9PD3: NER dual incision complex - DuIS
NER dual incision complex - DuIS. Determined by electron microscopy at 3.3 Å resolution. Released 18 Feb 2026.
- Method
- Electron microscopy
- Resolution
- 3.3 Å
- Organisms
- Homo sapiens, synthetic construct
- Chains
- 17
- Atoms
- 35,072
- Mol. weight
- 930.85 kDa
- Ligands
- ZN, SF4
- Released
- 18 Feb 2026
Explore 9PD3 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9PD3 contains 209 α-helices and 178 β-strands across 15 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 30 helices, 34 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 53 | 1 | 1 |
| β-strand | 59-60 | 2 | 1 |
| β-strand | 76-78 | 3 | 2 |
| β-strand | 83-87 | 5 | 2 |
| α-helix | 93-103 | 11 | |
| β-strand | 105-108 | 4 | 2 |
| β-strand | 113-117 | 5 | 2 |
| α-helix | 120-128 | 9 | |
| α-helix | 133-141 | 9 | |
| α-helix | 150-158 | 9 | |
| β-strand | 166-171 | 6 | 3 |
| β-strand | 174-179 | 6 | 3 |
| α-helix | 182-190 | 9 | |
| α-helix | 192-196 | 5 | |
| β-strand | 268-272 | 5 | 3 |
| α-helix | 277-286 | 10 | |
| α-helix | 290 | 1 | |
| β-strand | 291-292 | 2 | 3 |
| β-strand | 294-295 | 2 | 4 |
| α-helix | 304-306 | 3 | |
| β-strand | 310 | 1 | 5 |
| α-helix | 318-327 | 10 | |
| β-strand | 333-334 | 2 | 4 |
| β-strand | 336-339 | 4 | 6 |
| α-helix | 346-357 | 12 | |
| β-strand | 361 | 1 | 7 |
| β-strand | 362-365 | 4 | 6 |
| α-helix | 368-381 | 14 | |
| β-strand | 382 | 1 | 5 |
| α-helix | 386-388 | 3 | |
| β-strand | 389-391 | 3 | 7 |
| β-strand | 392 | 1 | 8 |
| β-strand | 397 | 1 | 8 |
| β-strand | 405-407 | 3 | 7 |
| β-strand | 408-409 | 2 | 6 |
| α-helix | 421-432 | 12 | |
| β-strand | 435-441 | 7 | 6 |
| α-helix | 443-445 | 3 | |
| α-helix | 452-457 | 6 | |
| β-strand | 460-467 | 8 | 6 |
| α-helix | 477-479 | 3 | |
| α-helix | 480-483 | 4 | |
| β-strand | 487-490 | 4 | 6 |
| α-helix | 493-499 | 7 | |
| β-strand | 505-510 | 6 | 9 |
| β-strand | 511-512 | 2 | 10 |
| α-helix | 513-515 | 3 | |
| α-helix | 516-522 | 7 | |
| α-helix | 530-535 | 6 | |
| α-helix | 538-552 | 15 | |
| β-strand | 557-562 | 6 | 9 |
| α-helix | 565-575 | 11 | |
| β-strand | 579-580 | 2 | 9 |
| α-helix | 586-597 | 12 | |
| β-strand | 604-607 | 4 | 9 |
| β-strand | 620-627 | 8 | 9 |
| α-helix | 633-639 | 7 | |
| β-strand | 657-661 | 5 | 9 |
| β-strand | 663-664 | 2 | 10 |
| α-helix | 669-676 | 8 | |
| α-helix | 678-683 | 6 | |
| β-strand | 688-690 | 3 | 9 |
| α-helix | 696-698 | 3 | |
| α-helix | 706-718 | 13 | |
Chain B: 37 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-5 | 3 | 11 |
| β-strand | 8-10 | 3 | 11 |
| α-helix | 19-33 | 15 | |
| β-strand | 38-41 | 4 | 12 |
| α-helix | 48-62 | 15 | |
| β-strand | 69-74 | 6 | 12 |
| α-helix | 77-98 | 22 | |
| β-strand | 106-108 | 3 | 12 |
| α-helix | 112-114 | 3 | |
| α-helix | 127-138 | 12 | |
| α-helix | 140-144 | 5 | |
| α-helix | 145-148 | 4 | |
| α-helix | 156-164 | 9 | |
| α-helix | 177-187 | 11 | |
| α-helix | 191-198 | 8 | |
| β-strand | 204-208 | 5 | 12 |
| α-helix | 209-211 | 3 | |
| α-helix | 215-221 | 7 | |
| β-strand | 229-234 | 6 | 12 |
| α-helix | 239-246 | 8 | |
| β-strand | 249-252 | 4 | 13 |
| α-helix | 253-283 | 31 | |
| α-helix | 322-345 | 24 | |
| β-strand | 351-352 | 2 | 13 |
| α-helix | 354-364 | 11 | |
| α-helix | 369-373 | 5 | |
| α-helix | 375-386 | 12 | |
| α-helix | 392-394 | 3 | |
| α-helix | 395-409 | 15 | |
| β-strand | 415-418 | 4 | 13 |
| β-strand | 432-436 | 5 | 13 |
| α-helix | 440-442 | 3 | |
| α-helix | 445-450 | 6 | |
| β-strand | 453-458 | 6 | 12 |
| α-helix | 466-470 | 5 | |
| β-strand | 479-481 | 3 | 12 |
| β-strand | 490-494 | 5 | 14 |
| β-strand | 495 | 1 | 15 |
| α-helix | 514-528 | 15 | |
| β-strand | 535-539 | 5 | 14 |
| α-helix | 542-554 | 13 | |
| α-helix | 558-564 | 7 | |
| β-strand | 566-569 | 4 | 14 |
| α-helix | 574-589 | 16 | |
| β-strand | 594-599 | 6 | 14 |
| α-helix | 603-607 | 5 | |
| β-strand | 617-621 | 5 | 14 |
| α-helix | 631-642 | 12 | |
| α-helix | 648-665 | 18 | |
| β-strand | 675-679 | 5 | 14 |
| α-helix | 682-685 | 4 | |
| α-helix | 687-690 | 4 | |
| α-helix | 695-698 | 4 | |
| α-helix | 704-706 | 3 | |
| β-strand | 708 | 1 | 15 |
| α-helix | 710-725 | 16 | |
| α-helix | 727-728 | 2 | |
| α-helix | 730-734 | 5 | |
Chain C: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 399-412 | 14 | |
| α-helix | 424-434 | 11 | |
| α-helix | 455-478 | 24 | |
| α-helix | 479 | 1 | |
| α-helix | 481 | 1 | |
| α-helix | 484-515 | 32 | |
| α-helix | 521-541 | 21 | |
Chain D: 22 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-24 | 6 | |
| α-helix | 28-35 | 8 | |
| α-helix | 38-47 | 10 | |
| α-helix | 50-58 | 9 | |
| β-strand | 66-67 | 2 | 16 |
| α-helix | 68-72 | 5 | |
| β-strand | 75 | 1 | 17 |
| α-helix | 80-93 | 14 | |
| β-strand | 96-100 | 5 | 16 |
| β-strand | 106-110 | 5 | 16 |
| α-helix | 112-122 | 11 | |
| α-helix | 145-164 | 20 | |
| α-helix | 173-182 | 10 | |
| β-strand | 185-186 | 2 | 18 |
| α-helix | 193-194 | 2 | |
| β-strand | 195-196 | 2 | 18 |
| α-helix | 198-205 | 8 | |
| α-helix | 208-226 | 19 | |
| α-helix | 230-241 | 12 | |
| β-strand | 250 | 1 | 19 |
| α-helix | 256-268 | 13 | |
| β-strand | 271-273 | 3 | 20 |
| β-strand | 280 | 1 | 19 |
| β-strand | 281-283 | 3 | 20 |
| α-helix | 285-291 | 7 | |
| β-strand | 307-309 | 3 | 1 |
| β-strand | 314-317 | 4 | 1 |
| α-helix | 323-331 | 9 | |
| β-strand | 333-337 | 5 | 1 |
| β-strand | 342-345 | 4 | 1 |
| α-helix | 348-356 | 9 | |
| α-helix | 361-370 | 10 | |
| β-strand | 372 | 1 | 1 |
| α-helix | 374-378 | 5 | |
| α-helix | 385-398 | 14 | |
| β-strand | 402-409 | 8 | 21 |
| α-helix | 415-428 | 14 | |
| β-strand | 431-435 | 5 | 21 |
| β-strand | 440-443 | 4 | 21 |
| α-helix | 448-461 | 14 | |
Chain E: 17 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-24 | 3 | |
| β-strand | 58-66 | 9 | 22 |
| α-helix | 69-72 | 4 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103-110 | 8 | 22 |
| β-strand | 113-121 | 9 | 22 |
| α-helix | 124-133 | 10 | |
| α-helix | 134-136 | 3 | |
| α-helix | 137-139 | 3 | |
| α-helix | 145-156 | 12 | |
| β-strand | 163-171 | 9 | 22 |
| α-helix | 182-191 | 10 | |
| β-strand | 195-200 | 6 | 22 |
| α-helix | 206-214 | 9 | |
| β-strand | 219 | 1 | 22 |
| α-helix | 225-234 | 10 | |
| α-helix | 238-239 | 2 | |
| β-strand | 250-251 | 2 | 23 |
| β-strand | 270-271 | 2 | 24 |
| α-helix | 273-277 | 5 | |
| β-strand | 284-285 | 2 | 24 |
| β-strand | 289-290 | 2 | 25 |
| β-strand | 297-298 | 2 | 25 |
| β-strand | 304 | 1 | 26 |
| β-strand | 311 | 1 | 26 |
| α-helix | 317-324 | 8 | |
| α-helix | 327-330 | 4 | |
| β-strand | 334-335 | 2 | 27 |
| β-strand | 344 | 1 | 28 |
| β-strand | 351 | 1 | 28 |
| β-strand | 356-357 | 2 | 27 |
| β-strand | 358-359 | 2 | 29 |
| β-strand | 366-367 | 2 | 29 |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 383-386 | 4 | |
Chain F: 12 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-17 | 11 | 30 |
| α-helix | 19-28 | 10 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-63 | 8 | 30 |
| β-strand | 67-69 | 3 | 30 |
| α-helix | 102-119 | 18 | |
| α-helix | 133-150 | 18 | |
| β-strand | 156-165 | 10 | 30 |
| α-helix | 168-170 | 3 | |
| α-helix | 174-186 | 13 | |
| β-strand | 190-195 | 6 | 30 |
| α-helix | 201-210 | 10 | |
| β-strand | 214-216 | 3 | 30 |
| α-helix | 224-226 | 3 | |
| α-helix | 227-231 | 5 | |
| α-helix | 235-240 | 6 | |
| β-strand | 241 | 1 | 17 |
| α-helix | 244-246 | 3 | |
| β-strand | 254 | 1 | 31 |
| β-strand | 261 | 1 | 31 |
| β-strand | 266-267 | 2 | 23 |
| β-strand | 274 | 1 | 23 |
| α-helix | 284-288 | 5 | |
Chain G: 3 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-11 | 7 | 21 |
| α-helix | 14-26 | 13 | |
| β-strand | 34-36 | 3 | 21 |
| β-strand | 42-45 | 4 | 21 |
| α-helix | 47-49 | 3 | |
| α-helix | 50-64 | 15 | |
Chain H: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 893-901 | 9 | |
| α-helix | 904-907 | 4 | |
7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| TFIIH basal transcription factor complex helicase XPB subunit | A | protein | 782 | Homo sapiens | P19447 (AlphaFold model) |
| General transcription and DNA repair factor IIH helicase subunit XPD | B | protein | 768 | Homo sapiens | P18074 (AlphaFold model) |
| General transcription factor IIH subunit 1 | C | protein | 548 | Homo sapiens | P32780 (AlphaFold model) |
| General transcription factor IIH subunit 4, p52 | D | protein | 462 | Homo sapiens | Q92759 (AlphaFold model) |
| General transcription factor IIH subunit 2 | E | protein | 395 | Homo sapiens | Q13888 |
| General transcription factor IIH subunit 3 | F | protein | 308 | Homo sapiens | Q13889 |
| General transcription factor IIH subunit 5 | G | protein | 71 | Homo sapiens | Q6ZYL4 |
| DNA repair protein complementing XP-C cells | H | protein | 940 | Homo sapiens | Q01831 |
| DNA repair protein complementing XP-A cells | K | protein | 273 | Homo sapiens | P23025 |
| DNA lesion strand | L | DNA | 51 | synthetic construct | |
| DNA normal strand | M | DNA | 53 | synthetic construct | |
| Replication protein A 70 kDa DNA-binding subunit | N | protein | 616 | Homo sapiens | P27694 |
5 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>9PD3_1 TFIIH basal transcription factor complex helicase XPB subunit (chains A)
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA
YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESC
HPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG
KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRND
SVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR
CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRS
WEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL
NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNK
FRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP
KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFY
SLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT
DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRF
RK
Sequence of entity 2 (B), FASTA
>9PD3_2 General transcription and DNA repair factor IIH helicase subunit XPD (chains B)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQLDYKDDDDK
Sequence of entity 3 (C), FASTA
>9PD3_3 General transcription factor IIH subunit 1 (chains C)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKT
Sequence of entity 4 (D), FASTA
>9PD3_4 General transcription factor IIH subunit 4, p52 (chains D)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Sequence of entity 5 (E), FASTA
>9PD3_5 General transcription factor IIH subunit 2 (chains E)
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
Sequence of entity 6 (F), FASTA
>9PD3_6 General transcription factor IIH subunit 3 (chains F)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA
Sequence of entity 7 (G), FASTA
>9PD3_7 General transcription factor IIH subunit 5 (chains G)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK
Sequence of entity 8 (H), FASTA
>9PD3_8 DNA repair protein complementing XP-C cells (chains H)
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGC
SHPGGSADGPAKKKVAKVTVKSENLKVIKDEALSDGDDLRDFPSDLKKAHHLKRGATMNE
DSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSE
KIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPAR
FTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVH
IFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKP
KTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGR
ERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGS
KSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEE
KWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDA
EWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIY
PETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLA
EPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLH
RVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKK
EKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARIL
AASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL
Sequence of entity 9 (K), FASTA
>9PD3_9 DNA repair protein complementing XP-A cells (chains K)
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
Sequence of entity 10 (L), FASTA
>9PD3_10 DNA lesion strand (chains L)
GCTCAACGATGCCACTTCAGCATTGCACTCATGTTCTGCACTAGTACTACG
Sequence of entity 11 (M), FASTA
>9PD3_11 DNA normal strand (chains M)
CGTAGTACTAGTGTTAAGAGCGTGAGTACAATGCTGAAGTGGCATCGTTGAGC
Sequence of entity 12 (N), FASTA
>9PD3_12 Replication protein A 70 kDa DNA-binding subunit (chains N)
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 7 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
Primary citation
Pre-incision structures reveal principles of DNA nucleotide excision repair. Li, E.C.L., Kim, J., Brussee, S.J. et al. Nature (2026) 652:1060-1067. DOI 10.1038/s41586-026-10122-5 · PubMed
Other PDB entries of the same protein (UniProt P19447 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4ERN 1.8 Å, Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein…
- 7NVV 2.9 Å, XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)
- 28JM 3.29 Å, Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
- 7EGB 3.3 Å, TFIID-based holo PIC on SCP promoter
- 8EBU 3.3 Å, XPC release from Core7-XPA-DNA (Cy5)
- 28JS 3.32 Å, Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA…
- 9PD4 3.4 Å, NER dual incision complex - DuIM
- 6RO4 3.5 Å, Structure of the core TFIIH-XPA-DNA complex
- 7AD8 3.5 Å, Core TFIIH-XPA-DNA complex with modelled p62 subunit
- 9XYU 3.5 Å, NER complex - C7CAD.ATP
- 28KE 3.6 Å, Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA
- 8EBX 3.6 Å, XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP)
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