9C62: RuvB-like 2

P400 subcomplex of the native human TIP60 complex. Determined by electron microscopy at 5.28 Å resolution. Released 21 Aug 2024.

Method: Electron microscopy
Resolution: 5.28 Å
Organism: Homo sapiens
Chains: 15
Atoms: 39,452
Mol. weight: 1002.69 kDa
Ligands: ADP
Released: 21 Aug 2024

Explore 9C62 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9C62 contains 252 α-helices and 239 β-strands across 15 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 25 β-strands

Element	Residues	Length	Sheet
α-helix	13-14	2
β-strand	15	1	4
β-strand	26	1	75
α-helix	31	1
β-strand	32	1	75
α-helix	33	1
β-strand	35-36	2	76
β-strand	39-40	2	76
α-helix	43-58	16
β-strand	61	1	39
β-strand	65-69	5	77
α-helix	76-87	12
β-strand	93-96	4	77
α-helix	99-101	3
α-helix	108-119	12
β-strand	121-126	6	78
β-strand	157	1	79
β-strand	170	1	79
α-helix	174-181	8
β-strand	191	1	80
β-strand	202	1	80
β-strand	234-239	6	78
α-helix	240-248	9
α-helix	256-261	6
α-helix	265-266	2
α-helix	270-272	3
α-helix	273-288	16
β-strand	292-295	4	78
β-strand	298-301	4	77
α-helix	304-306	3
β-strand	308	1	81
α-helix	309-320	12
α-helix	324-325	2
β-strand	326-331	6	77
β-strand	333	1	47
β-strand	336-337	2	82
α-helix	338	1
β-strand	339	1	81
β-strand	345-346	2	82
α-helix	347-349	3
α-helix	352-356	5
β-strand	359-362	4	77
α-helix	368-382	15
β-strand	386	1	83
α-helix	388-401	14
α-helix	403-408	6
α-helix	410-419	10
β-strand	425	1	83
α-helix	427-436	10
α-helix	440-447	8

Chain B: 17 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	1
β-strand	33	1	2
β-strand	39	1	2
β-strand	42-43	2	3
β-strand	46-47	2	3
α-helix	50-65	16
β-strand	68	1	4
β-strand	72-75	4	5
α-helix	83-94	12
β-strand	102-103	2	5
α-helix	106-108	3
α-helix	115-126	12
β-strand	129-133	5	6
β-strand	163	1	7
β-strand	170	1	7
α-helix	177-182	6
β-strand	238-242	5	6
α-helix	244-252	9
α-helix	256-262	7
α-helix	270-286	17
β-strand	290-291	2	6
β-strand	295-298	4	5
α-helix	301-303	3
β-strand	305	1	8
α-helix	306-316	11
β-strand	323-325	3	5
β-strand	332-334	3	9
α-helix	335	1
β-strand	336	1	8
β-strand	341-343	3	9
α-helix	348-352	5
β-strand	355-357	3	5
α-helix	364-377	14
β-strand	382	1	10
α-helix	384-396	13
α-helix	399-416	18
β-strand	421	1	10
α-helix	423-432	10
α-helix	436-445	10
β-strand	451	1	11

Chain C: 22 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	12
α-helix	17-19	3
β-strand	26	1	13
β-strand	32	1	13
β-strand	36	1	14
β-strand	39	1	14
α-helix	43-58	16
β-strand	61	1	1
β-strand	65	1	15
β-strand	68	1	16
α-helix	76-86	11
β-strand	93-97	5	15
α-helix	99-101	3
α-helix	108-119	12
β-strand	121-125	5	17
β-strand	130-140	11	18
β-strand	156	1	19
β-strand	157-163	7	18
β-strand	166-170	5	18
β-strand	172	1	19
α-helix	174-183	10
β-strand	189-194	6	18
β-strand	200-206	7	18
β-strand	220-221	2	18
α-helix	222-224	3
β-strand	229-230	2	18
β-strand	235-238	4	17
α-helix	240-248	9
α-helix	256-263	8
α-helix	270-272	3
α-helix	273-288	16
β-strand	293-295	3	17
β-strand	298-302	5	15
α-helix	304-306	3
α-helix	309-318	10
β-strand	326-328	3	15
β-strand	333	1	11
β-strand	336-337	2	20
α-helix	338	1
β-strand	345-346	2	20
α-helix	347-349	3
α-helix	352-355	4
β-strand	361	1	16
α-helix	368-382	15
β-strand	386	1	21
α-helix	388-400	13
α-helix	403-408	6
α-helix	410-419	10
β-strand	425	1	21
α-helix	427-436	10
α-helix	440-446	7

Chain D: 25 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	33	1	22
α-helix	38	1
β-strand	39	1	22
α-helix	40	1
α-helix	50-65	16
β-strand	68	1	12
β-strand	72-77	6	23
α-helix	83-94	12
β-strand	100-104	5	23
α-helix	105-108	4
α-helix	115-126	12
β-strand	128-134	7	24
β-strand	137-148	12	25
β-strand	158-164	7	25
β-strand	169-173	5	25
α-helix	176-185	10
α-helix	187-188	2
β-strand	192-196	5	25
β-strand	202-204	3	25
α-helix	209-213	5
α-helix	226-228	3
β-strand	237-243	7	24
α-helix	244-252	9
α-helix	259-262	4
α-helix	270-284	15
β-strand	289-292	4	24
β-strand	295-299	5	23
α-helix	301-303	3
α-helix	306-315	10
β-strand	323-327	5	23
β-strand	333-334	2	26
α-helix	335	1
β-strand	341-342	2	26
α-helix	343-345	3
α-helix	348-351	4
β-strand	355-359	5	23
α-helix	360-362	3
α-helix	365-378	14
α-helix	384-397	14
α-helix	399-416	18
α-helix	423-432	10
α-helix	436-445	10
α-helix	447-449	3
β-strand	451	1	27

Chain E: 25 helices, 27 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	28
α-helix	16	1
β-strand	26	1	29
α-helix	31	1
β-strand	32	1	29
α-helix	33	1
α-helix	43-58	16
β-strand	65-69	5	30
α-helix	76-87	12
β-strand	93-94	2	30
β-strand	97	1	31
α-helix	98-101	4
α-helix	108-118	11
β-strand	120-127	8	32
β-strand	131	1	33
β-strand	134-142	9	34
β-strand	153-162	10	34
β-strand	167-172	6	34
α-helix	174-182	9
β-strand	189-191	3	35
β-strand	193	1	33
β-strand	202-205	4	35
β-strand	206	1	36
α-helix	207-212	6
β-strand	221	1	36
β-strand	233-239	7	32
α-helix	240-248	9
α-helix	256-263	8
α-helix	265-266	2
α-helix	273-288	16
β-strand	292-296	5	32
β-strand	298-301	4	30
β-strand	302	1	31
α-helix	304-306	3
α-helix	309-320	12
α-helix	324-325	2
β-strand	326-331	6	30
β-strand	333	1	27
β-strand	335-337	3	37
α-helix	338	1
β-strand	345-347	3	37
α-helix	352-356	5
β-strand	361-362	2	30
α-helix	368-382	15
β-strand	386	1	38
α-helix	388-400	13
α-helix	403-408	6
α-helix	410-420	11
β-strand	425	1	38
α-helix	427-436	10
α-helix	440-447	8

Chain F: 17 helices, 24 β-strands

Element	Residues	Length	Sheet
α-helix	16-18	3
β-strand	22	1	39
β-strand	42-43	2	40
β-strand	46-47	2	40
α-helix	50-65	16
β-strand	68	1	28
β-strand	72-75	4	41
α-helix	83-94	12
β-strand	100-104	5	41
α-helix	115-126	12
β-strand	128-134	7	42
β-strand	137-142	6	43
β-strand	144	1	44
β-strand	161	1	44
β-strand	163	1	43
α-helix	176-184	9
β-strand	191-195	5	43
β-strand	202-203	2	43
β-strand	233-234	2	43
β-strand	237-241	5	42
α-helix	244-252	9
α-helix	256-262	7
α-helix	270-286	17
β-strand	289-292	4	42
β-strand	295-299	5	41
α-helix	301-303	3
α-helix	306-317	12
β-strand	324-325	2	41
β-strand	332-334	3	45
β-strand	341-343	3	45
α-helix	348-351	4
β-strand	354-357	4	41
α-helix	364-378	15
β-strand	382	1	46
α-helix	384-396	13
α-helix	399-415	17
β-strand	421	1	46
α-helix	422	1
α-helix	423-432	10
α-helix	436-446	11
β-strand	451	1	47

Chain G: 36 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	777-792	16
α-helix	811-908	98
α-helix	1059-1067	9
α-helix	1071-1074	4
α-helix	1093-1107	15
β-strand	1112-1114	3	48
α-helix	1116-1117	2
α-helix	1122-1132	11
β-strand	1146	1	48
α-helix	1152-1162	11
β-strand	1168	1	49
α-helix	1175-1183	9
β-strand	1193	1	49
β-strand	1196	1	48
α-helix	1199-1203	5
α-helix	1205-1207	3
β-strand	1213	1	50
β-strand	1216-1218	3	48
α-helix	1221-1223	3
α-helix	1229-1236	8
β-strand	1240	1	50
β-strand	1243-1246	4	48
α-helix	1255-1265	11
α-helix	1283-1300	18
α-helix	1301-1303	3
α-helix	1309-1312	4
β-strand	1319	1	51
α-helix	1330-1339	10
α-helix	1343-1351	9
α-helix	1354-1357	4
α-helix	1360-1369	10
β-strand	1383-1385	3	52
α-helix	1386-1387	2
β-strand	1389-1390	2	53
α-helix	1395-1398	4
α-helix	1439-1444	6
α-helix	1742-1757	16
α-helix	1826-1831	6
β-strand	1838-1840	3	52
α-helix	1841-1843	3
β-strand	1844-1845	2	53
α-helix	1852-1868	17
α-helix	1870-1878	9
α-helix	1890-1892	3
α-helix	1893-1896	4
α-helix	1898-1913	16
β-strand	1917-1921	5	54
α-helix	1924-1937	14
α-helix	1950-1962	13
β-strand	1968-1972	5	54
β-strand	2016	1	51
α-helix	2030-2033	4
α-helix	2189-2216	28
β-strand	2222-2224	3	55
β-strand	2247-2248	2	55

Chain H: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	441	1	55
β-strand	444	1	56
β-strand	451	1	56
β-strand	455-460	6	55
α-helix	461-463	3
β-strand	464-469	6	55
α-helix	475-477	3

7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RuvB-like 2	B, D, F	protein	463	Homo sapiens	Q9Y230 (AlphaFold model)
RuvB-like 1	A, C, E	protein	456	Homo sapiens	Q9Y265 (AlphaFold model)
E1A-binding protein p400	G	protein	3159	Homo sapiens	Q96L91
Enhancer of polycomb homolog 1	H	protein	836	Homo sapiens	Q9H2F5 (AlphaFold model)
DNA methyltransferase 1-associated protein 1	I	protein	467	Homo sapiens	Q9NPF5
Actin, cytoplasmic 1	J	protein	375	Homo sapiens	P60709
Vacuolar protein sorting-associated protein 72 homolog	K	protein	364	Homo sapiens	Q15906
Actin-like protein 6A	L, M	protein	429	Homo sapiens	O96019
Histone H2A.Z	N	protein	128	Homo sapiens	P0C0S5
Histone H2B type 1-B	O	protein	126	Homo sapiens	P33778

Sequence of entity 1 (B, D, F), FASTA

>9C62_1 RuvB-like 2 (chains B, D, F)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS

Sequence of entity 2 (A, C, E), FASTA

>9C62_2 RuvB-like 1 (chains A, C, E)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK

Sequence of entity 3 (G), FASTA

>9C62_3 E1A-binding protein p400 (chains G)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQP
FQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGV
PLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPA
GVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALH
VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR
SSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQ
VHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKL
VRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKR
KKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEE
ANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP
GDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK
FNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW
GPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQ
FFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWT
MVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKY
EHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG
SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLM
EEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQG
PLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTA
QASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA
QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTV
SQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQE
EKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPA
HSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRI
LRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLIL
SQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGI
NLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLI
REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIA
RPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLT
PIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAEL
LTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKL
PPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNIL
LKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPN
WDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQL
YTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAE
RIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQP
QPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIA
GVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATT
QGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM
QKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVA
NLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAG
ISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQI
TTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASI
QQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTP
GAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ

Sequence of entity 4 (H), FASTA

>9C62_4 Enhancer of polycomb homolog 1 (chains H)
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIP
IIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAA
LPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQT
GNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHH
LDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSD
NDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQK
QQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSKTLDSASAQFAA
SALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALL
QPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRT
LSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT

Sequence of entity 5 (I), FASTA

>9C62_5 DNA methyltransferase 1-associated protein 1 (chains I)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP

Sequence of entity 6 (J), FASTA

>9C62_6 Actin, cytoplasmic 1 (chains J)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Sequence of entity 7 (K), FASTA

>9C62_7 Vacuolar protein sorting-associated protein 72 homolog (chains K)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK

Sequence of entity 8 (L, M), FASTA

>9C62_8 Actin-like protein 6A (chains L, M)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP

Sequence of entity 9 (N), FASTA

>9C62_9 Histone H2A.Z (chains N)
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILE
YLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIG
KKGQQKTV

Sequence of entity 10 (O), FASTA

>9C62_10 Histone H2B type 1-B (chains O)
MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	6

Primary citation

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Yang, Z., Mameri, A., Cattoglio, C. et al. Science (2024) 385:eadl5816-eadl5816. DOI 10.1126/science.adl5816 · PubMed

Other PDB entries of the same protein (UniProt Q9Y230 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8QR1 2.4 Å, Cryo-EM structure of the human Tip60 complex
9EMA 2.4 Å, RUVBL1/2 in complex with ATP and CB-6644 inhibitor
6K0R 2.5 Å, Ruvbl1-Ruvbl2 with truncated domain II in complex with phosphorylated Cordycepin
9C57 2.75 Å, Reconstituted P400 Subcomplex of the human TIP60 complex
6H7X 2.89 Å, First X-ray structure of full-length human RuvB-Like 2.
3UK6 2.95 Å, Crystal Structure of the Tip48 (Tip49b) hexamer
2XSZ 3.0 Å, The dodecameric human RuvBL1:RuvBL2 complex with truncated domains II
9CAE 3.07 Å, Cryo-EM structure of the reconstituted RuvBL lobe of the human TIP60 complex (composite…
7ZI4 3.2 Å, Cryo-EM structure of the human INO80 complex bound to a WT nucleosome
8X15 3.2 Å, Structure of nucleosome-bound SRCAP-C in the apo state
8X19 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state
8X1C 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-bound state

Browse structure collections

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