9RKH: Beta-2 adrenergic receptor,Endolysin

Dark structure of beta-2 Adrenergic receptor with photoazolol in Dark state recorded at LCLS. Determined by X-ray diffraction at 2.5 Å resolution. Released 22 Apr 2026.

Method: X-ray diffraction
Resolution: 2.5 Å
Organisms: Homo sapiens, Enterobacteria phage T4
Chains: 1
Atoms: 3,909
Mol. weight: 56.7 kDa
Ligands: PLM, A1JHU, OLC, CLR
Released: 22 Apr 2026

Explore 9RKH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9RKH contains 26 α-helices and 6 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 26 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	30-60	31
α-helix	62-64	3
α-helix	67-85	19
α-helix	87-96	10
α-helix	102-135	34
α-helix	147-170	24
α-helix	179-186	8
α-helix	197-204	8
α-helix	205-209	5
α-helix	210-228	19
α-helix	232-239	8
β-strand	243-244	2	1
β-strand	245	1	2
β-strand	246-248	3	1
β-strand	254-257	4	1
β-strand	260-263	4	1
α-helix	268-279	12
β-strand	286	1	2
α-helix	289-309	21
α-helix	314-319	6
α-helix	322-340	19
α-helix	344-351	8
α-helix	355-363	9
α-helix	366-370	5
α-helix	372-384	13
α-helix	388-390	3
α-helix	395-426	32
α-helix	433-445	13
α-helix	446-448	3
α-helix	450-453	4
α-helix	454-456	3
α-helix	458-467	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Beta-2 adrenergic receptor,Endolysin	A	protein	442	Homo sapiens, Enterobacteria phage T4	P00720, P07550 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9RKH_1 Beta-2 adrenergic receptor,Endolysin (chains A)
DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVP
FGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIWTLCVIAVDRYFAITSPFKYQSLLTKN
KARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSF
YVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSL
NAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAAL
INMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWD
AYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSG
FNPLIYCRSPDFRIAFQELLCL

Ligands and cofactors

ID	Name	Formula	Copies
PLM	Palmitic acid	C16 H32 O2	1
A1JHU	~{N}-[4-[(~{E})-[2-[(2~{S})-2-oxidanyl-3-(propan-2-ylamino)propoxy]phenyl]diaze…	C20 H26 N4 O3	1
OLC	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	C21 H40 O4	7
CLR	Cholesterol	C27 H46 O	2

Water and common crystallization additives (SO4, 12P, EDO, GOL) are not listed.

Primary citation

Structural Mechanism of an Efficacy Photoswitch Targeting the beta 2 -adrenergic Receptor. Stipp, R., Bertrand, Q., Trabuco, M. et al. Angew Chem Int Ed Engl (2026) 65:e17995-e17995. DOI 10.1002/anie.202517995 · PubMed

Other PDB entries of the same protein (UniProt P00720), best resolution first:

2O7A 0.84 Å, T4 lysozyme C-terminal fragment
5JDT 1.0 Å, Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at 100K
7LOE 1.01 Å, T4 lysozyme mutant L99A in complex with 1-fluoranylnaphthalene
7LOD 1.02 Å, T4 lysozyme mutant L99A in complex with 1-fluoranyl-4-iodanyl-benzene
7LX8 1.03 Å, T4 lysozyme mutant L99A
5XPF 1.04 Å, High-resolution X-ray structure of the T26H mutant of T4 lysozyme
6BG3 1.05 Å, Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl…
7LOF 1.05 Å, T4 lysozyme mutant L99A in complex with 2-butylthiophene
7LX6 1.05 Å, T4 lysozyme mutant L99A
7LX7 1.05 Å, T4 lysozyme mutant L99A
1SWY 1.06 Å, Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure…
1SWZ 1.06 Å, Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure…

Browse structure collections

About this viewer

MolViewer shows 9RKH directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.