9S3G: DNA-directed RNA polymerase subunit

Name: PDB 9S3G: State 1 MAP3 RNA Pol II activated elongation complex with SETD2 and upstream hexasome
Published: 2025-11-12
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

State 1 MAP3 RNA Pol II activated elongation complex with SETD2 and upstream hexasome. Determined by electron microscopy at 6.4 Å resolution. Released 12 Nov 2025.

Method: Electron microscopy
Resolution: 6.4 Å
Organisms: Sus scrofa, Homo sapiens, synthetic construct
Chains: 34
Atoms: 75,297
Mol. weight: 1863.7 kDa
Ligands: ZN, MG
Released: 12 Nov 2025

Explore 9S3G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9S3G contains 429 α-helices and 444 β-strands across 31 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	47-55	9
α-helix	65-79	15
β-strand	84-85	2	36
α-helix	87-114	28
β-strand	120	1	37
α-helix	122-132	11

Chain A: 85 helices, 77 β-strands

Element	Residues	Length	Sheet
β-strand	15-16	2	1
β-strand	21-22	2	2
β-strand	25	1	3
α-helix	26-27	2
α-helix	28-34	7
β-strand	43	1	4
β-strand	47-49	3	5
β-strand	51-52	2	5
α-helix	53	1
β-strand	56	1	4
α-helix	81-85	5
β-strand	86-95	10	6
α-helix	100-109	10
β-strand	110	1	7
α-helix	111	1
β-strand	117	1	7
α-helix	124-132	9
α-helix	137-147	11
β-strand	153	1	8
α-helix	186	1
β-strand	187	1	8
α-helix	188-189	2
β-strand	190-194	5	9
β-strand	197-201	5	9
β-strand	213-216	4	9
α-helix	218-227	10
α-helix	230-235	6
α-helix	240-243	4
α-helix	245-248	4
β-strand	249-255	7	6
α-helix	258-260	3
β-strand	264	1	10
β-strand	272	1	10
α-helix	273-274	2
α-helix	275-295	21
α-helix	300-318	19
α-helix	326-328	3
β-strand	329-330	2	11
β-strand	334-335	2	11
α-helix	339-343	5
α-helix	349-354	6
β-strand	358-359	2	12
β-strand	362-369	8	13
β-strand	377-381	5	13
α-helix	382-387	6
β-strand	389-393	5	14
α-helix	399-408	10
β-strand	416-420	5	14
β-strand	426-428	3	14
α-helix	429-431	3
α-helix	435-438	4
β-strand	445-449	5	14
α-helix	450	1
β-strand	455-459	5	13
α-helix	466-469	4
β-strand	471-477	7	13
β-strand	482-484	3	13
α-helix	489-492	4
β-strand	500-504	5	13
α-helix	509-518	10
β-strand	520	1	13
α-helix	521-524	4
β-strand	526	1	15
β-strand	533	1	15
α-helix	540-548	9
β-strand	554-555	2	16
α-helix	557-563	7
α-helix	564-566	3
α-helix	574	1
β-strand	575	1	17
α-helix	576-577	2
β-strand	579-581	3	18
β-strand	585	1	18
β-strand	586-587	2	16
α-helix	588-595	8
β-strand	602-604	3	19
β-strand	628-631	4	19
β-strand	634-637	4	19
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
β-strand	686	1	20
α-helix	689-691	3
α-helix	698-721	24
α-helix	725-728	4
α-helix	733-759	27
α-helix	765-771	7
α-helix	778-781	4
α-helix	782-786	5
β-strand	789-790	2	21
β-strand	793	1	22
β-strand	796	1	22
α-helix	798-799	2
β-strand	802	1	23
β-strand	805	1	23
α-helix	811	1
α-helix	818-820	3
β-strand	822-823	2	21
α-helix	833-868	36
β-strand	872-873	2	24
β-strand	879-880	2	24
β-strand	886-888	3	24
α-helix	891-893	3
β-strand	896	1	25
β-strand	902-905	4	26
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	27
α-helix	936-944	9
α-helix	946-969	24
α-helix	971-973	3
β-strand	976-979	4	26
α-helix	983-993	11
β-strand	1002	1	27
α-helix	1006-1019	14
α-helix	1028-1048	21
α-helix	1051-1052	2
α-helix	1053-1058	6
α-helix	1062-1079	18
β-strand	1080	1	25
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1098-1100	3
α-helix	1120-1129	10
β-strand	1138	1	28
β-strand	1140-1142	3	29
β-strand	1143	1	30
α-helix	1146-1148	3
α-helix	1151-1161	11
β-strand	1164-1165	2	31
α-helix	1166-1169	4
β-strand	1170-1177	8	32
α-helix	1181-1183	3
α-helix	1187-1197	11
β-strand	1207-1216	10	32
α-helix	1218-1222	5
α-helix	1228-1238	11
β-strand	1243-1247	5	32
β-strand	1255-1262	8	32
α-helix	1265-1269	5
α-helix	1281-1295	15
β-strand	1297-1299	3	31
β-strand	1306-1310	5	29
α-helix	1315-1317	3
β-strand	1319-1320	2	33
β-strand	1330-1331	2	33
β-strand	1335-1339	5	29
β-strand	1340	1	28
α-helix	1343-1348	6
β-strand	1352	1	30
β-strand	1358	1	29
α-helix	1362-1388	27
α-helix	1395-1404	10
β-strand	1408-1409	2	34
α-helix	1416-1419	4
α-helix	1426-1431	6
α-helix	1435-1444	10
β-strand	1448-1449	2	2
α-helix	1454-1459	6
α-helix	1467-1469	3
β-strand	1471-1475	5	35
α-helix	1479-1481	3

Chain b: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	26-29	4
α-helix	32-41	10
β-strand	47	1	37
α-helix	49-76	28
β-strand	81-82	2	36
α-helix	84-93	10
β-strand	98-99	2	61

Chain B: 57 helices, 79 β-strands

Element	Residues	Length	Sheet
α-helix	19-36	18
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-68	4	38
α-helix	69-71	3
β-strand	83-93	11	38
β-strand	97-99	3	39
β-strand	105-107	3	39
α-helix	110-115	6
β-strand	121-133	13	38
β-strand	142-153	12	38
α-helix	154-155	2
α-helix	168-173	6
β-strand	185-187	3	40
β-strand	190-194	5	40
α-helix	195	1
β-strand	196-200	5	41
α-helix	201	1
β-strand	204-208	5	42
β-strand	215-223	9	42
β-strand	233-240	8	42
β-strand	256-259	4	42
β-strand	267-268	2	42
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-307	13
α-helix	314-325	12
α-helix	332-341	10
α-helix	342-346	5
α-helix	349-351	3
α-helix	358-377	20
α-helix	381-383	3
α-helix	388-390	3
β-strand	391-394	4	41
α-helix	396-423	28
α-helix	431-434	4
α-helix	438-450	13
β-strand	453	1	43
α-helix	456-461	6
β-strand	463	1	43
β-strand	467-469	3	40
α-helix	475-482	8
β-strand	484-486	3	41
α-helix	490	1
α-helix	503-505	3
β-strand	509	1	44
β-strand	524-525	2	41
β-strand	526	1	44
β-strand	527	1	45
β-strand	531-532	2	46
α-helix	539-547	9
β-strand	550-552	3	47
α-helix	558-561	4
β-strand	565-569	5	47
β-strand	572-577	6	47
α-helix	580-591	12
β-strand	602-606	5	47
β-strand	611-615	5	47
β-strand	621-627	7	46
β-strand	628-630	3	48
β-strand	632-633	2	48
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	46
α-helix	669-671	3
β-strand	675-676	2	46
β-strand	695-696	2	46
α-helix	700-703	4
β-strand	705	1	45
α-helix	707-710	4
α-helix	714-716	3
β-strand	717	1	49
α-helix	719-728	10
β-strand	732	1	50
β-strand	748-751	4	51
β-strand	759-760	2	52
α-helix	762-765	4
β-strand	776-782	7	53
β-strand	783	1	20
β-strand	794-797	4	53
α-helix	798-802	5
β-strand	808-817	10	51
β-strand	827-829	3	54
β-strand	837-838	2	54
α-helix	845-847	3
β-strand	848	1	55
β-strand	853	1	56
β-strand	854	1	55
α-helix	855	1
β-strand	859	1	51
β-strand	865-867	3	56
β-strand	869-872	4	54
β-strand	889-891	3	54
β-strand	894-895	2	56
α-helix	896-897	2
β-strand	903-911	9	51
β-strand	917-927	11	51
β-strand	934-937	4	53
β-strand	943-949	7	53
β-strand	956	1	57
β-strand	965-967	3	53
α-helix	971-975	5
β-strand	977	1	49
α-helix	978-993	16
β-strand	997-998	2	52
α-helix	1008-1016	9
β-strand	1025-1026	2	58
α-helix	1028	1
β-strand	1029	1	57
α-helix	1030	1
α-helix	1035	1
β-strand	1036	1	57
α-helix	1037	1
α-helix	1040	1
β-strand	1041-1042	2	58
β-strand	1043-1050	8	53
β-strand	1051	1	50
α-helix	1055-1057	3
β-strand	1060-1061	2	13
β-strand	1067	1	59
β-strand	1074	1	59
β-strand	1084-1085	2	12
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
α-helix	1126	1
β-strand	1127-1129	3	60
β-strand	1134-1136	3	60
β-strand	1146-1150	5	1
α-helix	1153-1163	11
β-strand	1167	1	3
β-strand	1170	1	2

Chain C: 13 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	62
β-strand	18-24	7	62
α-helix	28-39	12
β-strand	43-55	13	63
α-helix	61-69	9
β-strand	73	1	64
α-helix	78-81	4
α-helix	83-84	2
α-helix	85-87	3
β-strand	99-106	8	63
α-helix	112	1
β-strand	113-115	3	65
α-helix	117-119	3
β-strand	121-122	2	63
β-strand	129	1	64
α-helix	146-148	3
β-strand	151-153	3	65
β-strand	158-169	12	63
α-helix	174-176	3
β-strand	179-182	4	62
β-strand	185	1	62
α-helix	200-202	3
α-helix	203-206	4
α-helix	218-220	3
β-strand	229-235	7	62
α-helix	241-268	28

Chain D: 8 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	68
β-strand	21	1	68
α-helix	24-26	3
β-strand	30-31	2	35
α-helix	34-50	17
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain e: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	65-79	15
β-strand	84-85	2	66
α-helix	87-114	28
β-strand	119-120	2	67
α-helix	122-132	11

Chain E: 12 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	3-23	21
β-strand	26	1	69
α-helix	30-34	5
α-helix	37-44	8
α-helix	55-58	4
β-strand	60-64	5	69
β-strand	67-75	9	69
β-strand	82	1	70
α-helix	84-97	14
β-strand	101-106	6	69
β-strand	110	1	70
α-helix	112-120	9
β-strand	127-131	5	69
α-helix	132-135	4
α-helix	139-141	3
β-strand	147-150	4	34
α-helix	151-152	2
α-helix	153-162	10
α-helix	167-169	3
β-strand	172-173	2	34
α-helix	178-182	5
β-strand	190-197	8	34
β-strand	201-209	9	34

23 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1174	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	142	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A8D1KNW4
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A4X1VYD0
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A8D0JYF1

20 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9S3G_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>9S3G_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>9S3G_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>9S3G_4 RNA polymerase II subunit D (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>9S3G_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>9S3G_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>9S3G_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>9S3G_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>9S3G_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>9S3G_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>9S3G_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>9S3G_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	9
MG	Magnesium ion	Mg	1

Primary citation

Molecular mechanism of co-transcriptional H3K36 methylation by SETD2. Walshe, J.L., Ochmann, M., Neef, U. et al. Nat Commun (2025) 16:9565-9565. DOI 10.1038/s41467-025-65439-y · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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