6Q6H: Anaphase-promoting complex subunit 10
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class. Determined by electron microscopy at 3.2 Å resolution. Released 11 Sept 2019.
- Method
- Electron microscopy
- Resolution
- 3.2 Å
- Organism
- Homo sapiens
- Chains
- 21
- Atoms
- 67,944
- Mol. weight
- 1262.16 kDa
- Released
- 11 Sept 2019
Explore 6Q6H in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6Q6H contains 454 α-helices and 154 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 75 helices, 58 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-13 | 2 | 6 |
| β-strand | 18-19 | 2 | 7 |
| α-helix | 25-28 | 4 | |
| α-helix | 41-46 | 6 | |
| β-strand | 73 | 1 | 8 |
| β-strand | 76-78 | 3 | 8 |
| β-strand | 90-96 | 7 | 8 |
| β-strand | 99-103 | 5 | 8 |
| β-strand | 113-118 | 6 | 8 |
| β-strand | 125-132 | 8 | 9 |
| α-helix | 144-146 | 3 | |
| β-strand | 147-154 | 8 | 9 |
| β-strand | 158-163 | 6 | 9 |
| β-strand | 168-172 | 5 | 9 |
| β-strand | 177-182 | 6 | 10 |
| β-strand | 187-191 | 5 | 10 |
| α-helix | 206-208 | 3 | |
| β-strand | 210-213 | 4 | 10 |
| β-strand | 221-222 | 2 | 10 |
| β-strand | 224-226 | 3 | 11 |
| β-strand | 237-238 | 2 | 11 |
| β-strand | 244-249 | 6 | 11 |
| β-strand | 255-260 | 6 | 11 |
| β-strand | 265-273 | 9 | 11 |
| α-helix | 401-403 | 3 | |
| β-strand | 407-414 | 8 | 11 |
| β-strand | 430-434 | 5 | 12 |
| β-strand | 440-446 | 7 | 12 |
| β-strand | 451-459 | 9 | 12 |
| β-strand | 466-468 | 3 | 12 |
| β-strand | 473-474 | 2 | 12 |
| β-strand | 478-482 | 5 | 13 |
| β-strand | 487-491 | 5 | 13 |
| β-strand | 497-500 | 4 | 13 |
| β-strand | 505-508 | 4 | 13 |
| β-strand | 509-510 | 2 | 6 |
| β-strand | 584-591 | 8 | 7 |
| β-strand | 594-599 | 6 | 7 |
| β-strand | 604-608 | 5 | 7 |
| α-helix | 617-628 | 12 | |
| α-helix | 631-645 | 15 | |
| α-helix | 656-667 | 12 | |
| α-helix | 704-711 | 8 | |
| α-helix | 714-721 | 8 | |
| β-strand | 747 | 1 | 14 |
| α-helix | 756-758 | 3 | |
| α-helix | 759-773 | 15 | |
| α-helix | 777-779 | 3 | |
| α-helix | 783-794 | 12 | |
| α-helix | 800-807 | 8 | |
| α-helix | 820 | 1 | |
| β-strand | 821 | 1 | 14 |
| α-helix | 822 | 1 | |
| α-helix | 844-849 | 6 | |
| α-helix | 858-859 | 2 | |
| β-strand | 860-862 | 3 | 15 |
| α-helix | 868-877 | 10 | |
| α-helix | 878-882 | 5 | |
| β-strand | 896-898 | 3 | 15 |
| α-helix | 927-937 | 11 | |
| α-helix | 941-944 | 4 | |
| α-helix | 949-963 | 15 | |
| α-helix | 975-978 | 4 | |
| α-helix | 981-983 | 3 | |
| α-helix | 1011-1013 | 3 | |
| α-helix | 1021-1027 | 7 | |
| α-helix | 1033-1040 | 8 | |
| α-helix | 1046 | 1 | |
| β-strand | 1047-1048 | 2 | 16 |
| α-helix | 1052-1054 | 3 | |
| α-helix | 1059-1077 | 19 | |
| α-helix | 1080-1087 | 8 | |
| β-strand | 1092 | 1 | 17 |
| α-helix | 1099-1100 | 2 | |
| α-helix | 1102-1104 | 3 | |
| β-strand | 1109-1111 | 3 | 16 |
| β-strand | 1116-1118 | 3 | 16 |
| α-helix | 1133-1144 | 12 | |
| β-strand | 1147 | 1 | 17 |
| α-helix | 1155-1159 | 5 | |
| α-helix | 1169-1181 | 13 | |
| α-helix | 1185-1187 | 3 | |
| α-helix | 1190-1197 | 8 | |
| α-helix | 1202-1214 | 13 | |
| α-helix | 1222-1229 | 8 | |
| α-helix | 1247-1260 | 14 | |
| α-helix | 1267-1277 | 11 | |
| α-helix | 1291-1306 | 16 | |
| α-helix | 1321-1330 | 10 | |
| β-strand | 1352-1353 | 2 | 2 |
| α-helix | 1360-1374 | 15 | |
| α-helix | 1393-1396 | 4 | |
| α-helix | 1401-1414 | 14 | |
| α-helix | 1423-1427 | 5 | |
| α-helix | 1432-1436 | 5 | |
| α-helix | 1455-1475 | 21 | |
| β-strand | 1481 | 1 | 18 |
| α-helix | 1482-1499 | 18 | |
| α-helix | 1504-1507 | 4 | |
| α-helix | 1509-1526 | 18 | |
| α-helix | 1533-1543 | 11 | |
| α-helix | 1552-1565 | 14 | |
| α-helix | 1567-1570 | 4 | |
| β-strand | 1572-1574 | 3 | 19 |
| α-helix | 1578-1587 | 10 | |
| α-helix | 1604-1612 | 9 | |
| β-strand | 1614-1616 | 3 | 19 |
| β-strand | 1618-1619 | 2 | 20 |
| β-strand | 1620-1623 | 4 | 21 |
| β-strand | 1628-1629 | 2 | 21 |
| β-strand | 1633-1638 | 6 | 22 |
| α-helix | 1639-1640 | 2 | |
| β-strand | 1647-1652 | 6 | 22 |
| β-strand | 1655-1656 | 2 | 20 |
| β-strand | 1663-1669 | 7 | 22 |
| β-strand | 1673 | 1 | 23 |
| β-strand | 1676-1679 | 4 | 22 |
| α-helix | 1684-1692 | 9 | |
| β-strand | 1696-1699 | 4 | 21 |
| β-strand | 1701 | 1 | 23 |
| α-helix | 1727-1731 | 5 | |
| α-helix | 1737-1740 | 4 | |
| α-helix | 1745-1753 | 9 | |
| α-helix | 1765-1780 | 16 | |
| α-helix | 1787-1799 | 13 | |
| α-helix | 1809-1818 | 10 | |
| α-helix | 1824-1828 | 5 | |
| α-helix | 1845-1862 | 18 | |
| α-helix | 1865-1873 | 9 | |
| α-helix | 1875-1878 | 4 | |
| α-helix | 1882-1891 | 10 | |
| α-helix | 1912-1919 | 8 | |
| α-helix | 1925-1931 | 7 | |
Chain C: 3 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-4 | 2 | 27 |
| β-strand | 7-8 | 2 | 24 |
| β-strand | 11 | 1 | 25 |
| β-strand | 13-14 | 2 | 26 |
| α-helix | 33-34 | 2 | |
| α-helix | 35-37 | 3 | |
| β-strand | 47 | 1 | 38 |
| β-strand | 55 | 1 | 38 |
| α-helix | 58-65 | 8 | |
Chain D: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| α-helix | 26-45 | 20 | |
Chain G: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-7 | 4 | |
| α-helix | 13-15 | 3 | |
| α-helix | 16-26 | 11 | |
Chain H: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 52-91 | 40 | |
| α-helix | 93-95 | 3 | |
| α-helix | 99-102 | 4 | |
Chain I: 23 helices, 35 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-15 | 4 | 28 |
| β-strand | 18 | 1 | 29 |
| β-strand | 23-28 | 6 | 30 |
| β-strand | 35-39 | 5 | 30 |
| β-strand | 44-47 | 4 | 30 |
| β-strand | 54-58 | 5 | 30 |
| β-strand | 68-73 | 6 | 31 |
| β-strand | 79-84 | 6 | 31 |
| β-strand | 89-94 | 6 | 31 |
| β-strand | 102-105 | 4 | 31 |
| β-strand | 110-117 | 8 | 32 |
| α-helix | 120-123 | 4 | |
| β-strand | 153 | 1 | 31 |
| α-helix | 163-169 | 7 | |
| α-helix | 172-173 | 2 | |
| β-strand | 174-180 | 7 | 32 |
| β-strand | 185-189 | 5 | 32 |
| β-strand | 193-198 | 6 | 32 |
| β-strand | 204-210 | 7 | 33 |
| β-strand | 216-223 | 8 | 33 |
| β-strand | 229-237 | 9 | 33 |
| α-helix | 240-243 | 4 | |
| α-helix | 245-274 | 30 | |
| α-helix | 282-292 | 11 | |
| α-helix | 300-310 | 11 | |
| α-helix | 315-319 | 5 | |
| α-helix | 320-324 | 5 | |
| α-helix | 329-347 | 19 | |
| α-helix | 348-352 | 5 | |
| α-helix | 353-371 | 19 | |
| α-helix | 383-426 | 44 | |
| α-helix | 442-455 | 14 | |
| α-helix | 476-479 | 4 | |
| β-strand | 485 | 1 | 34 |
| α-helix | 496-502 | 7 | |
| α-helix | 514-516 | 3 | |
| β-strand | 520 | 1 | 34 |
| α-helix | 522-545 | 24 | |
| β-strand | 554-559 | 6 | 33 |
| α-helix | 561-563 | 3 | |
| β-strand | 574-578 | 5 | 35 |
| β-strand | 583-592 | 10 | 35 |
| β-strand | 595-604 | 10 | 35 |
| β-strand | 615-623 | 9 | 35 |
| β-strand | 632-633 | 2 | 35 |
| β-strand | 636-645 | 10 | 36 |
| β-strand | 648-655 | 8 | 36 |
| β-strand | 664-670 | 7 | 36 |
| α-helix | 671-674 | 4 | |
| α-helix | 677-680 | 4 | |
| β-strand | 702-707 | 6 | 35 |
| β-strand | 711-713 | 3 | 36 |
| β-strand | 719-725 | 7 | 28 |
| β-strand | 730-735 | 6 | 28 |
| β-strand | 740 | 1 | 29 |
| β-strand | 741-745 | 5 | 28 |
| α-helix | 749-750 | 2 | |
| α-helix | 753-754 | 2 | |
Chain J: 34 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-34 | 14 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-62 | 9 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-92 | 8 | |
| β-strand | 94 | 1 | 39 |
| α-helix | 99 | 1 | |
| β-strand | 100 | 1 | 39 |
| α-helix | 101-102 | 2 | |
| α-helix | 103-110 | 8 | |
| α-helix | 111-113 | 3 | |
| α-helix | 114-127 | 14 | |
| α-helix | 131-144 | 14 | |
| α-helix | 149-157 | 9 | |
| α-helix | 164-167 | 4 | |
| α-helix | 452-477 | 26 | |
| α-helix | 481-489 | 9 | |
| α-helix | 493-496 | 4 | |
| α-helix | 499-511 | 13 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-546 | 11 | |
| α-helix | 549-562 | 14 | |
| α-helix | 567-579 | 13 | |
| α-helix | 583-596 | 14 | |
| α-helix | 601-613 | 13 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-647 | 13 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-681 | 13 | |
| α-helix | 685-698 | 14 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-730 | 12 | |
| α-helix | 737-749 | 13 | |
| α-helix | 753-765 | 13 | |
| α-helix | 772-779 | 8 | |
Chain K: 31 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-15 | 13 | |
| α-helix | 19-32 | 14 | |
| α-helix | 37-49 | 13 | |
| α-helix | 53-61 | 9 | |
| α-helix | 70-82 | 13 | |
| α-helix | 86-93 | 8 | |
| α-helix | 129-142 | 14 | |
| α-helix | 146-159 | 14 | |
| α-helix | 164-170 | 7 | |
| α-helix | 178-187 | 10 | |
| α-helix | 195-209 | 15 | |
| α-helix | 226-229 | 4 | |
| α-helix | 234-243 | 10 | |
| α-helix | 247-260 | 14 | |
| α-helix | 267-275 | 9 | |
| α-helix | 281-294 | 14 | |
| α-helix | 299-312 | 14 | |
| α-helix | 316-329 | 14 | |
| α-helix | 334-345 | 12 | |
| α-helix | 350-363 | 14 | |
| α-helix | 369-379 | 11 | |
| α-helix | 384-397 | 14 | |
| α-helix | 402-413 | 12 | |
| α-helix | 418-435 | 18 | |
| α-helix | 445-457 | 13 | |
| α-helix | 461-474 | 14 | |
| α-helix | 479-491 | 13 | |
| α-helix | 495-508 | 14 | |
| α-helix | 513-527 | 15 | |
| β-strand | 551 | 1 | 18 |
| α-helix | 555-559 | 5 | |
| α-helix | 561-563 | 3 | |
12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 10 | L | protein | 185 | Homo sapiens | Q9UM13 (AlphaFold model) |
| Anaphase-promoting complex subunit 15 | D | protein | 121 | Homo sapiens | P60006 (AlphaFold model) |
| Apc1 | A | protein | 1855 | Homo sapiens | Q9H1A4 (AlphaFold model) |
| Anaphase-promoting complex subunit 2 | N | protein | 822 | Homo sapiens | Q9UJX6 (AlphaFold model) |
| Anaphase-promoting complex subunit 4 | I | protein | 808 | Homo sapiens | Q9UJX5 |
| Anaphase-promoting complex subunit 5 | O | protein | 755 | Homo sapiens | Q9UJX4 |
| Cell division cycle protein 16 homolog | K, Q | protein | 620 | Homo sapiens | Q13042 |
| Anaphase-promoting complex subunit 11 | C | protein | 84 | Homo sapiens | Q9NYG5 |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | Homo sapiens | Q8NHZ8 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | Homo sapiens | Q9BS18 |
| Anaphase-promoting complex subunit 16 | H | protein | 110 | Homo sapiens | Q96DE5 |
| Cell division cycle protein 27 homolog | J, P | protein | 824 | Homo sapiens | P30260 |
4 more molecules are not listed.
Sequence of entity 1 (L), FASTA
>6Q6H_1 Anaphase-promoting complex subunit 10 (chains L)
MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 2 (D), FASTA
>6Q6H_2 Anaphase-promoting complex subunit 15 (chains D)
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASE
HYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWM
I
Sequence of entity 3 (A), FASTA
>6Q6H_3 Apc1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGTPQNVATSSS
LTAHLRLAPETEPIVPELCIDHLWTETITNIRESNSQASKVFITSDLCGQKFLCFLVESQ
LQLRCVKFQESNDKTQLIFGSVTNIPAKDAAPVEKIDTMLVLEGSGNLVLYTGVVRVGKV
FIPGLPAPSLTMSNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDS
LYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPEIATSELVQTCLQAIKFIL
PKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSP
VIAPKKARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSL
DSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRD
YPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICER
SRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAER
LVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSKQACE
GNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRV
NVVQYPELSDHEFIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTG
RAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPASQIDSAWIVYNKPKHAELA
NEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLS
IHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCT
DRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRRFQTGMHREKHKSPS
YQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTL
ARCLILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGAC
LSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHNLETCLSVVLLSLAMVMAG
SGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALY
PHFPAHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKE
ELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSILSKDGVLYVKLRAGQLSYK
EDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILD
LFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQER
LQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAYLSGQPLEESQLSMLACFL
VYHSVPAPQHLPPIGLEGSTSFAELLFKFKQLKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 4 (N), FASTA
>6Q6H_4 Anaphase-promoting complex subunit 2 (chains N)
MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF
HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW
VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIR
NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
VVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS
Sequence of entity 5 (I), FASTA
>6Q6H_5 Anaphase-promoting complex subunit 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESE
AENQQAGAAALAPEIVIKVEKLDPELDS
Sequence of entity 6 (O), FASTA
>6Q6H_6 Anaphase-promoting complex subunit 5 (chains O)
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRL
NQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFS
GTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR
DEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKEL
NNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSL
RYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVL
LEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDI
SIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQ
GCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNS
IEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIA
LPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDK
GRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARL
YHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL
Sequence of entity 7 (K, Q), FASTA
>6Q6H_7 Cell division cycle protein 16 homolog (chains K, Q)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 8 (C), FASTA
>6Q6H_8 Anaphase-promoting complex subunit 11 (chains C)
MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLHAQQVQQHCPMCRQEWKFKE
Sequence of entity 9 (G, W), FASTA
>6Q6H_9 Anaphase-promoting complex subunit CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQM
INDRIGYKPQPKPNNRSSQFGSLEF
Sequence of entity 10 (M), FASTA
>6Q6H_10 Anaphase-promoting complex subunit 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Sequence of entity 11 (H), FASTA
>6Q6H_11 Anaphase-promoting complex subunit 16 (chains H)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 12 (J, P), FASTA
>6Q6H_12 Cell division cycle protein 27 homolog (chains J, P)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Primary citation
Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. Zhang, S., Tischer, T., Barford, D. Nat Commun (2019) 10:3863-3863. DOI 10.1038/s41467-019-11833-2 · PubMed
Other PDB entries of the same protein (UniProt Q9UM13 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1JHJ 1.6 Å, Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex
- 9GAW 2.9 Å, High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to…
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 8PKP 3.2 Å, Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2…
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 8TAU 3.5 Å, APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
- 9N9R 3.9 Å, Model of APC/C-CDC20-UBE2C from H2A/H2B-bound complex
Browse structure collections
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