9PCP: NER dual incision complex - NoG
NER dual incision complex - NoG. Determined by electron microscopy at 4.3 Å resolution. Released 1 Apr 2026.
- Method
- Electron microscopy
- Resolution
- 4.3 Å
- Organisms
- Homo sapiens, synthetic construct
- Chains
- 15
- Atoms
- 36,356
- Mol. weight
- 775.25 kDa
- Ligands
- SF4, ZN, CA
- Released
- 1 Apr 2026
Explore 9PCP in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9PCP contains 211 α-helices and 163 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 32 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 53 | 1 | 1 |
| β-strand | 59-60 | 2 | 1 |
| β-strand | 76-78 | 3 | 2 |
| β-strand | 83-87 | 5 | 2 |
| α-helix | 93-103 | 11 | |
| β-strand | 105-108 | 4 | 2 |
| β-strand | 113-117 | 5 | 2 |
| α-helix | 120-128 | 9 | |
| α-helix | 133-142 | 10 | |
| α-helix | 151-158 | 8 | |
| β-strand | 166-171 | 6 | 3 |
| β-strand | 174-179 | 6 | 3 |
| α-helix | 182-188 | 7 | |
| α-helix | 192-196 | 5 | |
| β-strand | 205-206 | 2 | 3 |
| β-strand | 268-272 | 5 | 3 |
| α-helix | 277-286 | 10 | |
| α-helix | 290 | 1 | |
| β-strand | 291-292 | 2 | 3 |
| β-strand | 294-295 | 2 | 4 |
| α-helix | 304-306 | 3 | |
| β-strand | 310 | 1 | 5 |
| α-helix | 315-317 | 3 | |
| α-helix | 318-327 | 10 | |
| β-strand | 333-334 | 2 | 4 |
| β-strand | 336-339 | 4 | 6 |
| α-helix | 346-357 | 12 | |
| β-strand | 362-365 | 4 | 6 |
| α-helix | 368-380 | 13 | |
| β-strand | 382 | 1 | 5 |
| α-helix | 386-388 | 3 | |
| β-strand | 389-392 | 4 | 6 |
| β-strand | 397 | 1 | 6 |
| β-strand | 405-409 | 5 | 6 |
| α-helix | 421-432 | 12 | |
| α-helix | 434 | 1 | |
| β-strand | 435-441 | 7 | 6 |
| α-helix | 443-445 | 3 | |
| α-helix | 452-457 | 6 | |
| β-strand | 460-467 | 8 | 6 |
| α-helix | 477-479 | 3 | |
| α-helix | 480-483 | 4 | |
| β-strand | 487-490 | 4 | 6 |
| α-helix | 493-498 | 6 | |
| β-strand | 506-512 | 7 | 7 |
| α-helix | 513-515 | 3 | |
| α-helix | 516-524 | 9 | |
| α-helix | 530-535 | 6 | |
| α-helix | 538-552 | 15 | |
| β-strand | 557-561 | 5 | 7 |
| α-helix | 565-574 | 10 | |
| β-strand | 579-580 | 2 | 7 |
| α-helix | 586-597 | 12 | |
| β-strand | 604-607 | 4 | 7 |
| β-strand | 620-625 | 6 | 7 |
| α-helix | 633-639 | 7 | |
| β-strand | 658-664 | 7 | 7 |
| α-helix | 669-676 | 8 | |
| α-helix | 678-683 | 6 | |
| β-strand | 687-690 | 4 | 7 |
| α-helix | 696-698 | 3 | |
| α-helix | 706-718 | 13 | |
Chain B: 35 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-5 | 3 | 8 |
| β-strand | 8-10 | 3 | 8 |
| α-helix | 17-18 | 2 | |
| α-helix | 19-33 | 15 | |
| β-strand | 38-40 | 3 | 9 |
| α-helix | 48-62 | 15 | |
| β-strand | 69-73 | 5 | 9 |
| β-strand | 74 | 1 | 10 |
| α-helix | 77-98 | 22 | |
| β-strand | 106-108 | 3 | 9 |
| α-helix | 127-135 | 9 | |
| α-helix | 144-146 | 3 | |
| α-helix | 156-164 | 9 | |
| α-helix | 169-171 | 3 | |
| β-strand | 174 | 1 | 9 |
| α-helix | 177-185 | 9 | |
| α-helix | 191-197 | 7 | |
| β-strand | 204-206 | 3 | 9 |
| β-strand | 208 | 1 | 10 |
| α-helix | 218-222 | 5 | |
| β-strand | 229-234 | 6 | 9 |
| α-helix | 239-246 | 8 | |
| β-strand | 249-252 | 4 | 11 |
| α-helix | 253-295 | 43 | |
| α-helix | 301-303 | 3 | |
| α-helix | 312-317 | 6 | |
| α-helix | 321-343 | 23 | |
| β-strand | 352 | 1 | 11 |
| α-helix | 356-364 | 9 | |
| α-helix | 375-385 | 11 | |
| α-helix | 395-409 | 15 | |
| β-strand | 417-419 | 3 | 11 |
| β-strand | 432-435 | 4 | 11 |
| α-helix | 440-443 | 4 | |
| α-helix | 445-450 | 6 | |
| β-strand | 455-457 | 3 | 9 |
| α-helix | 466-470 | 5 | |
| β-strand | 479 | 1 | 12 |
| β-strand | 492-495 | 4 | 13 |
| β-strand | 497 | 1 | 14 |
| β-strand | 503 | 1 | 14 |
| α-helix | 514-530 | 17 | |
| β-strand | 535-539 | 5 | 13 |
| α-helix | 542-554 | 13 | |
| α-helix | 558-564 | 7 | |
| β-strand | 566-569 | 4 | 13 |
| α-helix | 574-589 | 16 | |
| β-strand | 594-599 | 6 | 13 |
| β-strand | 617-621 | 5 | 13 |
| α-helix | 625-627 | 3 | |
| α-helix | 632-644 | 13 | |
| α-helix | 648-664 | 17 | |
| β-strand | 677-680 | 4 | 13 |
| α-helix | 683-685 | 3 | |
| α-helix | 687-690 | 4 | |
| α-helix | 695-698 | 4 | |
| α-helix | 703-706 | 4 | |
| β-strand | 708 | 1 | 13 |
| α-helix | 710-724 | 15 | |
| α-helix | 730-732 | 3 | |
Chain C: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 399-411 | 13 | |
| α-helix | 425-433 | 9 | |
| α-helix | 455-477 | 23 | |
| α-helix | 484-515 | 32 | |
| α-helix | 521-541 | 21 | |
Chain D: 24 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-22 | 4 | |
| α-helix | 28-34 | 7 | |
| α-helix | 38-46 | 9 | |
| α-helix | 50-57 | 8 | |
| α-helix | 65-66 | 2 | |
| α-helix | 80-92 | 13 | |
| β-strand | 97 | 1 | 15 |
| β-strand | 109 | 1 | 15 |
| α-helix | 114-119 | 6 | |
| α-helix | 145-164 | 20 | |
| α-helix | 173-182 | 10 | |
| β-strand | 185-186 | 2 | 16 |
| α-helix | 193-194 | 2 | |
| β-strand | 195-196 | 2 | 16 |
| α-helix | 197 | 1 | |
| α-helix | 198-204 | 7 | |
| α-helix | 208-221 | 14 | |
| α-helix | 224-226 | 3 | |
| α-helix | 232-240 | 9 | |
| β-strand | 249-250 | 2 | 17 |
| α-helix | 256-268 | 13 | |
| β-strand | 271-273 | 3 | 17 |
| β-strand | 280-283 | 4 | 17 |
| α-helix | 285-288 | 4 | |
| β-strand | 307-310 | 4 | 1 |
| β-strand | 314-317 | 4 | 1 |
| α-helix | 322-331 | 10 | |
| β-strand | 333-337 | 5 | 1 |
| β-strand | 342-345 | 4 | 1 |
| α-helix | 348-357 | 10 | |
| α-helix | 361-369 | 9 | |
| β-strand | 372 | 1 | 1 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-396 | 12 | |
| β-strand | 402-409 | 8 | 18 |
| α-helix | 415-428 | 14 | |
| β-strand | 431-435 | 5 | 18 |
| β-strand | 440-443 | 4 | 18 |
| α-helix | 448-461 | 14 | |
Chain E: 17 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-24 | 4 | |
| β-strand | 59-66 | 8 | 19 |
| α-helix | 70-72 | 3 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103-110 | 8 | 19 |
| β-strand | 113-121 | 9 | 19 |
| α-helix | 124-133 | 10 | |
| α-helix | 134-136 | 3 | |
| α-helix | 145-155 | 11 | |
| β-strand | 164-171 | 8 | 19 |
| α-helix | 185-192 | 8 | |
| β-strand | 194-200 | 7 | 19 |
| α-helix | 206-215 | 10 | |
| β-strand | 219-221 | 3 | 19 |
| α-helix | 225-234 | 10 | |
| α-helix | 238-239 | 2 | |
| α-helix | 253-255 | 3 | |
| β-strand | 256 | 1 | 20 |
| α-helix | 273-277 | 5 | |
| β-strand | 289-291 | 3 | 20 |
| β-strand | 296-298 | 3 | 20 |
| β-strand | 304 | 1 | 21 |
| β-strand | 311 | 1 | 21 |
| α-helix | 320-323 | 4 | |
| α-helix | 327-330 | 4 | |
| β-strand | 334 | 1 | 22 |
| β-strand | 344 | 1 | 23 |
| β-strand | 351 | 1 | 23 |
| β-strand | 357 | 1 | 22 |
| β-strand | 358-360 | 3 | 24 |
| β-strand | 365-367 | 3 | 24 |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 383-386 | 4 | |
Chain F: 9 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-17 | 11 | 25 |
| α-helix | 19-27 | 9 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-63 | 8 | 25 |
| β-strand | 67-69 | 3 | 25 |
| α-helix | 102-120 | 19 | |
| α-helix | 133-150 | 18 | |
| β-strand | 156-165 | 10 | 25 |
| α-helix | 174-186 | 13 | |
| β-strand | 190-195 | 6 | 25 |
| α-helix | 201-210 | 10 | |
| β-strand | 214-216 | 3 | 25 |
| α-helix | 223-229 | 7 | |
| α-helix | 235-238 | 4 | |
| β-strand | 254 | 1 | 26 |
| β-strand | 261 | 1 | 26 |
| α-helix | 285-287 | 3 | |
Chain G: 2 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-11 | 7 | 18 |
| α-helix | 14-26 | 13 | |
| β-strand | 34-36 | 3 | 18 |
| β-strand | 42-45 | 4 | 18 |
| α-helix | 50-63 | 14 | |
Chain H: 22 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 172-224 | 53 | |
| α-helix | 227-236 | 10 | |
| α-helix | 239-242 | 4 | |
| α-helix | 251-264 | 14 | |
| β-strand | 266-267 | 2 | 27 |
| α-helix | 279-289 | 11 | |
| β-strand | 291-292 | 2 | 27 |
| α-helix | 295-306 | 12 | |
| β-strand | 313-318 | 6 | 28 |
| β-strand | 531-536 | 6 | 28 |
| β-strand | 541-545 | 5 | 28 |
| β-strand | 552 | 1 | 28 |
| α-helix | 555-560 | 6 | |
| β-strand | 569-572 | 4 | 28 |
| β-strand | 578-580 | 3 | 28 |
| α-helix | 582-584 | 3 | |
| α-helix | 589-593 | 5 | |
| α-helix | 600-606 | 7 | |
| α-helix | 615-627 | 13 | |
| β-strand | 657-659 | 3 | 29 |
| β-strand | 669 | 1 | 30 |
| β-strand | 674 | 1 | 30 |
| β-strand | 681-683 | 3 | 29 |
| α-helix | 687-692 | 6 | |
| β-strand | 695-697 | 3 | 31 |
| β-strand | 705-707 | 3 | 32 |
| α-helix | 714-720 | 7 | |
| α-helix | 724-727 | 4 | |
| β-strand | 730-732 | 3 | 32 |
| β-strand | 738-740 | 3 | 31 |
| α-helix | 743-744 | 2 | |
| β-strand | 745 | 1 | 33 |
| β-strand | 747 | 1 | 34 |
| β-strand | 750 | 1 | 34 |
| β-strand | 759-760 | 2 | 35 |
| α-helix | 764-766 | 3 | |
| α-helix | 767-768 | 2 | |
| β-strand | 769 | 1 | 33 |
| β-strand | 771-774 | 4 | 36 |
| α-helix | 779-786 | 8 | |
| β-strand | 791 | 1 | 36 |
| β-strand | 793-798 | 6 | 35 |
| α-helix | 800-802 | 3 | |
| β-strand | 805-808 | 4 | 35 |
| β-strand | 811-814 | 4 | 36 |
| α-helix | 819-858 | 40 | |
| α-helix | 890-901 | 12 | |
| α-helix | 904-907 | 4 | |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| TFIIH basal transcription factor complex helicase XPB subunit | A | protein | 782 | Homo sapiens | P19447 (AlphaFold model) |
| General transcription and DNA repair factor IIH helicase subunit XPD | B | protein | 768 | Homo sapiens | P18074 (AlphaFold model) |
| General transcription factor IIH subunit 1 | C | protein | 548 | Homo sapiens | P32780 (AlphaFold model) |
| General transcription factor IIH subunit 4, p52 | D | protein | 462 | Homo sapiens | Q92759 (AlphaFold model) |
| General transcription factor IIH subunit 2 | E | protein | 395 | Homo sapiens | Q13888 |
| General transcription factor IIH subunit 3 | F | protein | 308 | Homo sapiens | Q13889 |
| General transcription factor IIH subunit 5 | G | protein | 71 | Homo sapiens | Q6ZYL4 |
| DNA repair protein complementing XP-C cells | H | protein | 940 | Homo sapiens | Q01831 |
| UV excision repair protein RAD23 homolog B | I | protein | 409 | Homo sapiens | P54727 |
| Centrin-2 | J | protein | 172 | Homo sapiens | P41208 |
| DNA repair protein complementing XP-A cells | K | protein | 273 | Homo sapiens | P23025 |
| DNA (Cy5) | L | DNA | 93 | synthetic construct | |
3 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>9PCP_1 TFIIH basal transcription factor complex helicase XPB subunit (chains A)
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA
YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESC
HPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG
KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRND
SVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR
CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRS
WEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL
NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNK
FRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP
KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFY
SLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT
DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRF
RK
Sequence of entity 2 (B), FASTA
>9PCP_2 General transcription and DNA repair factor IIH helicase subunit XPD (chains B)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQLDYKDDDDK
Sequence of entity 3 (C), FASTA
>9PCP_3 General transcription factor IIH subunit 1 (chains C)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKT
Sequence of entity 4 (D), FASTA
>9PCP_4 General transcription factor IIH subunit 4, p52 (chains D)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Sequence of entity 5 (E), FASTA
>9PCP_5 General transcription factor IIH subunit 2 (chains E)
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
Sequence of entity 6 (F), FASTA
>9PCP_6 General transcription factor IIH subunit 3 (chains F)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA
Sequence of entity 7 (G), FASTA
>9PCP_7 General transcription factor IIH subunit 5 (chains G)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK
Sequence of entity 8 (H), FASTA
>9PCP_8 DNA repair protein complementing XP-C cells (chains H)
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGC
SHPGGSADGPAKKKVAKVTVKSENLKVIKDEALSDGDDLRDFPSDLKKAHHLKRGATMNE
DSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSE
KIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPAR
FTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVH
IFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKP
KTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGR
ERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGS
KSASRTHRGSHRKDPSLPVASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEE
KWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDA
EWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIY
PETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLA
EPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLH
RVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKK
EKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARIL
AASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEKL
Sequence of entity 9 (I), FASTA
>9PCP_9 UV excision repair protein RAD23 homolog B (chains I)
MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALK
EYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPT
STPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDA
TSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVD
PPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLP
ALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYI
QVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDED
Sequence of entity 10 (J), FASTA
>9PCP_10 Centrin-2 (chains J)
MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRAL
GFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGK
ISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY
Sequence of entity 11 (K), FASTA
>9PCP_11 DNA repair protein complementing XP-A cells (chains K)
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
Sequence of entity 12 (L), FASTA
>9PCP_12 DNA (Cy5) (chains L)
GCTGCGGTCCGTTGACGACATACAGCTCAACGATGCCACTTCAGCATTGCACTCATGTTC
TGXCACTAGTACTACGACTACGCCTCGGCTCGA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| ZN | Zinc ion | Zn | 6 |
| CA | Calcium ion | Ca | 2 |
Primary citation
Pre-incision structures reveal principles of DNA nucleotide excision repair. Li, E.C.L., Kim, J., Brussee, S.J. et al. Nature (2026) 652:1060-1067. DOI 10.1038/s41586-026-10122-5 · PubMed
Other PDB entries of the same protein (UniProt P19447 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4ERN 1.8 Å, Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein…
- 7NVV 2.9 Å, XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)
- 28JM 3.29 Å, Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
- 7EGB 3.3 Å, TFIID-based holo PIC on SCP promoter
- 8EBU 3.3 Å, XPC release from Core7-XPA-DNA (Cy5)
- 9PD3 3.3 Å, NER dual incision complex - DuIS
- 28JS 3.32 Å, Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA…
- 9PD4 3.4 Å, NER dual incision complex - DuIM
- 6RO4 3.5 Å, Structure of the core TFIIH-XPA-DNA complex
- 7AD8 3.5 Å, Core TFIIH-XPA-DNA complex with modelled p62 subunit
- 9XYU 3.5 Å, NER complex - C7CAD.ATP
- 28KE 3.6 Å, Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA
Browse structure collections
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