9T8Y: F-box/WD repeat-containing protein 1A

Crystal structure of beta-TrCP bound by monophosphorylated NRF2 degron peptide. Determined by X-ray diffraction at 1.79 Å resolution. Released 8 Apr 2026.

Method: X-ray diffraction
Resolution: 1.79 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,051
Mol. weight: 43.12 kDa
Released: 8 Apr 2026

Explore 9T8Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9T8Y contains 5 α-helices and 28 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	188-199	12
α-helix	201-210	10
α-helix	229-252	24
β-strand	256-261	6	1
β-strand	270-275	6	2
β-strand	279-284	6	2
β-strand	289-293	5	2
β-strand	299-303	5	2
β-strand	310-315	6	3
β-strand	319-324	6	3
β-strand	328-333	6	3
β-strand	339-344	6	3
β-strand	350-356	7	4
β-strand	359-364	6	4
β-strand	369-376	8	4
β-strand	379-386	8	4
β-strand	393-398	6	5
β-strand	402-407	6	5
β-strand	411-416	6	5
β-strand	422-427	6	5
β-strand	433-439	7	6
β-strand	442-447	6	6
β-strand	452-456	5	6
β-strand	461-466	6	6
β-strand	473-478	6	7
β-strand	482-487	6	7
β-strand	491-496	6	7
α-helix	497-501	5
α-helix	507-509	3
β-strand	511-516	6	7
β-strand	522-527	6	1
β-strand	531-536	6	1
β-strand	540-545	6	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
F-box/WD repeat-containing protein 1A	A	protein	365	Homo sapiens	Q9Y297 (AlphaFold model)
Nuclear factor erythroid 2-related factor 2	B	protein	12	Homo sapiens	Q16236 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9T8Y_1 F-box/WD repeat-containing protein 1A (chains A)
GSGMEWKKEIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDI
ETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL
TGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTC
SKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFV
RTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRI
VSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILI
WDFLN

Sequence of entity 2 (B), FASTA

>9T8Y_2 Nuclear factor erythroid 2-related factor 2 (chains B)
NDSDSGISLNTS

Primary citation

Targeting the Interaction of NRF2 and beta-TrCP with Molecular Glues. O Donovan, D.H., Winter-Holt, J., Collie, G.W. et al. ACS Chem Biol (2026) 21:635-642. DOI 10.1021/acschembio.5c01006 · PubMed

Other PDB entries of the same protein (UniProt Q9Y297 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9T9W 1.16 Å, Crystal structure of beta-TrCP bound by diphosphorylated I-kappa-B-alpha degron peptide
9TES 1.22 Å, Crystal structure of beta-TrCP bound by diphosphorylated PDCD4 degron peptide
9TDZ 1.35 Å, Crystal structure of beta-TrCP bound by diphosphorylated claspin degron peptide
9TG7 1.68 Å, Crystal structure of beta-TrCP bound by monophosphorylated WEE1 degron peptide
9TFU 2.0 Å, Crystal structure of beta-TrCP bound by monophosphorylated ATF4 degron peptide
6M90 2.05 Å, Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex
9T95 2.15 Å, Crystal structure of beta-TrCP bound by diphosphorylated NRF2 degron peptide.
6M92 2.35 Å, Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex
6M91 2.4 Å, Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex
2P64 2.5 Å, D domain of b-TrCP
6M93 2.5 Å, Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex
6M94 2.7 Å, Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex

Browse structure collections

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