9T66: F-box/WD repeat-containing protein

Complex linking two repeat units of a cytoplasmic lattice filament. Determined by electron microscopy at 5.3 Å resolution. Released 12 Aug 2026.

Method: Electron microscopy
Resolution: 5.3 Å
Organism: Mus musculus
Chains: 40
Atoms: 89,612
Mol. weight: 2323.23 kDa
Released: 12 Aug 2026

Explore 9T66 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9T66 contains 760 α-helices and 1,005 β-strands across 40 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 45 helices, 34 β-strands

Element	Residues	Length	Sheet
α-helix	98-108	11
α-helix	114-116	3
α-helix	120-129	10
β-strand	133	1	225
β-strand	136	1	225
β-strand	140-145	6	226
α-helix	151-163	13
β-strand	175	1	226
α-helix	179-181	3
β-strand	187-189	3	227
α-helix	190-197	8
α-helix	202-210	9
α-helix	211-213	3
β-strand	216-218	3	226
α-helix	223-228	6
β-strand	243-245	3	227
α-helix	246-255	10
β-strand	263-269	7	226
α-helix	270-279	10
β-strand	284-289	6	226
α-helix	293-303	11
α-helix	310-319	10
α-helix	321-327	7
α-helix	330-346	17
α-helix	357-372	16
α-helix	378-380	3
α-helix	381-400	20
β-strand	406	1	228
α-helix	407-412	6
α-helix	417-424	8
β-strand	430-432	3	228
β-strand	439-441	3	228
α-helix	445-458	14
α-helix	459-461	3
α-helix	465-467	3
α-helix	486-498	13
α-helix	501-511	11
α-helix	519-531	13
α-helix	539-551	13
α-helix	555-561	7
β-strand	566	1	229
β-strand	569-572	4	230
α-helix	575-585	11
β-strand	591	1	229
β-strand	593-598	6	230
α-helix	624-638	15
β-strand	644-646	3	230
β-strand	650	1	230
α-helix	654-664	11
β-strand	673-675	3	230
α-helix	684-694	11
β-strand	700-702	3	230
β-strand	703-704	2	231
α-helix	710-721	12
β-strand	729	1	230
β-strand	732-733	2	231
α-helix	739-750	12
β-strand	757-759	3	230
α-helix	767-778	12
β-strand	786-790	5	230
α-helix	796-806	11
β-strand	814-818	5	230
α-helix	824-835	12
β-strand	843-846	4	230
α-helix	853-865	13
β-strand	871-874	4	230
α-helix	881-892	12
β-strand	900-903	4	230
α-helix	910-922	13
β-strand	928-931	4	230
α-helix	937-950	14
β-strand	957-960	4	230
α-helix	967-979	13
β-strand	985-987	3	230
α-helix	995-1005	11
β-strand	1014-1016	3	230
α-helix	1019-1021	3
α-helix	1024-1036	13
β-strand	1041-1043	3	230

Chain A: 28 helices, 50 β-strands

Element	Residues	Length	Sheet
β-strand	6-7	2	54
β-strand	15-20	6	55
β-strand	21	1	54
β-strand	24-28	5	54
β-strand	39-44	6	55
β-strand	48-51	4	54
β-strand	56-58	3	54
β-strand	64-68	5	55
β-strand	74-79	6	54
β-strand	89-96	8	55
β-strand	105-114	10	55
β-strand	115-119	5	56
α-helix	134-138	5
β-strand	141	1	57
β-strand	147	1	57
β-strand	149-151	3	58
β-strand	153	1	56
α-helix	166-169	4
α-helix	171-172	2
β-strand	179-186	8	56
α-helix	189-194	6
β-strand	195-200	6	58
α-helix	203-208	6
β-strand	209-214	6	56
β-strand	221-223	3	56
β-strand	231-233	3	58
β-strand	242-249	8	56
β-strand	254	1	59
β-strand	257	1	59
β-strand	260-269	10	58
β-strand	279-280	2	58
β-strand	284-290	7	58
α-helix	291-293	3
β-strand	294	1	60
β-strand	302-308	7	61
α-helix	311-313	3
α-helix	314-327	14
β-strand	331-334	4	61
α-helix	341	1
α-helix	344-348	5
β-strand	349-355	7	60
β-strand	360-366	7	60
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	60
α-helix	404-406	3
β-strand	407-409	3	62
β-strand	413-415	3	63
β-strand	418-420	3	63
β-strand	425-427	3	62
α-helix	442-451	10
β-strand	458	1	62
β-strand	464	1	64
α-helix	469-471	3
β-strand	473-477	5	65
β-strand	488-494	7	65
α-helix	495-505	11
α-helix	506-510	5
β-strand	514	1	66
α-helix	521-527	7
β-strand	533	1	66
α-helix	534-539	6
α-helix	541-565	25
α-helix	569-571	3
β-strand	572-576	5	65
β-strand	579-583	5	64
α-helix	589-591	3
β-strand	596-600	5	64
α-helix	603-604	2
β-strand	609-611	3	67
β-strand	613-618	6	67
α-helix	630-642	13
β-strand	645-649	5	67
α-helix	652-656	5
α-helix	657-658	2
β-strand	666-670	5	61
α-helix	671-673	3
α-helix	677-679	3

Chain b: 5 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	147-149	3
α-helix	158-176	19
α-helix	250-252	3
α-helix	275-278	4
β-strand	283-286	4	233
β-strand	290-291	2	233
β-strand	298-302	5	234
β-strand	307-311	5	234
β-strand	315-320	6	234
β-strand	328	1	233
β-strand	334-336	3	234
β-strand	349-351	3	235
β-strand	357-360	4	235
β-strand	367	1	236
β-strand	369-372	4	235
β-strand	379-382	4	235
β-strand	385	1	236
β-strand	393-396	4	237
β-strand	402-405	4	237
β-strand	411-415	5	237
β-strand	420-425	6	237
β-strand	434-437	4	238
β-strand	441-445	5	238
β-strand	450-455	6	238
β-strand	460-461	2	238
β-strand	465-466	2	238
β-strand	471-476	6	239
β-strand	482-487	6	239
β-strand	492-496	5	239
β-strand	504-505	2	239
α-helix	512	1
β-strand	513-518	6	240
β-strand	524-529	6	240
β-strand	533-538	6	240
β-strand	544-549	6	240
β-strand	556-559	4	233
β-strand	565-569	5	233
β-strand	573-580	8	233

Chain B: 27 helices, 51 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	78
β-strand	6-7	2	79
β-strand	14-15	2	80
β-strand	18-20	3	78
β-strand	24-28	5	79
β-strand	39-44	6	80
β-strand	48-52	5	79
β-strand	55-58	4	79
β-strand	65-68	4	80
β-strand	74-79	6	79
β-strand	89-97	9	80
β-strand	100-111	12	80
β-strand	112-114	3	78
β-strand	116-119	4	81
α-helix	135-138	4
β-strand	149-151	3	82
β-strand	153	1	81
α-helix	157-159	3
α-helix	165-169	5
α-helix	175-177	3
β-strand	179-185	7	81
α-helix	189-194	6
β-strand	195-200	6	82
α-helix	203-208	6
β-strand	209-213	5	81
β-strand	222-225	4	81
β-strand	226	1	83
β-strand	229	1	83
β-strand	232-233	2	82
β-strand	242-249	8	81
β-strand	254	1	84
β-strand	257	1	84
β-strand	260-269	10	82
β-strand	273	1	85
β-strand	276	1	85
β-strand	279-290	12	82
β-strand	294	1	86
α-helix	301	1
β-strand	302-308	7	87
α-helix	314-327	14
β-strand	333-334	2	87
α-helix	344-348	5
β-strand	349-356	8	86
β-strand	359-366	8	86
α-helix	377-381	5
α-helix	383	1
β-strand	387-388	2	86
α-helix	404-406	3
β-strand	407-409	3	88
α-helix	410-412	3
β-strand	413-415	3	89
β-strand	418-420	3	89
β-strand	425-427	3	88
α-helix	442-449	8
β-strand	457	1	88
β-strand	464	1	90
α-helix	469-471	3
β-strand	473-477	5	91
β-strand	488-493	6	91
α-helix	495-505	11
α-helix	506-510	5
α-helix	521-527	7
α-helix	534-539	6
α-helix	541-565	25
α-helix	569-571	3
β-strand	572-575	4	91
β-strand	579-582	4	90
β-strand	597-600	4	90
α-helix	603-604	2
β-strand	609-611	3	92
β-strand	614-618	5	92
α-helix	630-643	14
β-strand	645-649	5	92
α-helix	652-655	4
α-helix	657-658	2
β-strand	665-670	6	87
α-helix	671-673	3
α-helix	677-679	3

Chain c: 31 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	4-9	6	247
α-helix	10-14	5
α-helix	15-27	13
β-strand	35	1	248
α-helix	38-40	3
α-helix	46-49	4
α-helix	50-52	3
β-strand	53-55	3	249
α-helix	56	1
β-strand	60	1	248
β-strand	61-63	3	249
β-strand	65-69	5	247
α-helix	73-79	7
α-helix	84-86	3
α-helix	89-91	3
β-strand	92-94	3	247
α-helix	103-104	2
α-helix	105-110	6
α-helix	111-128	18
β-strand	134-140	7	247
α-helix	144	1
α-helix	145-149	5
α-helix	150-161	12
β-strand	165-172	8	247
α-helix	175-177	3
α-helix	183-195	13
β-strand	200-205	6	247
α-helix	206-217	12
α-helix	224-243	20
α-helix	252-259	8
β-strand	269-273	5	250
β-strand	277	1	251
α-helix	278-280	3
α-helix	288-296	9
α-helix	298-300	3
β-strand	301	1	250
α-helix	307-309	3
β-strand	312	1	252
β-strand	316-321	6	250
α-helix	325-338	14
β-strand	343	1	252
β-strand	353-356	4	250
α-helix	359-360	2
β-strand	368	1	251
β-strand	373-379	7	250
β-strand	381	1	252
α-helix	382-384	3
α-helix	385-400	16
α-helix	405-411	7
α-helix	415-436	22
α-helix	437-439	3

Chain d: 26 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	2-9	8	253
α-helix	11-27	17
β-strand	30	1	254
β-strand	35	1	255
β-strand	36	1	254
α-helix	41-44	4
α-helix	47-49	3
β-strand	51-54	4	255
β-strand	58-61	4	255
β-strand	63-67	5	253
α-helix	70-78	9
α-helix	82-84	3
α-helix	87-89	3
β-strand	90-92	3	253
α-helix	101-102	2
α-helix	103-107	5
α-helix	109-126	18
β-strand	129-138	10	253
α-helix	142	1
α-helix	143-147	5
α-helix	148-158	11
β-strand	164-170	7	253
α-helix	173-175	3
α-helix	181-195	15
β-strand	199-203	5	253
α-helix	204-209	6
α-helix	210-214	5
α-helix	222-241	20
α-helix	250-257	8
α-helix	261-263	3
β-strand	265-266	2	253
β-strand	267-271	5	256
α-helix	286-293	8
α-helix	296-298	3
β-strand	299	1	256
β-strand	310-318	9	256
α-helix	323-336	14
β-strand	349-354	6	256
α-helix	357-358	2
β-strand	364-371	8	256
α-helix	374-391	18
α-helix	395-401	7
α-helix	405-427	23

Chain e: 12 helices, 32 β-strands

Element	Residues	Length	Sheet
α-helix	7-16	10
α-helix	19-28	10
α-helix	30-36	7
α-helix	39-48	10
α-helix	60	1
α-helix	66-82	17
α-helix	85-87	3
β-strand	88-93	6	14
β-strand	104-107	4	15
β-strand	120-125	6	15
β-strand	129-134	6	15
β-strand	139-143	5	15
α-helix	150	1
β-strand	151-157	7	16
α-helix	158-160	3
β-strand	162-167	6	16
β-strand	171-175	5	16
β-strand	184-187	4	16
α-helix	191	1
β-strand	192-200	9	17
β-strand	203-210	8	17
β-strand	214-218	5	17
β-strand	225-230	6	17
β-strand	238-241	4	18
β-strand	247-251	5	18
β-strand	260-263	4	18
α-helix	264-268	5
α-helix	270-272	3
β-strand	278-280	3	18
β-strand	286-291	6	19
β-strand	298-305	8	19
β-strand	310-323	14	19
β-strand	326-339	14	19
β-strand	347-351	5	20
β-strand	356-360	5	20
β-strand	364-369	6	20
β-strand	377-379	3	20
β-strand	385-390	6	21
β-strand	394-399	6	21
β-strand	404-409	6	21
β-strand	416-422	7	21
β-strand	436-440	5	14
β-strand	443-450	8	14
β-strand	453-462	10	14

Chain E: 28 helices, 54 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	98
β-strand	6-7	2	99
β-strand	15-18	4	98
β-strand	21	1	99
β-strand	24-27	4	99
α-helix	29-32	4
β-strand	39-43	5	98
β-strand	48-52	5	99
β-strand	56-57	2	99
α-helix	59-61	3
β-strand	64-68	5	98
β-strand	75-79	5	99
β-strand	89-96	8	98
β-strand	105-112	8	98
β-strand	115-119	5	100
α-helix	134-138	5
β-strand	149-151	3	101
β-strand	153	1	100
α-helix	157-159	3
α-helix	166-169	4
β-strand	179-186	8	100
α-helix	189-194	6
β-strand	195-200	6	101
α-helix	203-207	5
β-strand	209-213	5	100
β-strand	222	1	100
β-strand	226	1	102
β-strand	229	1	102
β-strand	231-233	3	101
α-helix	234-236	3
β-strand	242-249	8	100
β-strand	254	1	103
β-strand	257	1	103
β-strand	260-269	10	101
α-helix	270-271	2
β-strand	279-290	12	101
α-helix	291-293	3
β-strand	294	1	104
α-helix	301	1
β-strand	302-308	7	105
α-helix	314-327	14
β-strand	331-333	3	105
α-helix	344-348	5
β-strand	349-355	7	104
β-strand	360-366	7	104
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	104
α-helix	404-406	3
β-strand	408-409	2	106
β-strand	413-415	3	107
β-strand	418-420	3	107
β-strand	425-426	2	106
β-strand	427-429	3	108
β-strand	439	1	108
α-helix	442-451	10
β-strand	458-460	3	108
β-strand	464	1	109
α-helix	469-471	3
β-strand	473-477	5	110
β-strand	488-494	7	110
α-helix	495-508	14
β-strand	514	1	111
α-helix	521-527	7
β-strand	533	1	111
α-helix	534-539	6
α-helix	541-564	24
α-helix	569-571	3
β-strand	572-576	5	110
β-strand	579-583	5	109
α-helix	589-591	3
β-strand	596-600	5	109
β-strand	609-611	3	112
β-strand	614-618	5	112
β-strand	624	1	113
β-strand	629	1	113
α-helix	630-642	13
β-strand	645-649	5	112
α-helix	652-656	5
β-strand	665-670	6	105
α-helix	671-673	3
α-helix	677-679	3

32 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
F-box/WD repeat-containing protein	e, g, q, s	protein	466	Mus musculus
Inactive protein-arginine deiminase type-6	A, B, E, F, I, J, K, L	protein	682	Mus musculus	Q8K3V4 (AlphaFold model)
Oocyte-expressed protein homolog	O, R, Z, i	protein	164	Mus musculus	Q9CWE6 (AlphaFold model)
KH domain-containing protein 3	S, j	protein	440	Mus musculus	Q9CWU5 (AlphaFold model)
Tubulin alpha-1C chain	c, o	protein	449	Mus musculus	P68373 (AlphaFold model)
Tubulin beta-4B chain	d, p	protein	445	Mus musculus	P68372
S-phase kinase-associated protein 1	f, h, r, t	protein	163	Mus musculus	Q9WTX5
NLR family, pyrin domain containing 4F	Y, n	protein	937	Mus musculus	L7N1W9
Zinc finger BED domain-containing protein 3	T, W, k, m	protein	228	Mus musculus	Q9D0L1
NACHT, LRR and PYD domains-containing protein 5	M, P, U, a	protein	1163	Mus musculus	Q9R1M5
Transducin-like enhancer protein 6	N, Q, X, b	protein	581	Mus musculus	Q9WVB3

Sequence of entity 1 (e, g, q, s), FASTA

>9T66_1 F-box/WD repeat-containing protein (chains e, g, q, s)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

Sequence of entity 2 (A, B, E, F, I, J, K, L), FASTA

>9T66_2 Inactive protein-arginine deiminase type-6 (chains A, B, E, F, I, J, K, L)
MSFQNSLSLSLVNPTHALCMVGMEITLDISKCAPDKCKSFTIRGSPRILIHISSSVIAGK
EDTVVWRSMNHPTVALVRMVAPSPTVDEDKVLVSYFCPDQEVPTATAVLFLTGIEISLEA
DIYRDGQLDMPSDKQAKKKWMWGMNGWGAILLVNCSPNAVGQPDEQSFQEGPREIQNLSQ
MNVTVEGPTSILQNYQLILHTSEEEAKKTRVYWSQRGSSAYELVVGPNKPVYLLPTFENR
RKEAFYVEATEFPSPSFSGLISLSLSLVEKAHDECIPEIPLYKDTVMFRVAPYIFMPSTQ
MPLEVYLCRELQLQGFVDSVTKLSEKSKVQVVKVYEDPNRQSKWLQDEMAFCYTQAPHKT
VSLILDTPRVSKLEDFPMKYTLTPGSGYLIRQTEDHRVASLDSIGNLMVSPPVKAQGKDY
PLGRVLIGGSFYPSSEGRDMNKGLREFVYAQQVQAPVELFSDWLMTGHMDQFMCFVPTND
KNNDQKDFRLLLASPSACFELFEQKQKEGYGNVTLFEDIGAEQLLSNGRESKTISQILAD
KSFREQNTYVEKCISLNRTLLKTELGLEDKDIILIPQLFCLEQLTNVPSNQQSTKLFARP
YFPDMLQIIVLGKNLGIPKPFGPKINGTCCLEEKVCGLLEPLGLKCTFIDDFDCYLANIG
DVCASAIINRVPFAFKWWKMTP

Sequence of entity 3 (O, R, Z, i), FASTA

>9T66_3 Oocyte-expressed protein homolog (chains O, R, Z, i)
MASHTADADAKPDSDSQKLLNVLPVSLRLRTRPWWFPIQEVSNPLVLYMEAWVAERVIGT
DQAEISEIEWMCQALLTVDSVNSGNLAEITIFGQPSAQTRMKNILLNMAAWHKENELQRA
VKVKEVEEFLKIRASSILSKLSKKGLKLAGFPLPLEGRETQMES

Sequence of entity 4 (S, j), FASTA

>9T66_4 KH domain-containing protein 3 (chains S, j)
MASLKRFQTLVPLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGE
HIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRMLTDLAHYCRMKLMEIEALE
AGVERRRMAAHKAATQPAPVKVREAAPRPASVKVPETATQPAPVKVREAAPQPAPVQEVR
EAAPQQASVQEEVREAATEQAPVQEVREAATEQAPVQEVSEAATEQAPVQEVNEAATEQA
SVQAVREAATRPAPGKVRKAATQPAPVQVCQEATQLAPVKVREAATQPASGKVREAATQL
APVKVRKAATQLAPVKVHEAATQPAPGKVSDAATQSASVQVREAATQLSPVEATDTSQLA
QVKADEAFAQHTSGEAHQVANGQSPIEVCETATGQHSLDVSRALSQKCPEVFEWETQSCL
DGSYVIVQPPRDAWESFIIL

Sequence of entity 5 (c, o), FASTA

>9T66_5 Tubulin alpha-1C chain (chains c, o)
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSAEGDDEGEEY

Sequence of entity 6 (d, p), FASTA

>9T66_6 Tubulin beta-4B chain (chains d, p)
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA

Sequence of entity 7 (f, h, r, t), FASTA

>9T66_7 S-phase kinase-associated protein 1 (chains f, h, r, t)
MPTIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQ
WCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTC
KTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK

Sequence of entity 8 (Y, n), FASTA

>9T66_8 NLR family, pyrin domain containing 4F (chains Y, n)
MASFISDFGLIWYLRELNKKEFMKFKDFLIQEILELKLKQVSSTKVKKASREDLANLLLK
CGENQAWDMTFRILQKINRKDLTERATGAIVGNPNLYRDHLKKKLTHDCPKKFNVRIQDF
IKETFIQNDYDAFENLLISKGTERKPHMVFLKGMAGVGKTLMLKNLMLAWSKGLVFQNKF
SYAFYFCCQDVKQLKTASLAELISREWPSPSAPIEEILSQPEKLLFIIDSLEGMEWDLTK
QESELCDDCMEKQPVSTLLSSLLRRKMLPESSLLLSTTPETFEKMEDRIQCTDVKTATAF
DERSMKIYFHRLFQDRKRAQEAFSLVRENKQLFTICQVPLLCWMVATCLKEEIEKGGDPV
SLCRRTTSLYTTHIFSLFIPQSAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFGKEALRRN
GIFDSDIPTLLDIGMLGKIREFENSYIFLHPSVQEVCAAIFYMLKRHVEHPSQDVKNIET
VLFMFLKKVKTQWIFLGCFIFGLLQKSEQEKLGVFFGHRLSKNIHHKLYQCLETLSGNAE
LQEQIDGMRLFSCLFEMEDEAFLVKAMNCMQQINFVAKNYSDFIVAAYCLKHCSTLKKLS
FSTENVLNEGDQSYMEELLICWNNMCSVFVRSKDIQELRIKDTNFNEPAIRVLYESLKYP
SFTLNKLVANNVSFGDNHVLFELIQNSSLQYLDLSCSFLSHNEVKLLCDILNQAECNIEK
LMIAHCKLSPDDCKIFGSILMSSKSLKVLNLASNNLNQGISSLCKALCHPHCTLEYLVLS
NCSLSEQCWDYLSEVLRQNKTLSHLDISSNDLKDEGLKILCRSLILPYCVLESLCLSCCG
ITERGCQDLAEVLKNNQNLKYLHVSYNKLKDTGVMLLCDAIKHPNCHLKDLQLEACEITD
ASNEELCYAFMQCETLQTLNLMGNAFEVSRMVFFPRF

Sequence of entity 9 (T, W, k, m), FASTA

>9T66_9 Zinc finger BED domain-containing protein 3 (chains T, W, k, m)
MKSKKPLKITMEDSRRLNDPAEQGGLCPAPVGPSYSEAWGYFHLDPAQPRHRMMSAWATC
RLCGLQVGGLPNFQMWTRALCQHLSDVHLPELKKSAAPSSPTTMPCPPPPSPTMAAEGDW
ARLLEQMGELAMRGSQRELELERREAALMQAELELERKRQALKQEAQSVEQERHQLQVER
EALSKWIKKQSPGAQVPEPPSPLPLLPKEDPDIHDNNSDNDMVTKVLL

Sequence of entity 10 (M, P, U, a), FASTA

>9T66_10 NACHT, LRR and PYD domains-containing protein 5 (chains M, P, U, a)
MGPPEKESKAILKARGLEEEQKSERKMTSPENDSKSIQKDQGPEQEQTSESTMGPPEKES
KAILKARGLEEEQKSERKMTSPENDSKSIQKDQGPEQEQTSESTMGPPEKDSKAILKARG
LEEEQKSESTMSPSENVSRAILKDSGSEEVEQASERKMTSPENDSKSIQKDQGPEQEQTS
ETLQSKEEDEVTEADKDNGGDLQDYKAHVIAKFDTSVDLHYDSPEMKLLSDAFKPYQKTF
QPHTIILHGRPGVGKSALARSIVLGWAQGKLFQKMSFVIFFSVREIKWTEKSSLAQLIAK
ECPDSWDLVTKIMSQPERLLFVIDGLDDMDSVLQHDDMTLSRDWKDEQPIYILMYSLLRK
ALLPQSFLIITTRNTGLEKLKSMVVSPLYILVEGLSASRRSQLVLENISNESDRIQVFHS
LIENHQLFDQCQAPSVCSLVCEALQLQKKLGKRCTLPCQTLTGLYATLVFHQLTLKRPSQ
SALSQEEQITLVGLCMMAAEGVWTMRSVFYDDDLKNYSLKESEILALFHMNILLQVGHNS
EQCYVFSHLSLQDFFAALYYVLEGLEEWNQHFCFIENQRSIMEVKRTDDTRLLGMKRFLF
GLMNKDILKTLEVLFEYPVIPTVEQKLQHWVSLIAQQVNGTSPMDTLDAFYCLFESQDEE
FVGGALKRFQEVWLLINQKMDLKVSSYCLKHCQNLKAIRVDIRDLLSVDNTLELCPVVTV
QETQCKPLLMEWWGNFCSVLGSLRNLKELDLGDSILSQRAMKILCLELRNQSCRIQKLTF
KSAEVVSGLKHLWKLLFSNQNLKYLNLGNTPMKDDDMKLACEALKHPKCSVETLRLDSCE
LTIIGYEMISTLLISTTRLKCLSLAKNRVGVKSMISLGNALSSSMCLLQKLILDNCGLTP
ASCHLLVSALFSNQNLTHLCLSNNSLGTEGVQQLCQFLRNPECALQRLILNHCNIVDDAY
GFLAMRLANNTKLTHLSLTMNPVGDGAMKLLCEALKEPTCYLQELELVDCQLTQNCCEDL
ACMITTTKHLKSLDLGNNALGDKGVITLCEGLKQSSSSLRRLGLGACKLTSNCCEALSLA
ISCNPHLNSLNLVKNDFSTSGMLKLCSAFQCPVSNLGIIGLWKQEYYARVRRQLEEVEFV
KPHVVIDGDWYASDEDDRNWWKN

Sequence of entity 11 (N, Q, X, b), FASTA

>9T66_11 Transducin-like enhancer protein 6 (chains N, Q, X, b)
MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIE
RFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQH
PKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQE
HGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPET
QESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVA
VSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFA
GGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQE
IVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTE
DWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMP
TGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY

Primary citation

In-situ cryo-ET of mouse embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies. Singh, K., Harasimov, K., Niakan, K.K. et al. EMBO J (2026). DOI 10.1038/s44318-026-00895-w · PubMed

Other PDB entries of the same protein (UniProt Q8K3V4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

24MC 3.4 Å, Structure of oocyte cytoplasmic lattices
12DL 3.5 Å, Native structure of the cytoplasmic lattice (CPL) asymmetric unit from mouse MII eggs
9XRL 3.74 Å, Structure of mouse cytoplasmic lattice (CPL) repeating unit
9SFP 4.2 Å, Native cytoplasmic lattices from mouse oocytes
9W2M 4.2 Å, Cryo-EM structure of the Cytoplasmic lattice(CPL) from mouse oocyte
9T63 4.7 Å, Asymmetric unit of a cytoplasmic lattice filament repeat unit
9T65 5.6 Å, Complex linking two cytoplasmic lattice filaments
9T64 7.3 Å, Cytoplasmic lattice filament repeat unit with the central FBXW-SKP1 complex
9T67 7.7 Å, Cytoplasmic lattice filament repeat unit with ubiquitin
9T68 8.0 Å, Composite structure of the repeat unit of cytoplasmic lattice filament

Browse structure collections

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