9HX9: SA2/SCC1/MCM3 complex

Structure of the SA2/SCC1/MCM3 complex. Determined by X-ray diffraction at 3.07 Å resolution. Released 22 Jul 2026.

Method
X-ray diffraction
Resolution
3.07 Å
Organism
Homo sapiens
Chains
3
Atoms
8,310
Mol. weight
131.13 kDa
Released
22 Jul 2026

Explore 9HX9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9HX9 contains 66 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 60 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix83-897
α-helix95-10814
α-helix110-12415
α-helix133-1386
α-helix141-15010
α-helix160-1623
α-helix166-18520
α-helix190-1923
α-helix196-20712
β-strand21211
α-helix213-25442
α-helix261-28828
α-helix289-2935
α-helix294-2963
β-strand29912
α-helix302-31817
α-helix320-3234
α-helix326-33510
α-helix341-35515
α-helix359-3613
α-helix365-37612
α-helix377-3804
β-strand38113
α-helix384-39916
α-helix407-4148
α-helix415-4184
β-strand41914
α-helix422-43615
α-helix458-47013
α-helix478-4847
α-helix489-4924
α-helix495-5039
α-helix515-53319
α-helix537-5382
α-helix550-57829
α-helix582-5887
α-helix591-5933
α-helix598-6025
α-helix606-62217
α-helix626-63914
α-helix647-67226
α-helix681-70020
α-helix704-7063
α-helix709-72214
α-helix727-74822
α-helix755-77521
α-helix781-79717
α-helix800-8034
α-helix808-8136
α-helix819-83214
α-helix850-87324
α-helix879-8824
α-helix883-8864
α-helix893-91018
α-helix912-93423
α-helix943-95715
α-helix967-98115
α-helix989-9913
α-helix997-9993
α-helix1000-10034
α-helix1004-10096
α-helix1012-102312
α-helix1030-10323
α-helix1039-10479
Chain B: 6 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand32611
β-strand33112
α-helix334-3429
α-helix345-3473
β-strand34813
β-strand35314
α-helix354-3552
α-helix358-3669
α-helix369-3746
α-helix383-3908

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cohesin subunit SA-2Aprotein981Homo sapiensQ8N3U4 (AlphaFold model)
64-kDa C-terminal productBprotein140Homo sapiensO60216 (AlphaFold model)
DNA replication licensing factor MCM3Cprotein12Homo sapiensP25205 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9HX9_1 Cohesin subunit SA-2 (chains A)
ENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHM
QNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDT
VISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKR
ANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMY
SDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMT
LDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSR
RDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMN
SLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDD
RTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNI
VEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEP
DEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCTHY
VILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFS
HQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDNNSADGQQEDEASKIEALH
KRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTL
ILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIE
FAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWL
PLMSYRNSLLAGGDDDTMSVI
Sequence of entity 2 (B), FASTA
>9HX9_2 64-kDa C-terminal product (chains B)
VDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQ
LSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPED
LRKRRKGGEADNLDEFLKEF
Sequence of entity 3 (C), FASTA
>9HX9_3 DNA replication licensing factor MCM3 (chains C)
SYDPYDFSDTEE

Primary citation

A shared principle by which CTCF and MCM3 control sister chromatid cohesion. Patel, A., Panne, D. To be published.

Other PDB entries of the same protein (UniProt Q8N3U4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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