9I68: Human Cdc20

Crystal structure of human Cdc20 bound to synthetic D-box peptide D21. Determined by X-ray diffraction at 1.5 Å resolution. Released 12 Feb 2025.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,734
Mol. weight: 55.81 kDa
Released: 12 Feb 2025

Explore 9I68 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9I68 contains 0 α-helices and 29 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	174-177	4	1
β-strand	188	1	2
β-strand	190-192	3	3
β-strand	197-202	6	3
β-strand	205-210	6	3
β-strand	216-221	6	3
β-strand	229-234	6	2
β-strand	240-245	6	2
β-strand	249-254	6	2
β-strand	259-265	7	2
β-strand	271-277	7	4
β-strand	280-285	6	4
β-strand	289-294	6	4
β-strand	301-306	6	4
β-strand	312-317	6	5
β-strand	323-328	6	5
β-strand	333-337	5	5
β-strand	349-351	3	5
β-strand	358-363	6	6
β-strand	370-375	6	6
β-strand	381-386	6	6
β-strand	392-397	6	6
β-strand	402-408	7	7
β-strand	413-418	6	7
β-strand	425-429	5	7
β-strand	434-439	6	7
β-strand	446-451	6	1
β-strand	458-462	5	1
β-strand	466-470	5	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cell division cycle protein 20 homolog	A	protein	499	Homo sapiens	Q12834 (AlphaFold model)
Arg-ala-pro-3EG-ser-asp	B	protein	9	Homo sapiens

Sequence of entity 1 (A), FASTA

>9I68_1 Cell division cycle protein 20 homolog (chains A)
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP
GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL
NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE
IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY
LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH
HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA
VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF
AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR
REREKASAAKSSLIHQGIR

Sequence of entity 2 (B), FASTA

>9I68_2 ARG-ALA-PRO-3EG-SER-ASP (chains B)
RAPXSDITN

Primary citation

Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome. Eapen, R., Okoye, C., Stubbs, C. et al. Elife (2025) 14. DOI 10.7554/eLife.104238 · PubMed

Other PDB entries of the same protein (UniProt Q12834 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4GGC 1.35 Å, Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C
9I69 1.46 Å, Crystal structure of human Cdc20 bound to synthetic D-box peptide D20
9I6A 1.92 Å, Crystal structure of human Cdc20 bound to synthetic D-box peptide D7
4GGA 2.04 Å, Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C
4N14 2.1 Å, Crystal structure of Cdc20 and apcin complex
4GGD 2.44 Å, Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
9N9R 3.9 Å, Model of APC/C-CDC20-UBE2C from H2A/H2B-bound complex
9N9S 3.9 Å, Model of APC/C-CDC20-UBE2C from H3/H4-bound complex

Browse structure collections

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