9N86: Human importin beta:importin alpha (IBB) complex

Cryo-EM structure of human importin beta:importin alpha (IBB) complex. Determined by electron microscopy at 3.3 Å resolution. Released 10 Dec 2025.

Method
Electron microscopy
Resolution
3.3 Å
Organism
Homo sapiens
Chains
2
Atoms
7,173
Mol. weight
103.61 kDa
Released
10 Dec 2025

Explore 9N86 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9N86 contains 55 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 53 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix3-119
α-helix16-3015
α-helix33-4412
α-helix51-6515
α-helix70-8112
α-helix85-9814
α-helix109-12012
α-helix129-13810
α-helix144-16017
α-helix164-1663
α-helix170-17910
α-helix189-20012
α-helix206-2105
α-helix212-22615
α-helix231-24717
α-helix250-2534
α-helix256-26914
α-helix273-30230
α-helix306-3072
α-helix314-3174
α-helix319-32911
α-helix344-35815
α-helix364-37310
α-helix380-39213
α-helix399-41618
α-helix422-43817
α-helix440-4434
α-helix446-45914
α-helix464-48421
α-helix498-5003
α-helix503-51412
α-helix521-5233
α-helix524-53714
α-helix544-56623
α-helix571-59424
α-helix597-61620
α-helix622-63918
α-helix640-6467
α-helix647-65812
α-helix664-68017
α-helix686-70116
α-helix709-72416
α-helix726-7305
α-helix732-74312
α-helix752-77726
α-helix783-7842
α-helix787-7937
α-helix794-80613
α-helix812-82817
α-helix831-8399
α-helix841-8433
α-helix844-8529
α-helix856-87318
Chain B: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix14-163
α-helix24-5027

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin subunit beta-1Aprotein876Homo sapiensQ14974 (AlphaFold model)
Importin subunit alpha-1Bprotein53Homo sapiensP52292 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9N86_1 Importin subunit beta-1 (chains A)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sequence of entity 2 (B), FASTA
>9N86_2 Importin subunit alpha-1 (chains B)
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNV

Primary citation

Ran modulates allosteric crosstalk between importin beta surfaces. Ko, Y.H., Li, F., Suinn, S.S. et al. Nat Commun (2025) 16:11425-11425. DOI 10.1038/s41467-025-66255-0 · PubMed

Other PDB entries of the same protein (UniProt Q14974 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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