9LHZ: Sodium channel protein PaFPC1

Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and sea anemone toxin Av3. Determined by electron microscopy at 2.79 Å resolution. Released 4 Feb 2026.

Method
Electron microscopy
Resolution
2.79 Å
Organisms
Periplaneta americana, Anemonia sulcata
Chains
2
Atoms
10,753
Mol. weight
189.33 kDa
Ligands
LPE, NAG
Released
4 Feb 2026

Explore 9LHZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9LHZ contains 89 α-helices and 11 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 89 helices, 9 β-strands

ElementResiduesLengthSheet
α-helix48-525
α-helix53-564
α-helix97-993
α-helix103-1075
α-helix130-1389
α-helix140-15819
α-helix166-18722
α-helix200-21516
α-helix226-2294
α-helix231-2388
α-helix244-25714
α-helix259-27921
α-helix283-2853
β-strand287-29041
α-helix291-2922
α-helix305-3106
α-helix313-3153
β-strand31611
α-helix325-3273
α-helix337-3382
β-strand341-34441
α-helix351-3544
α-helix361-37313
α-helix377-38711
α-helix390-3923
α-helix393-40210
α-helix403-4075
α-helix408-42417
α-helix425-4306
α-helix431-4344
α-helix503-5064
α-helix508-5169
α-helix521-53616
α-helix545-57127
α-helix575-5784
α-helix582-59918
α-helix609-62214
α-helix625-63612
α-helix639-66931
α-helix671-6733
α-helix675-6773
α-helix687-69913
α-helix703-71210
α-helix717-7259
α-helix726-7338
α-helix734-7429
α-helix835-8384
α-helix841-8422
α-helix843-8486
α-helix849-8535
α-helix856-87217
α-helix873-8753
α-helix880-8823
α-helix884-91229
α-helix921-94121
α-helix948-9514
α-helix952-9587
α-helix959-9635
α-helix968-97710
α-helix979-100426
β-strand1010-101232
α-helix1027-10326
β-strand1036-103832
α-helix1047-105812
α-helix1063-107210
α-helix1086-10883
α-helix1089-10957
α-helix1096-11005
α-helix1106-112217
α-helix1132-114312
α-helix1158-116811
α-helix1170-118516
α-helix1186-11894
α-helix1198-122326
α-helix1225-12306
α-helix1232-124918
α-helix1262-12676
α-helix1268-127811
α-helix1280-12823
α-helix1283-132038
β-strand132713
β-strand133013
α-helix1339-134911
α-helix1355-13628
α-helix1384-139714
α-helix1398-14025
α-helix1405-142218
α-helix1427-143812
β-strand1447-144934
α-helix1450-14523
α-helix1453-14597
α-helix14611
α-helix14671
α-helix14691
α-helix1471-14766
β-strand1486-148834
α-helix1489-150416
α-helix1509-152012
Chain H: 0 helices, 2 β-strands
ElementResiduesLengthSheet
β-strand415
β-strand1615

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium channel protein PaFPC1Aprotein1596Periplaneta americanaD0E0C2 (AlphaFold model)
Delta-actitoxin-Avd2aHprotein27Anemonia sulcataP01535 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9LHZ_1 Sodium channel protein PaFPC1 (chains A)
MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGFDYKDDDDKGTMADNSPLIREERQRLFR
PYTRAMLTAPSAQPAKENGKTEENKDNSRDKGRGANKDRDGSAHPDQALEQGSRLPARMR
NIFPAELASTPLEDFDPFYKNKKTFVVVTKAGDIFRFSGEKSLWMLDPFTPIRRVAISTM
VQPIFSYFIMITILIHCIFMIMPATQTTYILELVFLSIYTIEVVVKVLARGFILHPFAYL
RDPWNWLDFLVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWRTIVDALSLSITS
LKDLVLLLLFSLFVFAVLGLQIYMGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWY
IPDDWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYW
EDLYQLALRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMSYTHMVKRADEEKAAERELK
KEKKAASVANNTANGQEQTTIEMNGDEAVVIDNNDQAARQQSDPETPAPSVTQRLTDFLC
VWDCCVPWQKLQGAIGAVVLSPFFELFIAVIIVLNITFMALDHHDMNIEFERILRTGNYI
FTSIYIVEAVLKIIALSPKFYFKDSWNVFDFIIVVFAILELGLEGVQGLSVFRSFRLLRV
FRLAKFWPTLNNFMSVMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNMERFPDG
DLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGDWSCIPFFVAVFFVGNLVILNLLI
ALLLNNYGSFCTSPTSDEEDSKDEDALAQIVRIFKRFKPNLNAVKLSPMKPDSEDIVESQ
EIQGNNIADAEDVLAGEFPPDCCCNAFYKCFPSRPARDSSVQRMWSNIRRVCFLLAKNKY
FQKFVTAVLVITSVLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKY
FTSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSKVNGMQVVTSTLVE
AVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTW
ENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHKQPIRETNIYMYLYFIFFIV
FGSFFILKLFVCILIDIFRQQRRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTC
HPQSLMYDISVNRKFEYTMMILIILNVAVMAIDHYGQSMEFSEVLDYLNLIFIIIFFVEC
VIKVSGLRHHYFKDPWNIIDFLYVVLAIAGLMLSDVIEKYFISPTLLRILRILRVGRLLR
YFQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHIRDAGAIDDVYNFK
TFGQSIILLFQLATSAGWDGVYFAIANEEDCRAPDHELGYPGNCGSRALGIAYLVSYLII
TCLVVINMYAAVILDYVLEVYEDSKEGLTDDDYDMFFEVWQQFDPEATQYIRYDQLSELL
EALQPPLQVQKPNKYKILSMNIPICKDDHIFYKDVLEALVKDVFSRRGSPVEAGDVQAPN
VDEAEYKPVSSTLQRQREEYCVRLIQNAWRKHKQQN
Sequence of entity 2 (H), FASTA
>9LHZ_2 Delta-actitoxin-Avd2a (chains H)
RSCCPCYWGGCPWGQNCYPEGCSGPKV

Ligands and cofactors

IDNameFormulaCopies
LPE1-O-octadecyl-sn-glycero-3-phosphocholineC26 H57 N O6 P1
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O63

Primary citation

Structure of voltage-gated sodium channel NavPas and sea anemone toxin Av3. Jiang, H. To be published.

Other PDB entries of the same protein (UniProt D0E0C2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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