Cryo-EM structure of human TRPV3 in complex with isodihydrolavandulal determined in MSP2N2 nanodisc. Determined by electron microscopy at 3.39 Å resolution. Released 26 Mar 2025.
Explore 9JEG in 3D Show helices and sheets RCSB PDB PDBe
9JEG contains 152 α-helices and 44 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 121-129 | 9 | |
| α-helix | 133-142 | 10 | |
| α-helix | 145-148 | 4 | |
| β-strand | 163 | 1 | 1 |
| β-strand | 170 | 1 | 1 |
| α-helix | 171-177 | 7 | |
| α-helix | 184-197 | 14 | |
| α-helix | 200-204 | 5 | |
| β-strand | 209 | 1 | 2 |
| β-strand | 214 | 1 | 2 |
| α-helix | 218-224 | 7 | |
| α-helix | 228-236 | 9 | |
| α-helix | 265-271 | 7 | |
| α-helix | 275-283 | 9 | |
| α-helix | 299-306 | 8 | |
| α-helix | 317-328 | 12 | |
| α-helix | 344-350 | 7 | |
| α-helix | 354-361 | 8 | |
| α-helix | 371-373 | 3 | |
| β-strand | 376-382 | 7 | 3 |
| β-strand | 385-391 | 7 | 3 |
| α-helix | 403-408 | 6 | |
| α-helix | 417-420 | 4 | |
| α-helix | 423-432 | 10 | |
| α-helix | 433-437 | 5 | |
| α-helix | 438-460 | 23 | |
| α-helix | 484-507 | 24 | |
| α-helix | 510-513 | 4 | |
| α-helix | 521-541 | 21 | |
| α-helix | 547-560 | 14 | |
| α-helix | 561-566 | 6 | |
| α-helix | 570-582 | 13 | |
| α-helix | 583-587 | 5 | |
| α-helix | 588-598 | 11 | |
| α-helix | 602-607 | 6 | |
| β-strand | 609 | 1 | 4 |
| α-helix | 610-612 | 3 | |
| α-helix | 613-615 | 3 | |
| α-helix | 625-637 | 13 | |
| β-strand | 648 | 1 | 4 |
| α-helix | 651-656 | 6 | |
| α-helix | 662-665 | 4 | |
| α-helix | 670-683 | 14 | |
| α-helix | 688-704 | 17 | |
| α-helix | 711-713 | 3 | |
| β-strand | 719 | 1 | 5 |
| β-strand | 730 | 1 | 5 |
| β-strand | 731-737 | 7 | 3 |
| α-helix | 739-746 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 3 | A, B, C, D | protein | 799 | Homo sapiens | Q8NET8 (AlphaFold model) |
>9JEG_1 Transient receptor potential cation channel subfamily V member 3 (chains A, B, C, D) MKAHPKEMVPLMGKRVAAPSGNPAVLPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE EVEEFPETSVSNSLEVLFQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| A1EBM | (~{Z})-5-methyl-2-propan-2-yl-hex-2-enal | C10 H18 O | 8 |
| POV | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl… | C42 H82 N O8 P | 16 |
Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action. Li, Y., Lu, X., Cheng, X. et al. Nat Commun (2025) 16:2728-2728. DOI 10.1038/s41467-025-58033-9 · PubMed
Other PDB entries of the same protein (UniProt Q8NET8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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