9E23: Pre-Chi dynein tail
Cryo-EM structure of Pre-Chi dynein tail. Determined by electron microscopy at 6.2 Å resolution. Released 9 Jul 2025.
- Method
- Electron microscopy
- Resolution
- 6.2 Å
- Organism
- Homo sapiens
- Chains
- 16
- Atoms
- 21,249
- Mol. weight
- 2666.18 kDa
- Released
- 9 Jul 2025
Explore 9E23 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9E23 contains 174 α-helices and 153 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 9 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-41 | 14 | |
| α-helix | 50-57 | 8 | |
| α-helix | 59-70 | 12 | |
| β-strand | 78-80 | 3 | 40 |
| β-strand | 84 | 1 | 41 |
| β-strand | 98 | 1 | 41 |
| β-strand | 115-119 | 5 | 40 |
| α-helix | 132-134 | 3 | |
| β-strand | 136-139 | 4 | 40 |
| α-helix | 140-141 | 2 | |
| α-helix | 145-152 | 8 | |
| α-helix | 153-157 | 5 | |
| α-helix | 158-167 | 10 | |
| α-helix | 179-197 | 19 | |
Chain B: 17 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-47 | 20 | |
| β-strand | 54-59 | 6 | 25 |
| α-helix | 61-62 | 2 | |
| α-helix | 68-74 | 7 | |
| β-strand | 87-89 | 3 | 25 |
| β-strand | 104-108 | 5 | 25 |
| α-helix | 113-115 | 3 | |
| α-helix | 116-122 | 7 | |
| β-strand | 133-134 | 2 | 25 |
| α-helix | 142-163 | 22 | |
| α-helix | 167-182 | 16 | |
| β-strand | 227-228 | 2 | 26 |
| α-helix | 234-236 | 3 | |
| α-helix | 237-238 | 2 | |
| α-helix | 239-243 | 5 | |
| α-helix | 248-265 | 18 | |
| β-strand | 267-268 | 2 | 26 |
| α-helix | 280-290 | 11 | |
| α-helix | 298-300 | 3 | |
| β-strand | 301 | 1 | 27 |
| β-strand | 309 | 1 | 27 |
| α-helix | 317-323 | 7 | |
| α-helix | 324-326 | 3 | |
| α-helix | 356-358 | 3 | |
| α-helix | 359-372 | 14 | |
Chain C: 16 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-43 | 16 | |
| α-helix | 44-47 | 4 | |
| α-helix | 67-75 | 9 | |
| β-strand | 89-90 | 2 | 28 |
| β-strand | 93 | 1 | 29 |
| β-strand | 102 | 1 | 29 |
| β-strand | 105-106 | 2 | 28 |
| α-helix | 113-115 | 3 | |
| α-helix | 118-122 | 5 | |
| β-strand | 133 | 1 | 30 |
| α-helix | 142-163 | 22 | |
| α-helix | 167-183 | 17 | |
| β-strand | 227 | 1 | 30 |
| β-strand | 231 | 1 | 31 |
| α-helix | 237-242 | 6 | |
| α-helix | 248-265 | 18 | |
| β-strand | 270 | 1 | 32 |
| β-strand | 271 | 1 | 31 |
| α-helix | 280-287 | 8 | |
| α-helix | 288-292 | 5 | |
| α-helix | 299-300 | 2 | |
| β-strand | 309 | 1 | 32 |
| α-helix | 310-311 | 2 | |
| α-helix | 317-324 | 8 | |
| α-helix | 336-339 | 4 | |
| α-helix | 359-372 | 14 | |
Chain d: 2 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 13 | 1 | 16 |
| α-helix | 15-31 | 17 | |
| α-helix | 35-49 | 15 | |
| β-strand | 57 | 1 | 17 |
| β-strand | 59 | 1 | 18 |
| β-strand | 72 | 1 | 16 |
| β-strand | 78 | 1 | 19 |
| β-strand | 81 | 1 | 19 |
| β-strand | 84 | 1 | 17 |
Chain D: 6 helices, 35 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 185-191 | 7 | |
| α-helix | 194-211 | 18 | |
| α-helix | 228-231 | 4 | |
| β-strand | 240-241 | 2 | 45 |
| β-strand | 245 | 1 | 46 |
| α-helix | 248-251 | 4 | |
| β-strand | 254-261 | 8 | 47 |
| β-strand | 268-276 | 9 | 47 |
| β-strand | 285 | 1 | 48 |
| β-strand | 288-291 | 4 | 47 |
| β-strand | 305 | 1 | 48 |
| β-strand | 309-313 | 5 | 49 |
| β-strand | 321-326 | 6 | 49 |
| β-strand | 331-335 | 5 | 49 |
| β-strand | 345 | 1 | 49 |
| β-strand | 360-362 | 3 | 50 |
| β-strand | 371 | 1 | 51 |
| β-strand | 373-375 | 3 | 50 |
| β-strand | 380 | 1 | 52 |
| β-strand | 385 | 1 | 51 |
| β-strand | 397 | 1 | 52 |
| β-strand | 408-410 | 3 | 53 |
| β-strand | 420-425 | 6 | 53 |
| β-strand | 430-434 | 5 | 53 |
| β-strand | 441-442 | 2 | 53 |
| β-strand | 446 | 1 | 53 |
| β-strand | 453-457 | 5 | 54 |
| β-strand | 470-475 | 6 | 54 |
| β-strand | 479-484 | 6 | 54 |
| β-strand | 490-494 | 5 | 54 |
| β-strand | 503-506 | 4 | 55 |
| β-strand | 514-517 | 4 | 55 |
| β-strand | 522 | 1 | 56 |
| β-strand | 523-524 | 2 | 55 |
| β-strand | 540 | 1 | 56 |
| α-helix | 545-547 | 3 | |
| β-strand | 552 | 1 | 45 |
| β-strand | 558-560 | 3 | 45 |
| β-strand | 568 | 1 | 46 |
| β-strand | 570-572 | 3 | 45 |
| α-helix | 582-607 | 26 | |
Chain e: 50 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 211-223 | 13 | |
| α-helix | 225-227 | 3 | |
| α-helix | 234-237 | 4 | |
| α-helix | 239-260 | 22 | |
| α-helix | 271-293 | 23 | |
| α-helix | 295-306 | 12 | |
| α-helix | 310-318 | 9 | |
| α-helix | 322-330 | 9 | |
| α-helix | 341-346 | 6 | |
| α-helix | 350-369 | 20 | |
| α-helix | 374-399 | 26 | |
| α-helix | 401-403 | 3 | |
| α-helix | 406-440 | 35 | |
| α-helix | 457-479 | 23 | |
| α-helix | 480-484 | 5 | |
| α-helix | 514-532 | 19 | |
| α-helix | 540-574 | 35 | |
| α-helix | 578-588 | 11 | |
| α-helix | 597-624 | 28 | |
| α-helix | 631-639 | 9 | |
| α-helix | 643-669 | 27 | |
| α-helix | 673-675 | 3 | |
| α-helix | 677-692 | 16 | |
| α-helix | 696-709 | 14 | |
| β-strand | 720-725 | 6 | 33 |
| β-strand | 728-735 | 8 | 33 |
| α-helix | 741-756 | 16 | |
| α-helix | 762-797 | 36 | |
| α-helix | 799-805 | 7 | |
| α-helix | 806-821 | 16 | |
| α-helix | 829-865 | 37 | |
| α-helix | 871-891 | 21 | |
| α-helix | 896-926 | 31 | |
| α-helix | 975-994 | 20 | |
| β-strand | 997 | 1 | 34 |
| α-helix | 998 | 1 | |
| α-helix | 1001-1003 | 3 | |
| α-helix | 1009-1010 | 2 | |
| α-helix | 1014-1017 | 4 | |
| β-strand | 1018 | 1 | 34 |
| α-helix | 1021-1024 | 4 | |
| α-helix | 1031-1055 | 25 | |
| α-helix | 1058-1062 | 5 | |
| α-helix | 1065-1072 | 8 | |
| α-helix | 1076-1091 | 16 | |
| β-strand | 1101-1102 | 2 | 35 |
| β-strand | 1105-1106 | 2 | 35 |
| α-helix | 1109-1155 | 47 | |
| α-helix | 1163-1199 | 37 | |
| α-helix | 1203-1205 | 3 | |
| α-helix | 1211-1263 | 53 | |
| α-helix | 1272-1304 | 33 | |
| α-helix | 1314-1348 | 35 | |
| α-helix | 1356-1370 | 15 | |
| α-helix | 1375-1379 | 5 | |
| α-helix | 1381-1403 | 23 | |
Chain E: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-12 | 10 | |
| β-strand | 22-23 | 2 | 1 |
| α-helix | 36-60 | 25 | |
| β-strand | 68 | 1 | 2 |
| β-strand | 69-71 | 3 | 3 |
| β-strand | 78-80 | 3 | 3 |
| β-strand | 87-88 | 2 | 1 |
Chain f: 48 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 211-223 | 13 | |
| α-helix | 225-226 | 2 | |
| α-helix | 229-232 | 4 | |
| α-helix | 234-237 | 4 | |
| α-helix | 239-261 | 23 | |
| α-helix | 271-293 | 23 | |
| α-helix | 295-306 | 12 | |
| α-helix | 310-320 | 11 | |
| α-helix | 322-336 | 15 | |
| α-helix | 340-346 | 7 | |
| α-helix | 350-369 | 20 | |
| α-helix | 374-399 | 26 | |
| α-helix | 406-440 | 35 | |
| α-helix | 457-484 | 28 | |
| α-helix | 514-532 | 19 | |
| α-helix | 540-574 | 35 | |
| α-helix | 578-588 | 11 | |
| α-helix | 595-597 | 3 | |
| α-helix | 598-624 | 27 | |
| α-helix | 631-638 | 8 | |
| α-helix | 643-669 | 27 | |
| α-helix | 677-692 | 16 | |
| α-helix | 695-709 | 15 | |
| β-strand | 719-723 | 5 | 36 |
| α-helix | 724-725 | 2 | |
| β-strand | 732-736 | 5 | 36 |
| α-helix | 741-755 | 15 | |
| α-helix | 762-797 | 36 | |
| α-helix | 799-802 | 4 | |
| β-strand | 805 | 1 | 37 |
| α-helix | 806-821 | 16 | |
| α-helix | 829-865 | 37 | |
| α-helix | 871-891 | 21 | |
| β-strand | 894 | 1 | 37 |
| α-helix | 896-926 | 31 | |
| β-strand | 960 | 1 | 38 |
| β-strand | 961-962 | 2 | 39 |
| β-strand | 971-972 | 2 | 39 |
| α-helix | 975-994 | 20 | |
| α-helix | 997-999 | 3 | |
| α-helix | 1014-1017 | 4 | |
| α-helix | 1020-1023 | 4 | |
| α-helix | 1031-1056 | 26 | |
| α-helix | 1058-1061 | 4 | |
| α-helix | 1065-1072 | 8 | |
| α-helix | 1076-1092 | 17 | |
| β-strand | 1106 | 1 | 38 |
| α-helix | 1110-1155 | 46 | |
| α-helix | 1163-1199 | 37 | |
| α-helix | 1211-1230 | 20 | |
| α-helix | 1236-1264 | 29 | |
| α-helix | 1273-1304 | 32 | |
| α-helix | 1314-1347 | 34 | |
| α-helix | 1356-1371 | 16 | |
| α-helix | 1375-1379 | 5 | |
| α-helix | 1381-1403 | 23 | |
8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Dynein light chain roadblock-type 1 | E, F | protein | 96 | Homo sapiens | Q9NP97 (AlphaFold model) |
| Isoform 2C of Cytoplasmic dynein 1 intermediate chain 2 | D, H, g, h | protein | 612 | Homo sapiens | Q13409 (AlphaFold model) |
| Dynein light chain 1, cytoplasmic | d, i | protein | 89 | Homo sapiens | P63167 (AlphaFold model) |
| Dynein light chain Tctex-type 1 | k, v | protein | 113 | Homo sapiens | P63172 (AlphaFold model) |
| Cytoplasmic dynein 1 light intermediate chain 2 | B, C | protein | 492 | Homo sapiens | O43237 |
| Cytoplasmic dynein 1 heavy chain 1 | A, G, e, f | protein | 4843 | Homo sapiens | Q14204 |
Sequence of entity 1 (E, F), FASTA
>9E23_1 Dynein light chain roadblock-type 1 (chains E, F)
MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDI
DPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE
Sequence of entity 2 (D, H, g, h), FASTA
>9E23_2 Isoform 2C of Cytoplasmic dynein 1 intermediate chain 2 (chains D, H, g, h)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRRGPIKLGMAKITQV
DFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPH
ELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLS
LNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPE
YVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYC
VNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNN
FVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTV
KLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASIS
VEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRA
DAEEEAATRIPA
Sequence of entity 3 (d, i), FASTA
>9E23_3 Dynein light chain 1, cytoplasmic (chains d, i)
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG
Sequence of entity 4 (k, v), FASTA
>9E23_4 Dynein light chain Tctex-type 1 (chains k, v)
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKP
FKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
Sequence of entity 5 (B, C), FASTA
>9E23_5 Cytoplasmic dynein 1 light intermediate chain 2 (chains B, C)
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVF
GEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK
FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKD
FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVL
EKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPA
LVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ
VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIK
NNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPD
SMVTNSSTENEA
Sequence of entity 6 (A, G, e, f), FASTA
>9E23_6 Cytoplasmic dynein 1 heavy chain 1 (chains A, G, e, f)
GDYDIPTTENLYFQGDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGKGTSAADAVEV
PAPAAVLGGPEPLMQATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVV
KFGEVISYSHLAALAGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVGGYEGGLAVKE
WLLAHEGHRLGKPGLGGSSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLE
DGGEAPAALEAALEEKSALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNI
NIDIHYGVKSNSLAFIKRTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKS
YIRESGKADRDGDKMAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYER
GEKPKVTDFGDKVEDPTFLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLER
ALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLND
LLSATELDKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMH
VAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARL
DQMRKFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEV
NLAYENVKEVDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFR
IFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPP
VSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWA
RKVQQRNLGVSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLA
IVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALV
WESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQK
AVDDLNLHSYSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAP
QVSHKPGGEPKIKNVVHELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQR
YQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDM
QAENIYNRLGEDLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSW
HKEVLSKFGQMLGSNMTEFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQF
EKQVELYRNGQRLLEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKI
VQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEA
LELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNL
DALLNQLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVN
WVVSELTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNK
CRLIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRR
WVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLER
LADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSS
IILNEDNSVVLGISSREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTE
VEIFGKATSIDPNTYITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLS
NVEVTLNVLADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMR
FYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGS
PFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRL
EERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYA
GRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQ
SHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCE
TMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMW
VEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDH
LYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNK
LLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLR
SIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQL
EHIMDLTRLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLS
GDSRLKMRAELGEYIRRITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVA
APDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFS
SATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFI
RQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPAS
LTQIYGTFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWV
RGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDR
EKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRID
RIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRS
GCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLM
LDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALY
QVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAK
RGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLR
IKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLD
KVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIM
RENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYA
DMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKA
DLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQ
MRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRF
NRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDP
VLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTV
TRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDD
DTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHF
LYQYSLQFFLDIYHNVLYENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITF
AMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPA
FKDLIAKVQADEQFGIWLDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLA
MAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQN
TQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFR
LFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLL
AWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSAL
KTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRRE
EFVQWVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKK
TRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKL
LQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFS
ERIKQLQNISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEV
NVTTSQGATLDACSFGVTGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKAS
VVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCTE
Primary citation
Cryo-EM captures early intermediate steps in dynein activation by LIS1. Nguyen, K.H.V., Karasmanis, E.P., Kendrick, A.A. et al. Nat Commun (2025) 16:7054-7054. DOI 10.1038/s41467-025-62185-z · PubMed
Other PDB entries of the same protein (UniProt Q9NP97 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2HZ5 2.1 Å, Crystal structure of human dynein light chain Dnlc2A
- 6F1Z 3.4 Å, Roadblock-1 region of the dynein tail/dynactin/BICDR1 complex
- 6F1T 3.5 Å, Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1
- 9BLY 3.5 Å, Composite structure of full-length human dynein-1 in phi-particle conformation
- 6SC2 3.9 Å, Structure of the dynein-2 complex; IFT-train bound model
- 8RGH 3.9 Å, Structure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2…
- 8RGG 4.0 Å, Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy…
- 8J07 4.1 Å, 96nm repeat of human respiratory doublet microtubule and associated axonemal complexes
- 9E28 4.4 Å, Cryo-EM structure of Phi dynein tail
- 6RLB 4.5 Å, Structure of the dynein-2 complex; tail domain
- 9E12 4.5 Å, Full-length human dynein-1 in phi comformation under Lis1 condition
- 9E13 4.5 Å, Full-length human dynein-1 in phi-like comformation bound to a Lis1 dimer under Lis1…
Browse structure collections
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