9C5S: Cellular tumor antigen p53

Disulfide-linked, antiparallel p53-derived peptide dimer (CV1). Determined by X-ray diffraction at 1.01 Å resolution. Released 26 Jun 2024.

Method: X-ray diffraction
Resolution: 1.01 Å
Organism: Homo sapiens
Chains: 4
Atoms: 548
Mol. weight: 6.81 kDa
Released: 26 Jun 2024

Explore 9C5S in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9C5S contains 4 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-13	11

Chains B and C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-11	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cellular tumor antigen p53	A, B, C, D	protein	16	Homo sapiens	P04637 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>9C5S_1 Cellular tumor antigen p53 (chains A, B, C, D)
XCTFANLWRLLAQNCX

Primary citation

Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers. DiGiorno, M.C., Vithanage, N., Victorio, C.G. et al. Res Sq (2024). DOI 10.21203/rs.3.rs-4644285/v1 · PubMed

Other PDB entries of the same protein (UniProt P04637 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3D06 1.2 Å, Human p53 core domain with hot spot mutation R249S (I)
5MHC 1.2 Å, Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
8UQR 1.22 Å, Crystal structure of the human p53 tetramerization domain
6GGC 1.24 Å, p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9320
6SHZ 1.24 Å, p53 cancer mutant Y220C
4MZI 1.25 Å, Crystal structure of a human mutant p53
6GGE 1.25 Å, p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327
3LW1 1.28 Å, Binary complex of 14-3-3 sigma and p53 pT387-peptide
5O1E 1.3 Å, p53 cancer mutant Y220C im complex with compound MB577
6RL3 1.3 Å, Fragment AZ-003 binding at the p53pT387/14-3-3 sigma interface
8E7A 1.3 Å, Crystal structure of the p53 (Y107H) core domain orthorhombic P form
5O1C 1.32 Å, p53 cancer mutant Y220C in complex with compound MB184

Browse structure collections

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