Cryo-EM structure of importin alpha-1/beta bound to TDP-43. Determined by electron microscopy at 3.74 Å resolution. Released 26 Mar 2025.
Explore 9B4Y in 3D Show helices and sheets RCSB PDB PDBe
9B4Y contains 54 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 3-9 | 7 | |
| α-helix | 15-31 | 17 | |
| α-helix | 33-45 | 13 | |
| α-helix | 51-65 | 15 | |
| α-helix | 70-81 | 12 | |
| α-helix | 85-98 | 14 | |
| α-helix | 108-123 | 16 | |
| α-helix | 129-138 | 10 | |
| α-helix | 144-160 | 17 | |
| α-helix | 163-166 | 4 | |
| α-helix | 170-179 | 10 | |
| α-helix | 188-200 | 13 | |
| α-helix | 206-209 | 4 | |
| α-helix | 212-225 | 14 | |
| α-helix | 231-247 | 17 | |
| α-helix | 249-251 | 3 | |
| α-helix | 253-255 | 3 | |
| α-helix | 256-260 | 5 | |
| α-helix | 261-268 | 8 | |
| α-helix | 273-303 | 31 | |
| α-helix | 306-307 | 2 | |
| α-helix | 319-329 | 11 | |
| α-helix | 344-359 | 16 | |
| α-helix | 364-374 | 11 | |
| α-helix | 380-392 | 13 | |
| α-helix | 399-416 | 18 | |
| α-helix | 422-438 | 17 | |
| α-helix | 440-443 | 4 | |
| α-helix | 446-459 | 14 | |
| α-helix | 464-488 | 25 | |
| α-helix | 500-513 | 14 | |
| α-helix | 521-523 | 3 | |
| α-helix | 524-537 | 14 | |
| α-helix | 541-543 | 3 | |
| α-helix | 544-562 | 19 | |
| α-helix | 571-592 | 22 | |
| α-helix | 597-617 | 21 | |
| α-helix | 622-639 | 18 | |
| α-helix | 643-645 | 3 | |
| α-helix | 651-658 | 8 | |
| α-helix | 664-681 | 18 | |
| α-helix | 682-685 | 4 | |
| α-helix | 686-701 | 16 | |
| α-helix | 709-724 | 16 | |
| α-helix | 729-744 | 16 | |
| α-helix | 752-777 | 26 | |
| α-helix | 785-788 | 4 | |
| α-helix | 794-806 | 13 | |
| α-helix | 812-828 | 17 | |
| α-helix | 831-838 | 8 | |
| α-helix | 842-852 | 11 | |
| α-helix | 856-873 | 18 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 14-16 | 3 | |
| α-helix | 24-51 | 28 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Importin subunit beta-1 | A | protein | 876 | Homo sapiens | Q14974 (AlphaFold model) |
| Importin subunit alpha-1 | B | protein | 43 | Homo sapiens | P52292 (AlphaFold model) |
>9B4Y_1 Importin subunit beta-1 (chains A) MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLHTLGTETYRPSSASQCVAGIACAE IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR PMIHELLTEGRRSKTNKAKTLARWATKELRKLKNQA
>9B4Y_2 Importin subunit alpha-1 (chains B) AARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNV
Single Acetylation-mimetic Mutation in TDP-43 Nuclear Localization Signal Disrupts Importin alpha 1/ beta Signaling. Ko, Y.H., Lokareddy, R.K., Doll, S.G. et al. J Mol Biol (2024) 436:168751-168751. DOI 10.1016/j.jmb.2024.168751 · PubMed
Other PDB entries of the same protein (UniProt Q14974 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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