Cryo-EM structure of the human TRPA1 ion channel in ligand-free state. Determined by electron microscopy at 3.1 Å resolution. Released 29 Oct 2025.
Explore 9M8S in 3D Show helices and sheets RCSB PDB PDBe
9M8S contains 140 α-helices and 16 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 448-455 | 8 | |
| α-helix | 459-466 | 8 | |
| α-helix | 485-492 | 8 | |
| α-helix | 495-503 | 9 | |
| α-helix | 512-514 | 3 | |
| α-helix | 517-524 | 8 | |
| α-helix | 527-534 | 8 | |
| α-helix | 551-558 | 8 | |
| α-helix | 561-569 | 9 | |
| α-helix | 583-589 | 7 | |
| α-helix | 593-601 | 9 | |
| α-helix | 605-610 | 6 | |
| α-helix | 622-629 | 8 | |
| α-helix | 631-640 | 10 | |
| β-strand | 657-659 | 3 | 3 |
| α-helix | 684-691 | 8 | |
| α-helix | 695-698 | 4 | |
| α-helix | 701-710 | 10 | |
| α-helix | 711-715 | 5 | |
| α-helix | 716-739 | 24 | |
| β-strand | 746 | 1 | 4 |
| β-strand | 751 | 1 | 4 |
| α-helix | 767-789 | 23 | |
| α-helix | 803-818 | 16 | |
| α-helix | 820-822 | 3 | |
| α-helix | 828-849 | 22 | |
| α-helix | 857-891 | 35 | |
| α-helix | 896-898 | 3 | |
| α-helix | 901-911 | 11 | |
| α-helix | 918 | 1 | |
| α-helix | 919-923 | 5 | |
| α-helix | 924-927 | 4 | |
| α-helix | 934-945 | 12 | |
| α-helix | 946-952 | 7 | |
| α-helix | 953-969 | 17 | |
| α-helix | 971-989 | 19 | |
| α-helix | 993-998 | 6 | |
| β-strand | 1002-1004 | 3 | 3 |
| α-helix | 1041-1071 | 31 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily A member 1 | A, B, C, D | protein | 1119 | Homo sapiens | O75762 (AlphaFold model) |
>9M8S_1 Transient receptor potential cation channel subfamily A member 1 (chains A, B, C, D) MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
Binding and Activating of Analgesic Crotalphine with Human TRPA1. Kang, M., Zhang, Y., Ding, X. et al. Membranes (Basel) (2025) 15. DOI 10.3390/membranes15060187 · PubMed
Other PDB entries of the same protein (UniProt O75762 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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