Cryo-EM structure of human TRPV3 in complex with citral determined in MSP2N2 nanodisc. Determined by electron microscopy at 3.51 Å resolution. Released 26 Mar 2025.
Explore 9JEE in 3D Show helices and sheets RCSB PDB PDBe
9JEE contains 144 α-helices and 36 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 121-129 | 9 | |
| α-helix | 132-145 | 14 | |
| α-helix | 160-162 | 3 | |
| α-helix | 171-177 | 7 | |
| α-helix | 184-196 | 13 | |
| β-strand | 210 | 1 | 1 |
| β-strand | 213 | 1 | 1 |
| α-helix | 219-222 | 4 | |
| α-helix | 229-236 | 8 | |
| α-helix | 267-271 | 5 | |
| α-helix | 275-282 | 8 | |
| α-helix | 299-305 | 7 | |
| α-helix | 316-328 | 13 | |
| α-helix | 336-338 | 3 | |
| α-helix | 344-350 | 7 | |
| α-helix | 354-361 | 8 | |
| α-helix | 371-373 | 3 | |
| β-strand | 377-382 | 6 | 2 |
| β-strand | 385-390 | 6 | 2 |
| α-helix | 403-408 | 6 | |
| α-helix | 416-419 | 4 | |
| α-helix | 423-432 | 10 | |
| α-helix | 433-437 | 5 | |
| α-helix | 438-456 | 19 | |
| α-helix | 486-489 | 4 | |
| α-helix | 491-504 | 14 | |
| α-helix | 511-514 | 4 | |
| α-helix | 521-541 | 21 | |
| α-helix | 552-558 | 7 | |
| α-helix | 564-568 | 5 | |
| α-helix | 570-575 | 6 | |
| α-helix | 578-582 | 5 | |
| α-helix | 583-587 | 5 | |
| α-helix | 588-598 | 11 | |
| α-helix | 602-608 | 7 | |
| β-strand | 609 | 1 | 3 |
| α-helix | 610-612 | 3 | |
| α-helix | 625-636 | 12 | |
| β-strand | 648 | 1 | 3 |
| α-helix | 651-680 | 30 | |
| α-helix | 689-705 | 17 | |
| α-helix | 709-711 | 3 | |
| β-strand | 717 | 1 | 4 |
| β-strand | 731 | 1 | 4 |
| β-strand | 732-737 | 6 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 3 | A, B, C, D | protein | 799 | Homo sapiens | Q8NET8 (AlphaFold model) |
>9JEE_1 Transient receptor potential cation channel subfamily V member 3 (chains A, B, C, D) MKAHPKEMVPLMGKRVAAPSGNPAVLPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE EVEEFPETSVSNSLEVLFQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| GRQ | Geranaldehyde | C10 H16 O | 4 |
| POV | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl… | C42 H82 N O8 P | 20 |
Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action. Li, Y., Lu, X., Cheng, X. et al. Nat Commun (2025) 16:2728-2728. DOI 10.1038/s41467-025-58033-9 · PubMed
Other PDB entries of the same protein (UniProt Q8NET8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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