9TPW: Serine/threonine-protein kinase mTOR
cryo-ET structure of mTOR complex 2 on a PIP2-containing membrane. Determined by electron microscopy at 6.4 Å resolution. Released 22 Apr 2026.
- Method
- Electron microscopy
- Resolution
- 6.4 Å
- Organism
- Homo sapiens
- Chains
- 8
- Atoms
- 61,288
- Mol. weight
- 1168.37 kDa
- Ligands
- ZN
- Released
- 22 Apr 2026
Explore 9TPW in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9TPW contains 496 α-helices and 100 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 153 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34-51 | 18 | |
| α-helix | 57-76 | 20 | |
| α-helix | 80-91 | 12 | |
| β-strand | 94 | 1 | 1 |
| β-strand | 97 | 1 | 1 |
| α-helix | 105-114 | 10 | |
| α-helix | 120-133 | 14 | |
| α-helix | 140-157 | 18 | |
| α-helix | 162-178 | 17 | |
| α-helix | 187-198 | 12 | |
| α-helix | 203-221 | 19 | |
| α-helix | 224-226 | 3 | |
| α-helix | 233-245 | 13 | |
| α-helix | 249-251 | 3 | |
| α-helix | 257-275 | 19 | |
| α-helix | 278-281 | 4 | |
| α-helix | 283-301 | 19 | |
| α-helix | 360-380 | 21 | |
| α-helix | 386-400 | 15 | |
| α-helix | 406-409 | 4 | |
| α-helix | 412-424 | 13 | |
| α-helix | 430-443 | 14 | |
| α-helix | 446-450 | 5 | |
| α-helix | 452-462 | 11 | |
| α-helix | 464-465 | 2 | |
| α-helix | 473 | 1 | |
| α-helix | 475 | 1 | |
| α-helix | 477-479 | 3 | |
| α-helix | 480-510 | 31 | |
| α-helix | 515-527 | 13 | |
| α-helix | 531-546 | 16 | |
| α-helix | 559-563 | 5 | |
| α-helix | 579-589 | 11 | |
| α-helix | 599-608 | 10 | |
| α-helix | 610-612 | 3 | |
| α-helix | 616-628 | 13 | |
| α-helix | 650-665 | 16 | |
| α-helix | 669-678 | 10 | |
| α-helix | 681-683 | 3 | |
| α-helix | 684-687 | 4 | |
| α-helix | 690-699 | 10 | |
| α-helix | 705-718 | 14 | |
| α-helix | 719-721 | 3 | |
| α-helix | 723-743 | 21 | |
| α-helix | 747-763 | 17 | |
| α-helix | 765-768 | 4 | |
| α-helix | 769-771 | 3 | |
| α-helix | 772-783 | 12 | |
| α-helix | 792-808 | 17 | |
| α-helix | 811-813 | 3 | |
| α-helix | 814-824 | 11 | |
| α-helix | 837-851 | 15 | |
| α-helix | 856-860 | 5 | |
| α-helix | 863-874 | 12 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-902 | 7 | |
| α-helix | 931-934 | 4 | |
| α-helix | 943-960 | 18 | |
| α-helix | 962-964 | 3 | |
| α-helix | 968-982 | 15 | |
| α-helix | 983-989 | 7 | |
| α-helix | 990-1003 | 14 | |
| α-helix | 1006-1023 | 18 | |
| α-helix | 1024-1027 | 4 | |
| α-helix | 1031-1041 | 11 | |
| α-helix | 1048-1063 | 16 | |
| α-helix | 1064-1069 | 6 | |
| α-helix | 1071-1084 | 14 | |
| α-helix | 1088-1090 | 3 | |
| α-helix | 1091-1100 | 10 | |
| α-helix | 1104-1109 | 6 | |
| α-helix | 1111-1123 | 13 | |
| α-helix | 1129-1142 | 14 | |
| α-helix | 1149-1151 | 3 | |
| α-helix | 1152-1163 | 12 | |
| α-helix | 1167-1169 | 3 | |
| α-helix | 1170-1184 | 15 | |
| α-helix | 1185-1191 | 7 | |
| α-helix | 1192-1202 | 11 | |
| α-helix | 1207-1218 | 12 | |
| α-helix | 1222-1224 | 3 | |
| α-helix | 1229-1236 | 8 | |
| α-helix | 1262-1269 | 8 | |
| α-helix | 1277-1293 | 17 | |
| α-helix | 1298-1302 | 5 | |
| α-helix | 1304-1309 | 6 | |
| α-helix | 1312-1316 | 5 | |
| α-helix | 1318-1326 | 9 | |
| α-helix | 1331-1347 | 17 | |
| α-helix | 1351-1366 | 16 | |
| α-helix | 1377-1379 | 3 | |
| α-helix | 1380-1389 | 10 | |
| α-helix | 1393-1406 | 14 | |
| α-helix | 1410-1422 | 13 | |
| α-helix | 1426-1439 | 14 | |
| α-helix | 1442-1444 | 3 | |
| α-helix | 1447-1452 | 6 | |
| α-helix | 1456-1469 | 14 | |
| α-helix | 1474-1487 | 14 | |
| α-helix | 1490-1501 | 12 | |
| α-helix | 1506-1522 | 17 | |
| α-helix | 1526-1535 | 10 | |
| α-helix | 1541-1553 | 13 | |
| α-helix | 1557-1570 | 14 | |
| α-helix | 1572-1581 | 10 | |
| α-helix | 1583-1607 | 25 | |
| α-helix | 1609-1611 | 3 | |
| α-helix | 1612-1625 | 14 | |
| α-helix | 1630-1640 | 11 | |
| α-helix | 1646-1648 | 3 | |
| α-helix | 1650-1661 | 12 | |
| α-helix | 1666-1677 | 12 | |
| α-helix | 1688-1690 | 3 | |
| α-helix | 1694-1706 | 13 | |
| α-helix | 1710-1727 | 18 | |
| α-helix | 1739-1762 | 24 | |
| α-helix | 1769-1782 | 14 | |
| α-helix | 1787-1812 | 26 | |
| α-helix | 1874-1893 | 20 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1917-1929 | 13 | |
| α-helix | 1932-1938 | 7 | |
| α-helix | 1939-1943 | 5 | |
| α-helix | 1951-1967 | 17 | |
| α-helix | 1969-1980 | 12 | |
| α-helix | 1985-1998 | 14 | |
| α-helix | 2003-2020 | 18 | |
| α-helix | 2023-2039 | 17 | |
| α-helix | 2044-2059 | 16 | |
| α-helix | 2065-2091 | 27 | |
| α-helix | 2094-2114 | 21 | |
| α-helix | 2115-2117 | 3 | |
| β-strand | 2120-2122 | 3 | 2 |
| α-helix | 2123-2126 | 4 | |
| α-helix | 2128-2131 | 4 | |
| α-helix | 2138 | 1 | |
| β-strand | 2139 | 1 | 3 |
| α-helix | 2140 | 1 | |
| β-strand | 2152 | 1 | 3 |
| β-strand | 2153-2156 | 4 | 2 |
| β-strand | 2159-2162 | 4 | 2 |
| α-helix | 2163 | 1 | |
| α-helix | 2169 | 1 | |
| β-strand | 2170-2176 | 7 | 2 |
| β-strand | 2181-2187 | 7 | 2 |
| α-helix | 2193-2211 | 19 | |
| α-helix | 2213-2217 | 5 | |
| β-strand | 2227-2231 | 5 | 2 |
| β-strand | 2234-2238 | 5 | 2 |
| β-strand | 2243-2245 | 3 | 4 |
| α-helix | 2246-2256 | 11 | |
| α-helix | 2263-2271 | 9 | |
| α-helix | 2275-2277 | 3 | |
| α-helix | 2280-2292 | 13 | |
| α-helix | 2298-2305 | 8 | |
| α-helix | 2310-2334 | 25 | |
| β-strand | 2344-2347 | 4 | 4 |
| β-strand | 2353-2355 | 3 | 4 |
| α-helix | 2364-2367 | 4 | |
| α-helix | 2381-2387 | 7 | |
| α-helix | 2395-2409 | 15 | |
| α-helix | 2411-2422 | 12 | |
| α-helix | 2428-2430 | 3 | |
| α-helix | 2495-2507 | 13 | |
| α-helix | 2521-2533 | 13 | |
| α-helix | 2535-2539 | 5 | |
| α-helix | 2543-2545 | 3 | |
Chain B: 156 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34-38 | 5 | |
| α-helix | 42-49 | 8 | |
| α-helix | 51-54 | 4 | |
| α-helix | 57-76 | 20 | |
| α-helix | 82-92 | 11 | |
| α-helix | 101-114 | 14 | |
| α-helix | 120-133 | 14 | |
| α-helix | 140-157 | 18 | |
| α-helix | 162-178 | 17 | |
| α-helix | 181-184 | 4 | |
| α-helix | 187-191 | 5 | |
| α-helix | 194-198 | 5 | |
| α-helix | 203-221 | 19 | |
| α-helix | 224-226 | 3 | |
| α-helix | 232-245 | 14 | |
| α-helix | 247-249 | 3 | |
| α-helix | 257-274 | 18 | |
| α-helix | 277-303 | 27 | |
| α-helix | 360-380 | 21 | |
| α-helix | 386-402 | 17 | |
| α-helix | 406-409 | 4 | |
| α-helix | 411-425 | 15 | |
| α-helix | 430-443 | 14 | |
| α-helix | 446-449 | 4 | |
| α-helix | 452-462 | 11 | |
| α-helix | 464-465 | 2 | |
| α-helix | 474-477 | 4 | |
| α-helix | 480-493 | 14 | |
| α-helix | 494-497 | 4 | |
| α-helix | 499-511 | 13 | |
| α-helix | 515-527 | 13 | |
| α-helix | 529-531 | 3 | |
| α-helix | 532-547 | 16 | |
| α-helix | 552-554 | 3 | |
| α-helix | 561-564 | 4 | |
| α-helix | 568-572 | 5 | |
| α-helix | 579-591 | 13 | |
| α-helix | 599-610 | 12 | |
| α-helix | 616-629 | 14 | |
| α-helix | 650-665 | 16 | |
| α-helix | 669-678 | 10 | |
| α-helix | 681-683 | 3 | |
| α-helix | 684-687 | 4 | |
| α-helix | 690-699 | 10 | |
| α-helix | 705-718 | 14 | |
| α-helix | 719-721 | 3 | |
| α-helix | 723-743 | 21 | |
| α-helix | 747-756 | 10 | |
| α-helix | 760-763 | 4 | |
| α-helix | 765-768 | 4 | |
| α-helix | 769-771 | 3 | |
| α-helix | 772-783 | 12 | |
| α-helix | 794-809 | 16 | |
| α-helix | 810-813 | 4 | |
| α-helix | 814-824 | 11 | |
| α-helix | 837-851 | 15 | |
| α-helix | 856-860 | 5 | |
| α-helix | 864-872 | 9 | |
| α-helix | 878-891 | 14 | |
| β-strand | 894 | 1 | 5 |
| α-helix | 896-901 | 6 | |
| α-helix | 931-934 | 4 | |
| α-helix | 943-959 | 17 | |
| α-helix | 962-964 | 3 | |
| α-helix | 965-982 | 18 | |
| α-helix | 983-989 | 7 | |
| α-helix | 990-1003 | 14 | |
| α-helix | 1006-1023 | 18 | |
| α-helix | 1024-1030 | 7 | |
| α-helix | 1031-1041 | 11 | |
| α-helix | 1048-1063 | 16 | |
| α-helix | 1064-1069 | 6 | |
| α-helix | 1071-1084 | 14 | |
| α-helix | 1088-1090 | 3 | |
| α-helix | 1091-1100 | 10 | |
| α-helix | 1104-1110 | 7 | |
| α-helix | 1111-1123 | 13 | |
| α-helix | 1129-1142 | 14 | |
| α-helix | 1149-1151 | 3 | |
| α-helix | 1152-1165 | 14 | |
| α-helix | 1170-1184 | 15 | |
| α-helix | 1185-1191 | 7 | |
| α-helix | 1192-1202 | 11 | |
| α-helix | 1207-1218 | 12 | |
| α-helix | 1222-1224 | 3 | |
| α-helix | 1229-1237 | 9 | |
| α-helix | 1261-1264 | 4 | |
| α-helix | 1266-1269 | 4 | |
| α-helix | 1277-1294 | 18 | |
| α-helix | 1298-1309 | 12 | |
| α-helix | 1312-1316 | 5 | |
| α-helix | 1318-1326 | 9 | |
| α-helix | 1331-1346 | 16 | |
| α-helix | 1351-1366 | 16 | |
| α-helix | 1376-1379 | 4 | |
| α-helix | 1380-1389 | 10 | |
| α-helix | 1393-1406 | 14 | |
| α-helix | 1410-1422 | 13 | |
| α-helix | 1426-1439 | 14 | |
| α-helix | 1442-1444 | 3 | |
| α-helix | 1447-1452 | 6 | |
| α-helix | 1456-1469 | 14 | |
| α-helix | 1474-1487 | 14 | |
| α-helix | 1490-1499 | 10 | |
| α-helix | 1506-1523 | 18 | |
| α-helix | 1526-1535 | 10 | |
| α-helix | 1541-1553 | 13 | |
| α-helix | 1557-1581 | 25 | |
| α-helix | 1583-1607 | 25 | |
| α-helix | 1609-1611 | 3 | |
| α-helix | 1612-1625 | 14 | |
| β-strand | 1626 | 1 | 5 |
| α-helix | 1630-1640 | 11 | |
| α-helix | 1646-1648 | 3 | |
| α-helix | 1650-1661 | 12 | |
| β-strand | 1662 | 1 | 6 |
| β-strand | 1664 | 1 | 6 |
| α-helix | 1666-1677 | 12 | |
| α-helix | 1688-1690 | 3 | |
| α-helix | 1694-1706 | 13 | |
| α-helix | 1710-1727 | 18 | |
| α-helix | 1739-1762 | 24 | |
| α-helix | 1769-1782 | 14 | |
| α-helix | 1787-1812 | 26 | |
| α-helix | 1874-1894 | 21 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1917-1929 | 13 | |
| α-helix | 1932-1938 | 7 | |
| α-helix | 1939-1944 | 6 | |
| α-helix | 1951-1967 | 17 | |
| α-helix | 1969-1980 | 12 | |
| α-helix | 1985-1998 | 14 | |
| α-helix | 2003-2020 | 18 | |
| α-helix | 2023-2036 | 14 | |
| α-helix | 2037-2041 | 5 | |
| α-helix | 2044-2059 | 16 | |
| α-helix | 2065-2091 | 27 | |
| α-helix | 2094-2114 | 21 | |
| α-helix | 2115-2117 | 3 | |
| β-strand | 2120-2122 | 3 | 7 |
| α-helix | 2123-2126 | 4 | |
| α-helix | 2128-2132 | 5 | |
| β-strand | 2139 | 1 | 8 |
| α-helix | 2140 | 1 | |
| β-strand | 2152 | 1 | 8 |
| β-strand | 2153-2156 | 4 | 7 |
| β-strand | 2159-2162 | 4 | 7 |
| α-helix | 2169 | 1 | |
| β-strand | 2170-2176 | 7 | 7 |
| β-strand | 2181-2187 | 7 | 7 |
| α-helix | 2193-2211 | 19 | |
| α-helix | 2213-2217 | 5 | |
| β-strand | 2227-2231 | 5 | 7 |
| β-strand | 2234-2238 | 5 | 7 |
| β-strand | 2243-2245 | 3 | 9 |
| α-helix | 2246-2256 | 11 | |
| α-helix | 2263-2271 | 9 | |
| α-helix | 2275-2277 | 3 | |
| α-helix | 2280-2292 | 13 | |
| α-helix | 2298-2305 | 8 | |
| α-helix | 2310-2334 | 25 | |
| β-strand | 2344-2347 | 4 | 9 |
| β-strand | 2353-2355 | 3 | 9 |
| α-helix | 2364-2367 | 4 | |
| α-helix | 2381-2386 | 6 | |
| α-helix | 2395-2409 | 15 | |
| α-helix | 2411-2422 | 12 | |
| α-helix | 2425-2428 | 4 | |
| α-helix | 2495-2508 | 14 | |
| α-helix | 2521-2533 | 13 | |
| α-helix | 2535-2538 | 4 | |
| α-helix | 2543-2545 | 3 | |
Chain C: 2 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-19 | 6 | 10 |
| β-strand | 23-28 | 6 | 10 |
| β-strand | 33-39 | 7 | 10 |
| β-strand | 47-50 | 4 | 11 |
| β-strand | 56-60 | 5 | 11 |
| β-strand | 65-69 | 5 | 11 |
| β-strand | 79-82 | 4 | 11 |
| β-strand | 88-93 | 6 | 12 |
| β-strand | 100-104 | 5 | 12 |
| β-strand | 108-112 | 5 | 12 |
| β-strand | 123-126 | 4 | 12 |
| β-strand | 131-136 | 6 | 13 |
| β-strand | 142-147 | 6 | 13 |
| β-strand | 152-156 | 5 | 13 |
| β-strand | 162-165 | 4 | 13 |
| β-strand | 173-178 | 6 | 14 |
| β-strand | 184-189 | 6 | 14 |
| α-helix | 190-192 | 3 | |
| β-strand | 194-199 | 6 | 14 |
| β-strand | 210-216 | 7 | 14 |
| β-strand | 223-228 | 6 | 15 |
| β-strand | 234-239 | 6 | 15 |
| β-strand | 243-248 | 6 | 15 |
| β-strand | 254-259 | 6 | 15 |
| α-helix | 265-267 | 3 | |
| β-strand | 273-278 | 6 | 16 |
| β-strand | 284-289 | 6 | 16 |
| β-strand | 294-298 | 5 | 16 |
| β-strand | 304-308 | 5 | 16 |
| β-strand | 315-321 | 7 | 10 |
Chain D: 1 helix, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-19 | 6 | 17 |
| β-strand | 23-27 | 5 | 17 |
| β-strand | 34-39 | 6 | 17 |
| β-strand | 45-50 | 6 | 18 |
| β-strand | 56-61 | 6 | 18 |
| β-strand | 65-69 | 5 | 18 |
| β-strand | 79-82 | 4 | 18 |
| β-strand | 88-93 | 6 | 19 |
| β-strand | 99-104 | 6 | 19 |
| β-strand | 108-113 | 6 | 19 |
| β-strand | 123-126 | 4 | 19 |
| β-strand | 131-136 | 6 | 20 |
| β-strand | 142-147 | 6 | 20 |
| β-strand | 152-156 | 5 | 20 |
| β-strand | 162-165 | 4 | 20 |
| β-strand | 173-178 | 6 | 21 |
| β-strand | 184-189 | 6 | 21 |
| β-strand | 194-199 | 6 | 21 |
| β-strand | 210-216 | 7 | 21 |
| β-strand | 223-228 | 6 | 22 |
| β-strand | 234-239 | 6 | 22 |
| β-strand | 243-248 | 6 | 22 |
| β-strand | 254-259 | 6 | 22 |
| α-helix | 265-267 | 3 | |
| β-strand | 273-278 | 6 | 23 |
| β-strand | 284-289 | 6 | 23 |
| β-strand | 293-298 | 6 | 23 |
| β-strand | 304-308 | 5 | 23 |
| β-strand | 315-321 | 7 | 17 |
Chain E: 86 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34-46 | 13 | |
| α-helix | 53-70 | 18 | |
| α-helix | 74-77 | 4 | |
| α-helix | 81-91 | 11 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-121 | 8 | |
| α-helix | 122-124 | 3 | |
| α-helix | 125-134 | 10 | |
| α-helix | 140-157 | 18 | |
| α-helix | 158-160 | 3 | |
| α-helix | 163-175 | 13 | |
| α-helix | 184-195 | 12 | |
| α-helix | 199-204 | 6 | |
| α-helix | 207-217 | 11 | |
| α-helix | 221-236 | 16 | |
| α-helix | 238-241 | 4 | |
| α-helix | 250-254 | 5 | |
| α-helix | 255-258 | 4 | |
| α-helix | 270-272 | 3 | |
| α-helix | 273-292 | 20 | |
| α-helix | 295-301 | 7 | |
| α-helix | 308-316 | 9 | |
| α-helix | 321-334 | 14 | |
| α-helix | 338-341 | 4 | |
| α-helix | 346-352 | 7 | |
| α-helix | 360-362 | 3 | |
| α-helix | 368-376 | 9 | |
| α-helix | 378-379 | 2 | |
| β-strand | 386 | 1 | 24 |
| α-helix | 387-401 | 15 | |
| α-helix | 404-413 | 10 | |
| α-helix | 417-437 | 21 | |
| α-helix | 440-443 | 4 | |
| α-helix | 446-448 | 3 | |
| α-helix | 450-457 | 8 | |
| α-helix | 463-485 | 23 | |
| α-helix | 492-506 | 15 | |
| α-helix | 525-534 | 10 | |
| α-helix | 543-545 | 3 | |
| α-helix | 548-556 | 9 | |
| α-helix | 568-581 | 14 | |
| α-helix | 583-585 | 3 | |
| α-helix | 588-590 | 3 | |
| β-strand | 592 | 1 | 25 |
| α-helix | 598-614 | 17 | |
| α-helix | 617-637 | 21 | |
| α-helix | 651-653 | 3 | |
| β-strand | 654 | 1 | 25 |
| α-helix | 655-658 | 4 | |
| α-helix | 659-667 | 9 | |
| α-helix | 670-678 | 9 | |
| α-helix | 681-688 | 8 | |
| α-helix | 695-704 | 10 | |
| α-helix | 712-723 | 12 | |
| α-helix | 726-741 | 16 | |
| α-helix | 747-749 | 3 | |
| α-helix | 751-757 | 7 | |
| α-helix | 758-760 | 3 | |
| α-helix | 764-777 | 14 | |
| α-helix | 781-790 | 10 | |
| α-helix | 795-797 | 3 | |
| α-helix | 799-805 | 7 | |
| α-helix | 806-810 | 5 | |
| α-helix | 812-819 | 8 | |
| α-helix | 823-830 | 8 | |
| α-helix | 831-835 | 5 | |
| α-helix | 836-851 | 16 | |
| β-strand | 877 | 1 | 24 |
| α-helix | 878-880 | 3 | |
| α-helix | 882-886 | 5 | |
| α-helix | 890-898 | 9 | |
| α-helix | 901-910 | 10 | |
| α-helix | 917-933 | 17 | |
| α-helix | 937-946 | 10 | |
| α-helix | 949-958 | 10 | |
| α-helix | 962-975 | 14 | |
| α-helix | 979-986 | 8 | |
| β-strand | 990-992 | 3 | 26 |
| α-helix | 1002-1005 | 4 | |
| β-strand | 1428-1430 | 3 | 26 |
| α-helix | 1433-1436 | 4 | |
| α-helix | 1445-1447 | 3 | |
| α-helix | 1481-1486 | 6 | |
| α-helix | 1489-1494 | 6 | |
| α-helix | 1525-1528 | 4 | |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1607-1623 | 17 | |
| α-helix | 1629-1642 | 14 | |
| α-helix | 1644-1647 | 4 | |
| α-helix | 1650-1659 | 10 | |
| α-helix | 1667-1676 | 10 | |
| α-helix | 1683-1692 | 10 | |
Chain F: 84 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34-46 | 13 | |
| α-helix | 53-70 | 18 | |
| α-helix | 74-77 | 4 | |
| α-helix | 81-91 | 11 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-121 | 8 | |
| α-helix | 122-124 | 3 | |
| α-helix | 126-134 | 9 | |
| α-helix | 140-157 | 18 | |
| α-helix | 158-160 | 3 | |
| α-helix | 163-175 | 13 | |
| α-helix | 184-195 | 12 | |
| α-helix | 199-204 | 6 | |
| α-helix | 207-217 | 11 | |
| α-helix | 221-236 | 16 | |
| α-helix | 238-241 | 4 | |
| α-helix | 246-248 | 3 | |
| α-helix | 250-254 | 5 | |
| α-helix | 255-258 | 4 | |
| α-helix | 273-292 | 20 | |
| α-helix | 295-301 | 7 | |
| α-helix | 308-317 | 10 | |
| α-helix | 321-334 | 14 | |
| α-helix | 337-341 | 5 | |
| α-helix | 346-352 | 7 | |
| α-helix | 360-362 | 3 | |
| α-helix | 368-376 | 9 | |
| α-helix | 378-379 | 2 | |
| β-strand | 386 | 1 | 27 |
| α-helix | 387-401 | 15 | |
| α-helix | 404-413 | 10 | |
| α-helix | 417-437 | 21 | |
| α-helix | 440-443 | 4 | |
| α-helix | 446-448 | 3 | |
| α-helix | 450-457 | 8 | |
| α-helix | 463-485 | 23 | |
| α-helix | 492-506 | 15 | |
| α-helix | 525-534 | 10 | |
| α-helix | 548-556 | 9 | |
| α-helix | 562-565 | 4 | |
| α-helix | 568-581 | 14 | |
| α-helix | 583-585 | 3 | |
| α-helix | 588-590 | 3 | |
| β-strand | 592 | 1 | 28 |
| α-helix | 598-613 | 16 | |
| α-helix | 616-638 | 23 | |
| α-helix | 650-652 | 3 | |
| β-strand | 654 | 1 | 28 |
| α-helix | 655-658 | 4 | |
| α-helix | 659-667 | 9 | |
| α-helix | 670-678 | 9 | |
| α-helix | 681-688 | 8 | |
| α-helix | 695-704 | 10 | |
| α-helix | 712-723 | 12 | |
| α-helix | 726-741 | 16 | |
| α-helix | 747-749 | 3 | |
| α-helix | 751-758 | 8 | |
| α-helix | 764-777 | 14 | |
| α-helix | 781-790 | 10 | |
| α-helix | 795-797 | 3 | |
| α-helix | 799-805 | 7 | |
| α-helix | 806-810 | 5 | |
| α-helix | 812-821 | 10 | |
| α-helix | 823-833 | 11 | |
| α-helix | 836-851 | 16 | |
| β-strand | 877 | 1 | 27 |
| α-helix | 878-880 | 3 | |
| α-helix | 882-886 | 5 | |
| α-helix | 890-898 | 9 | |
| α-helix | 901-909 | 9 | |
| α-helix | 917-933 | 17 | |
| α-helix | 937-946 | 10 | |
| α-helix | 949-958 | 10 | |
| α-helix | 962-975 | 14 | |
| α-helix | 979-986 | 8 | |
| β-strand | 990-992 | 3 | 29 |
| α-helix | 1002-1005 | 4 | |
| β-strand | 1428-1430 | 3 | 29 |
| α-helix | 1433-1437 | 5 | |
| α-helix | 1445-1447 | 3 | |
| α-helix | 1481-1484 | 4 | |
| α-helix | 1489-1493 | 5 | |
| α-helix | 1521-1529 | 9 | |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1607-1623 | 17 | |
| α-helix | 1629-1642 | 14 | |
| α-helix | 1644-1647 | 4 | |
| α-helix | 1650-1659 | 10 | |
| α-helix | 1667-1676 | 10 | |
| α-helix | 1683-1693 | 11 | |
Chain G: 7 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-21 | 15 | |
| α-helix | 26-30 | 5 | |
| α-helix | 33-36 | 4 | |
| α-helix | 85-98 | 14 | |
| β-strand | 104-107 | 4 | 11 |
| α-helix | 120-122 | 3 | |
| α-helix | 132-134 | 3 | |
| α-helix | 139-141 | 3 | |
Chain H: 7 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-21 | 15 | |
| α-helix | 26-30 | 5 | |
| α-helix | 34-36 | 3 | |
| α-helix | 85-98 | 14 | |
| β-strand | 104-107 | 4 | 18 |
| α-helix | 120-122 | 3 | |
| α-helix | 132-134 | 3 | |
| α-helix | 139-141 | 3 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Serine/threonine-protein kinase mTOR | A, B | protein | 2590 | Homo sapiens | P42345 (AlphaFold model) |
| Target of rapamycin complex subunit LST8 | C, D | protein | 326 | Homo sapiens | Q9BVC4 (AlphaFold model) |
| Rapamycin-insensitive companion of mTOR | E, F | protein | 1734 | Homo sapiens | Q6R327 (AlphaFold model) |
| Target of rapamycin complex 2 subunit MAPKAP1 | G, H | protein | 522 | Homo sapiens | Q9BPZ7 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>9TPW_1 Serine/threonine-protein kinase mTOR (chains A, B)
MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGENLYFQGGTMLGTGPAAATTAATTSSNV
SVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSD
ANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDT
FTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVW
DPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDD
RIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSF
QAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLK
CRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGL
LSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQ
DIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPK
GLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIR
MEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASL
DERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILT
ELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVL
ATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYR
KYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSE
SKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIF
KSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMR
EFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAA
IQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPI
VRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKG
YTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDD
WLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIR
SIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHY
KELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDA
LVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAA
AWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMA
GESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMV
RSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYA
YMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQL
NLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRH
ASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLM
YTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVI
PQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMC
EHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMME
RGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLT
SLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNG
HEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGW
VPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDL
AKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG
DCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLE
AFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESI
HSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLC
QCYIGWCPFW
Sequence of entity 2 (C, D), FASTA
>9TPW_2 Target of rapamycin complex subunit LST8 (chains C, D)
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
Sequence of entity 3 (E, F), FASTA
>9TPW_3 Rapamycin-insensitive companion of mTOR (chains E, F)
MADYKDHDGDYKDHDIDYKDDDDKGTMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREP
SDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLN
EAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMI
TVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKN
VIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLK
EDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDI
FRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLAL
ILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMN
MAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRV
QKDIFILKDTEEALLINLRDSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFV
RRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWL
NASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQ
DHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIEL
LVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKG
FSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRP
HVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIG
SSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVR
HSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGS
SSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSD
PKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGS
TPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSS
SPSRETVGVDATTMDTDCGSMSTVVSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSH
TLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASP
AKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVS
SATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGG
LVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPS
NQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTEL
LLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYS
EVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLATPPKQPIVDTSAES
Sequence of entity 4 (G, H), FASTA
>9TPW_4 Target of rapamycin complex 2 subunit MAPKAP1 (chains G, H)
XAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 2 |
Primary citation
Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop. Hay, I.M., Bourguet, M., Ahsan, B. et al. bioRxiv (2026). DOI 10.64898/2026.01.08.698367
Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
- 9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
- 5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
- 5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
- 4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
- 3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
- 8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
- 8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
- 9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
- 9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
- 9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
- 9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR
Browse structure collections
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