ZB, ZC), FASTA
>8YYM_1 Myeloid differentiation primary response protein MyD88 (chains A, AA, AB, AC, B, BA, BB, BC, C, CA, CB, CC, D, DA, DB, DC, E, EA, EB, EC, F, FA, FB, FC, G, GA, GB, GC, H, HA, HB, HC, I, IA, IB, IC, J, JA, JB, JC, K, KA, KB, KC, L, LA, LB, LC, M, MA, MB, MC, N, NA, NB, NC, O, OA, OB, OC, P, PA, PB, PC, Q, QA, QB, QC, R, RA, RB, RC, S, SA, SB, SC, T, TA, TB, TC, U, UA, UB, UC, V, VA, VB, VC, W, WA, WB, WC, X, XA, XB, XC, Y, YA, YB, YC, Z, ZA, ZB, ZC)
PLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELI
EKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFIT
VCDYTNPCTKSWFWTRLAKALSLP

Primary citation

Structural Mechanism of Receptor-Triggered MyD88 Oligomeric Assembly in Innate Immune Signaling. Kasai, K., Imamura, K., Uno, M. et al. Nat Commun (2026). DOI 10.1038/s41467-026-71836-8 · PubMed

Other PDB entries of the same protein (UniProt Q99836 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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