9J0O: DNA-directed RNA polymerase subunit

Arrested elongation complex of mammalian RNA polymerase II with nucleosome (AEC1-nuc). Determined by electron microscopy at 3.3 Å resolution. Released 5 Feb 2025.

Method
Electron microscopy
Resolution
3.3 Å
Organisms
Sus scrofa, Homo sapiens
Chains
29
Atoms
59,777
Mol. weight
1128.68 kDa
Ligands
ZN, MG
Released
5 Feb 2025

Explore 9J0O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9J0O contains 330 α-helices and 291 β-strands across 26 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 4 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix46-5611
α-helix64-7613
β-strand83-84286
α-helix86-11328
β-strand118-119287
α-helix121-13111
Chain A: 80 helices, 69 β-strands
ElementResiduesLengthSheet
β-strand1511
β-strand20-2232
α-helix25-273
α-helix28-347
β-strand4313
β-strand47-4934
β-strand51-5224
α-helix531
β-strand5613
β-strand86-9495
α-helix100-10910
β-strand11016
β-strand11716
α-helix124-1329
α-helix137-14812
α-helix1891
β-strand190-19457
β-strand197-20157
β-strand214-21527
α-helix218-22710
α-helix230-2356
α-helix245-2484
β-strand250-25565
α-helix2561
β-strand26418
β-strand27218
α-helix273-2742
α-helix275-29218
α-helix293-2975
α-helix302-31817
α-helix326-3283
β-strand32919
α-helix3341
β-strand33519
α-helix3361
α-helix339-3424
α-helix3491
α-helix350-3545
β-strand357-359310
β-strand362-369811
β-strand377-381511
α-helix382-3876
β-strand389-393512
α-helix396-3983
α-helix399-40810
β-strand416-420512
β-strand426-428312
α-helix435-4384
β-strand445-449512
α-helix4501
β-strand455-459511
α-helix466-4683
β-strand469-477911
β-strand482-484311
α-helix486-4894
β-strand500-504511
α-helix509-51810
β-strand520111
α-helix521-5244
β-strand526113
β-strand533113
α-helix539-54810
β-strand554-555214
α-helix557-5648
α-helix5741
β-strand575115
α-helix576-5772
β-strand579-581316
β-strand585116
β-strand586-587214
α-helix588-5958
β-strand602-603217
α-helix612-6143
β-strand629-631317
β-strand634-637417
α-helix642-6454
α-helix652-6598
α-helix663-68321
β-strand686118
α-helix689-6924
α-helix698-72124
α-helix725-7284
α-helix733-75927
α-helix765-7717
α-helix778-7858
β-strand789-790219
β-strand793120
β-strand796120
β-strand822-823219
α-helix833-86735
β-strand872-873221
β-strand879-880221
β-strand886-888321
α-helix891-8933
β-strand896122
β-strand902-905423
α-helix913-9208
α-helix927-9337
β-strand934124
α-helix936-9449
α-helix946-96924
α-helix971-9733
β-strand976-979423
α-helix983-99311
β-strand1002124
α-helix1006-101914
α-helix1028-103710
α-helix1039-104810
α-helix1051-10566
α-helix1062-107716
β-strand1080122
α-helix1081-10822
α-helix1087-109913
α-helix1121-11288
β-strand1140-1142325
β-strand1143126
α-helix1146-11483
α-helix1152-116110
β-strand1164127
α-helix1166-11694
β-strand1170-1176728
α-helix1190-11945
β-strand1211-1216628
α-helix1218-12236
α-helix1228-123912
α-helix1240-12423
β-strand1243-1247528
α-helix1248-12492
β-strand1256-1261628
α-helix1283-129311
β-strand1299127
β-strand1307-1310425
β-strand1319-1320229
β-strand1330-1331229
β-strand1335-1338425
α-helix1345-13484
β-strand1352126
β-strand1358125
α-helix1362-13687
α-helix1371-138616
α-helix1387-13893
α-helix1395-140511
α-helix1416-14194
α-helix1426-14327
α-helix1435-144511
β-strand1448-144922
α-helix1454-14596
β-strand1471-1475530
α-helix1477-14804
Chain b: 3 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix31-4010
β-strand45-46287
α-helix50-7526
β-strand80-81286
α-helix83-9311
β-strand96-97288
Chain B: 53 helices, 73 β-strands
ElementResiduesLengthSheet
α-helix22-3615
α-helix41-499
α-helix50-545
α-helix55-617
α-helix63-642
β-strand83132
β-strand87-93733
β-strand97-98234
β-strand106-107234
α-helix108-1092
α-helix110-1167
β-strand121-1321233
β-strand133132
β-strand140-1531433
α-helix168-1725
β-strand185-187335
β-strand190-194535
α-helix1951
β-strand196-200536
α-helix2011
β-strand206-208337
β-strand215-223937
α-helix231-2322
β-strand233-240837
β-strand256-259437
β-strand263138
β-strand267-268237
α-helix269-2768
α-helix281-2888
α-helix297-30711
α-helix314-3229
β-strand325138
α-helix332-34514
α-helix358-37720
α-helix381-3833
β-strand391-394436
α-helix396-42126
α-helix427-4304
α-helix431-4344
α-helix438-45013
α-helix459-4613
β-strand467-469335
α-helix475-4817
β-strand484-486336
β-strand509139
β-strand523-525336
β-strand526139
β-strand531-532240
α-helix539-5479
β-strand551141
α-helix553-5553
α-helix558-5603
β-strand565-569541
β-strand572-577641
α-helix580-59314
β-strand602-606541
β-strand611-615541
β-strand621-627740
β-strand628142
β-strand633142
α-helix637-6448
α-helix653-6586
β-strand662-666540
α-helix669-6713
β-strand675-676240
α-helix679-6835
β-strand695-696240
α-helix700-7034
α-helix707-7104
α-helix714-7163
α-helix719-72810
β-strand732143
β-strand748-751444
β-strand755145
β-strand759-760246
α-helix762-7676
β-strand776-782747
β-strand783118
β-strand793-797547
α-helix798-8025
β-strand808-8171044
β-strand827-829348
β-strand837-839348
β-strand853149
β-strand859144
β-strand865-867349
β-strand869-872448
β-strand889-891348
β-strand894-895249
α-helix896-8972
β-strand903-911944
β-strand917-9271144
β-strand934-936347
β-strand943-949747
β-strand956150
β-strand965-967347
α-helix969-9713
α-helix978-99316
β-strand997-998246
α-helix1008-10158
α-helix1016-10183
β-strand1025-1026247
α-helix10281
β-strand1029150
α-helix10301
α-helix10351
β-strand1036150
α-helix10371
β-strand1041-10501047
β-strand1051143
α-helix1055-10573
β-strand1060-1062311
β-strand1067151
β-strand1074151
β-strand1084-1086310
α-helix1088-109710
α-helix1100-11045
α-helix1105-11095
β-strand1115-111951
β-strand112511
α-helix11261
β-strand1127152
β-strand1136152
β-strand1146-115051
α-helix1153-116412
β-strand1170-117232
Chain c: 4 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix27-3711
β-strand42-43289
α-helix46-7227
α-helix80-8910
α-helix92-965
β-strand101-102290
Chain C: 9 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand8-14753
β-strand18-24753
α-helix28-3912
β-strand44-551254
α-helix61-699
β-strand73155
β-strand99-106854
α-helix1121
β-strand113-116456
α-helix117-1193
β-strand121-122254
β-strand129155
β-strand149-153556
β-strand158-1681154
α-helix174-1763
β-strand179-182453
β-strand185153
α-helix200-2023
α-helix204-2063
α-helix218-2203
β-strand229-235753
α-helix241-26929
Chain d: 4 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix37-459
α-helix53-8028
β-strand85-86289
α-helix88-9811
α-helix101-12020
Chain D: 10 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix24-274
α-helix291
β-strand30-31230
α-helix34-4916
α-helix55-584
α-helix59-6911
α-helix77-8913
α-helix94-10310
α-helix108-1147
α-helix116-1183
α-helix124-13714

18 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA-directed RNA polymerase subunitAprotein1970Sus scrofaA0A8D1DPV6
DNA-directed RNA polymerase subunit betaBprotein1174Sus scrofaA0A0B8RVL1 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3Cprotein271Sus scrofaI3LCH3 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4Dprotein142Sus scrofaA0A4X1VM56 (AlphaFold model)
DNA-directed RNA polymerase II subunit EEprotein210Sus scrofaI3LSI7
DNA-directed RNA polymerase II subunit FFprotein127Sus scrofaA0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7Gprotein172Sus scrofaA0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3Hprotein150Sus scrofaI3LCB2
DNA-directed RNA polymerase II subunit RPB9Iprotein125Sus scrofaP60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5Jprotein67Sus scrofaA0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-aKprotein117Sus scrofaF1RKE4
RPB12Lprotein58Sus scrofaA0A4X1TRS6

13 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>9J0O_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN
Sequence of entity 2 (B), FASTA
>9J0O_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Sequence of entity 3 (C), FASTA
>9J0O_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDV
Sequence of entity 4 (D), FASTA
>9J0O_4 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY
Sequence of entity 5 (E), FASTA
>9J0O_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Sequence of entity 6 (F), FASTA
>9J0O_6 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD
Sequence of entity 7 (G), FASTA
>9J0O_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
Sequence of entity 8 (H), FASTA
>9J0O_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF
Sequence of entity 9 (I), FASTA
>9J0O_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE
Sequence of entity 10 (J), FASTA
>9J0O_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK
Sequence of entity 11 (K), FASTA
>9J0O_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE
Sequence of entity 12 (L), FASTA
>9J0O_12 RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn9
MGMagnesium ionMg1

Primary citation

Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome. Naganuma, M., Kujirai, T., Ehara, H. et al. Sci Adv (2025) 11:eadu0577-eadu0577. DOI 10.1126/sciadv.adu0577 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

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