9P7I: Elongation factor 1-alpha 1
In situ HHT and CHX treated human eEF1A-A/T-P-Z state 80S ribosome. Determined by electron microscopy at 3.69 Å resolution. Released 24 Dec 2025.
- Method
- Electron microscopy
- Resolution
- 3.69 Å
- Organism
- Homo sapiens
- Chains
- 86
- Atoms
- 225,029
- Mol. weight
- 3330.33 kDa
- Ligands
- ZN, HMT, 3HE, SPD
- Released
- 24 Dec 2025
Explore 9P7I in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9P7I contains 579 α-helices and 592 β-strands across 79 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain CF: 13 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-13 | 7 | 10 |
| α-helix | 22-31 | 10 | |
| α-helix | 36-47 | 12 | |
| α-helix | 52-54 | 3 | |
| α-helix | 64-69 | 6 | |
| β-strand | 77-81 | 5 | 10 |
| β-strand | 86-90 | 5 | 10 |
| α-helix | 99-107 | 9 | |
| β-strand | 111-114 | 4 | 10 |
| β-strand | 117 | 1 | 11 |
| α-helix | 123-126 | 4 | |
| α-helix | 132-143 | 12 | |
| β-strand | 148-152 | 5 | 10 |
| β-strand | 153 | 1 | 11 |
| α-helix | 155-157 | 3 | |
| α-helix | 164-181 | 18 | |
| β-strand | 189-192 | 4 | 10 |
| β-strand | 194 | 1 | 12 |
| β-strand | 199 | 1 | 12 |
| β-strand | 214-217 | 4 | 13 |
| β-strand | 222-225 | 4 | 13 |
| α-helix | 228-232 | 5 | |
| α-helix | 245-246 | 2 | |
| β-strand | 247-249 | 3 | 14 |
| β-strand | 252-256 | 5 | 15 |
| β-strand | 260-266 | 7 | 15 |
| β-strand | 269 | 1 | 14 |
| β-strand | 272 | 1 | 16 |
| β-strand | 277-280 | 4 | 14 |
| β-strand | 285-288 | 4 | 14 |
| β-strand | 289-294 | 6 | 15 |
| β-strand | 297-298 | 2 | 15 |
| β-strand | 302 | 1 | 16 |
| β-strand | 307-312 | 6 | 15 |
| β-strand | 325-328 | 4 | 14 |
| α-helix | 332-334 | 3 | |
| β-strand | 340-346 | 7 | 17 |
| β-strand | 360-363 | 4 | 17 |
| β-strand | 366-379 | 14 | 17 |
| β-strand | 386-389 | 4 | 17 |
| β-strand | 398-406 | 9 | 17 |
| α-helix | 419-422 | 4 | |
| β-strand | 424-428 | 5 | 17 |
| β-strand | 431-441 | 11 | 17 |
Chain CI: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 52-62 | 11 | |
| α-helix | 70-72 | 3 | |
Chain La: 6 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 8-11 | 4 | |
| α-helix | 42-48 | 7 | |
| β-strand | 72-74 | 3 | 36 |
| α-helix | 76-81 | 6 | |
| α-helix | 84-91 | 8 | |
| β-strand | 97-98 | 2 | 131 |
| β-strand | 100-102 | 3 | 37 |
| β-strand | 110-112 | 3 | 36 |
| β-strand | 123-126 | 4 | 37 |
| β-strand | 128-129 | 2 | 36 |
| α-helix | 131-139 | 9 | |
| β-strand | 143-146 | 4 | 37 |
Chain LA: 10 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 29-32 | 4 | |
| α-helix | 34-38 | 5 | |
| β-strand | 40-49 | 10 | 43 |
| β-strand | 58-64 | 7 | 43 |
| β-strand | 71-77 | 7 | 43 |
| β-strand | 79 | 1 | 44 |
| β-strand | 83 | 1 | 45 |
| β-strand | 87-91 | 5 | 43 |
| β-strand | 101-103 | 3 | 43 |
| α-helix | 104-106 | 3 | |
| β-strand | 112-113 | 2 | 46 |
| β-strand | 116-117 | 2 | 47 |
| β-strand | 124-126 | 3 | 47 |
| β-strand | 134-140 | 7 | 46 |
| α-helix | 142-144 | 3 | |
| β-strand | 145-149 | 5 | 46 |
| β-strand | 155-159 | 5 | 46 |
| β-strand | 163-165 | 3 | 43 |
| β-strand | 166 | 1 | 46 |
| β-strand | 169 | 1 | 44 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-190 | 9 | |
| α-helix | 201-203 | 3 | |
| α-helix | 206-208 | 3 | |
| β-strand | 225 | 1 | 48 |
| α-helix | 229-230 | 2 | |
| β-strand | 238 | 1 | 48 |
Chain Lb: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-18 | 7 | |
| α-helix | 22-24 | 3 | |
| α-helix | 37-48 | 12 | |
| α-helix | 54-73 | 20 | |
| α-helix | 92-100 | 9 | |
| α-helix | 106-117 | 12 | |
Chain LB: 19 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-10 | 2 | |
| α-helix | 14-16 | 3 | |
| α-helix | 32-35 | 4 | |
| α-helix | 40-41 | 2 | |
| β-strand | 42-43 | 2 | 52 |
| β-strand | 45-59 | 15 | 53 |
| β-strand | 71-80 | 10 | 53 |
| α-helix | 82-83 | 2 | |
| β-strand | 84-95 | 12 | 52 |
| β-strand | 98-106 | 9 | 52 |
| α-helix | 107 | 1 | |
| α-helix | 112-115 | 4 | |
| α-helix | 131-134 | 4 | |
| α-helix | 135-137 | 3 | |
| α-helix | 140-156 | 17 | |
| β-strand | 159-165 | 7 | 52 |
| α-helix | 168-170 | 3 | |
| α-helix | 177-179 | 3 | |
| β-strand | 180-186 | 7 | 52 |
| α-helix | 190-198 | 9 | |
| β-strand | 204-205 | 2 | 52 |
| α-helix | 207-209 | 3 | |
| β-strand | 216-222 | 7 | 53 |
| β-strand | 225-229 | 5 | 54 |
| α-helix | 231-234 | 4 | |
| α-helix | 237-241 | 5 | |
| β-strand | 270-273 | 4 | 54 |
| β-strand | 276-287 | 12 | 53 |
| β-strand | 292-293 | 2 | 55 |
| β-strand | 297-298 | 2 | 55 |
| α-helix | 300-303 | 4 | |
| β-strand | 320 | 1 | 56 |
| β-strand | 324 | 1 | 56 |
| β-strand | 330-334 | 5 | 53 |
| β-strand | 344-349 | 6 | 53 |
| β-strand | 365-368 | 4 | 53 |
| α-helix | 382-389 | 8 | |
| α-helix | 393-401 | 9 | |
Chain Lc: 4 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-21 | 12 | |
| β-strand | 26-29 | 4 | 57 |
| α-helix | 32-39 | 8 | |
| β-strand | 45-49 | 5 | 57 |
| α-helix | 54-67 | 14 | |
| β-strand | 70-74 | 5 | 57 |
| α-helix | 78-84 | 7 | |
| β-strand | 93-98 | 6 | 57 |
Chain LC: 25 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-11 | 5 | 62 |
| α-helix | 12 | 1 | |
| β-strand | 17-23 | 7 | 62 |
| α-helix | 24-25 | 2 | |
| α-helix | 26-29 | 4 | |
| α-helix | 31-32 | 2 | |
| α-helix | 34-45 | 12 | |
| β-strand | 65 | 1 | 63 |
| β-strand | 78 | 1 | 63 |
| β-strand | 90 | 1 | 63 |
| α-helix | 100-101 | 2 | |
| α-helix | 117-130 | 14 | |
| α-helix | 134-139 | 6 | |
| β-strand | 153-154 | 2 | 62 |
| α-helix | 156-160 | 5 | |
| α-helix | 164-173 | 10 | |
| α-helix | 177-185 | 9 | |
| β-strand | 188-189 | 2 | 64 |
| α-helix | 190-191 | 2 | |
| α-helix | 193-197 | 5 | |
| β-strand | 201-202 | 2 | 64 |
| β-strand | 208-211 | 4 | 62 |
| α-helix | 217-220 | 4 | |
| β-strand | 228-231 | 4 | 62 |
| α-helix | 232-234 | 3 | |
| α-helix | 237-240 | 4 | |
| β-strand | 250-253 | 4 | 62 |
| α-helix | 254-258 | 5 | |
| α-helix | 260-264 | 5 | |
| α-helix | 279-282 | 4 | |
| α-helix | 289-293 | 5 | |
| α-helix | 296-300 | 5 | |
| α-helix | 303-305 | 3 | |
| α-helix | 316-317 | 2 | |
| α-helix | 322-328 | 7 | |
| α-helix | 332-365 | 34 | |
71 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| P site tRNA [Homo sapiens] | Pt | RNA | 74 | Homo sapiens | |
| Elongation factor 1-alpha 1 | CF | protein | 441 | Homo sapiens | P68104 (AlphaFold model) |
| A/T site tRNA [Homo sapiens] | AT | RNA | 76 | Homo sapiens | |
| 28S rRNA [Homo sapiens] | L5 | RNA | 3655 | Homo sapiens | |
| 5S rRNA [Homo sapiens] | L7 | RNA | 120 | Homo sapiens | |
| 5.8S rRNA [Homo sapiens] | L8 | RNA | 156 | Homo sapiens | |
| 60S ribosomal protein L8 | LA | protein | 248 | Homo sapiens | P62917 (AlphaFold model) |
| Large ribosomal subunit protein uL3 | LB | protein | 402 | Homo sapiens | P39023 (AlphaFold model) |
| 60S ribosomal protein L4 | LC | protein | 368 | Homo sapiens | P36578 (AlphaFold model) |
| Large ribosomal subunit protein uL18 | LD | protein | 293 | Homo sapiens | P46777 |
| Large ribosomal subunit protein eL6 | LE | protein | 250 | Homo sapiens | Q02878 |
| 60S ribosomal protein L7 | LF | protein | 225 | Homo sapiens | P18124 |
74 more molecules are not listed.
Sequence of entity 1 (Pt), FASTA
>9P7I_1 P site tRNA [Homo sapiens] (chains Pt)
GUCUCCGUAGUGUAGGGUAUCACGUUCGCCUAACACGCGAAAGGUCCUCGGUUCGAAACC
GGGCGGAAACACCA
Sequence of entity 2 (CF), FASTA
>9P7I_2 Elongation factor 1-alpha 1 (chains CF)
EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKL
KAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEF
EAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGY
NPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTD
KPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEAL
PGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDC
HTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGR
FAVRDMRQTVAVGVIKAVDKK
Sequence of entity 3 (AT), FASTA
>9P7I_3 A/T site tRNA [Homo sapiens] (chains AT)
GUCUCCGUAGUGUAGCGGUUAUCACGUUCGCCUAACACGCGAAAGGUCCUCGGUUCGAAA
CCGGGCGGAAACACCA
Sequence of entity 4 (L5), FASTA
>9P7I_4 28S rRNA [Homo sapiens] (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCGCGGGGGACCGUCCCCCGACC
GGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCGGG
ACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGCCCCCGAGUGUUACAGCCCCCC
CGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGAGCGAGACCCGUCGCCGCGCUCUCC
CCCCUCGGGGGGGCCGGGCCACCCCUCCCACGGCGCGACCGCUCGGGGCGGACUGUCCCC
AGUGCGCCCCGGGCGGGUCGCGCCGUCGGGCCCGGGGGAGGCCACGCGCGCGUCCCCCGA
AGAGGGGGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACC
CGUCUUGAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAG
CCGCCGUGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAG
GCCUCUCCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGU
GGAGCACGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAA
GCCAGAGGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGAC
CUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUC
CCUCAGGAUAGCUGGCGCUCUCGCAGACCCGAGCCACGCAGUUUUAUCCGGUAAAGCGAA
UGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGUAAG
AAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACUUUU
GGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGCCGA
CGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAUGGA
AGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGAAAA
UGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGACGG
GAGCGGCGGCCGGAGCCCCGCGGACGCUACGCCGCGACGAGUAGGAGGGCCGCUGCGGUG
AGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGCAGGUGCAGAUCUUGGUGGU
AGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGGAGAAGGGUUCCAUGUGAAC
AGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGAGCGCCGUUCCGAAGGGACG
GGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUCGGGUUCAGAUCCCCGAAUC
CGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGUAACGCGACCGAUCCCGGAG
AAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUGAAGGGCAGGGCGCCCUGGA
AUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCGUCGCGGUUCCGGCGGCGUC
CGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGGUGUAAAUCUCGCGCCGGGC
CGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUCUGGCAUGUUGGAACAAUGU
AGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAUAAGGAUUGGCUCUAAGGGC
UGGGUCGGUCGCGGCCGGCGCCUAGCAGCCGACUUAGAACUGGUGCGGACCAGGGGAAUC
CGACUGUUUAAUUAAAACAAAGCAUCGCGAAGGCCCGCGGCGGGUGUUGACGCGAUGUGA
UUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCAAUGAAGCGCGGGUAAACGGC
GGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAUCUAAUUAGUGACGCGC
AUGAAXGGAUGAACGAGAUUCCCACUGUCCCUACCUACUAUCCAGCGAAACCACAGCCAA
GGGAACGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCUGUUGAGCUUGACUCUAGUCU
GGCACGGUGAAGAGACAUGAGAACUCUGAUCGUUUUUUCACUGACCCGGUGAGGCGGGGG
GGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGCGCGCCGGCCGGGC
GCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCAA
ACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUGGAGCAGA
AGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGAAAGCGGGGCC
UCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGUUACCACAGGG
AUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUCGAUGUC
GGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCACUAAUA
GGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAUG
UGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGACAUUUGGUG
UAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUUAUGACUGAAC
GCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCGCGGAGCCUCGGUU
GGCCUCGGAUAGCCGGUCCCCCGCCGGGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAA
CGGGGCGCGGCCGGAGAGGCGGCCGCCCCCUCGCCCGUCACGCACCGCACGUUCGUGGGG
AACCUGGCGCUAAACCAUUCGUAGACGACCUGCUUCUGGGUCGGGGUUUCGUACGUAGCA
GAGCAGCUCCCUCGCUGCGAUCUAUUGAAAGUCAGCCCUCGACACAAGGGUUUGU
Sequence of entity 5 (L7), FASTA
>9P7I_5 5S rRNA [Homo sapiens] (chains L7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
Sequence of entity 6 (L8), FASTA
>9P7I_6 5.8S rRNA [Homo sapiens] (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU
Sequence of entity 7 (LA), FASTA
>9P7I_7 60S ribosomal protein L8 (chains LA)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGRLRGT
Sequence of entity 8 (LB), FASTA
>9P7I_8 Large ribosomal subunit protein uL3 (chains LB)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 9 (LC), FASTA
>9P7I_9 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEK
Sequence of entity 10 (LD), FASTA
>9P7I_10 Large ribosomal subunit protein uL18 (chains LD)
GFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDII
CQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEG
QVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFP
GYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYK
KAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERA
Sequence of entity 11 (LE), FASTA
>9P7I_11 Large ribosomal subunit protein eL6 (chains LE)
KGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGG
DKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHR
GKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFK
KKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALT
NGIYPHKLVF
Sequence of entity 12 (LF), FASTA
>9P7I_12 60S ribosomal protein L7 (chains LF)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 6 |
| HMT | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cep… | C29 H39 N O9 | 1 |
| 3HE | 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2… | C15 H23 N O4 | 1 |
| SPD | Spermidine | C7 H19 N3 | 10 |
| SPM | Spermine | C10 H26 N4 | 7 |
| MG | Magnesium ion | Mg | 219 |
Primary citation
Visualizing the translation landscape in human cells at high resolution. Zheng, W., Zhang, Y., Wang, J. et al. Nat Commun (2025) 16:10757-10757. DOI 10.1038/s41467-025-65795-9 · PubMed
Other PDB entries of the same protein (UniProt P68104 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3C5J 1.8 Å, Crystal structure of HLA DR52c
- 9P8B 2.48 Å, In situ human eEF1A-A/T-P-E state 80S ribosome
- 8G60 2.54 Å, mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state)
- 9P7O 2.65 Å, In situ human AT-P-Z state ribosome
- 9PA7 2.67 Å, In situ human 80S consensus ribosome with EBP1
- 8G6J 2.8 Å, mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2)
- 9P7K 2.8 Å, In situ human post eEF1A-A/T-P-E state 80S ribosome
- 9P76 2.83 Å, In situ human eEF1A-A/T-P state 80S ribosome
- 9P7N 2.83 Å, In situ human Post-eEF1A-A/T-P-Z state 80S ribosome
- 9P7L 2.92 Å, In situ human Post-eEF1A-AT-P state 80S ribosome
- 6ZMO 3.1 Å, SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex
- 9P7H 3.68 Å, In situ HHT and CHX treated human eEF1A-A/T-P state 80S ribosome
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