Cryo-EM structure of DICER/26S-UG complex in dicing state. Determined by electron microscopy at 3.34 Å resolution. Released 11 Mar 2026.
Explore 9V43 in 3D Show helices and sheets RCSB PDB PDBe
9V43 contains 28 α-helices and 15 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 750-752 | 3 | |
| β-strand | 769-770 | 2 | 1 |
| β-strand | 773-776 | 4 | 2 |
| α-helix | 792-794 | 3 | |
| α-helix | 795-797 | 3 | |
| β-strand | 801-806 | 6 | 1 |
| β-strand | 816-821 | 6 | 2 |
| β-strand | 823-829 | 7 | 2 |
| β-strand | 833 | 1 | 1 |
| α-helix | 840-854 | 15 | |
| β-strand | 877-881 | 5 | 1 |
| β-strand | 882-883 | 2 | 3 |
| β-strand | 890-891 | 2 | 3 |
| α-helix | 896-903 | 8 | |
| β-strand | 946 | 1 | 4 |
| α-helix | 970-975 | 6 | |
| α-helix | 986-987 | 2 | |
| β-strand | 991 | 1 | 4 |
| α-helix | 1018-1028 | 11 | |
| α-helix | 1035-1037 | 3 | |
| α-helix | 1045-1073 | 29 | |
| α-helix | 1294-1301 | 8 | |
| α-helix | 1315-1334 | 20 | |
| α-helix | 1340-1363 | 24 | |
| α-helix | 1365-1368 | 4 | |
| α-helix | 1376-1379 | 4 | |
| α-helix | 1556-1585 | 30 | |
| α-helix | 1663-1673 | 11 | |
| α-helix | 1681-1687 | 7 | |
| β-strand | 1688 | 1 | 5 |
| α-helix | 1702-1722 | 21 | |
| α-helix | 1729-1740 | 12 | |
| α-helix | 1742-1751 | 10 | |
| α-helix | 1755-1757 | 3 | |
| β-strand | 1759 | 1 | 5 |
| α-helix | 1763-1775 | 13 | |
| α-helix | 1806-1822 | 17 | |
| α-helix | 1828-1834 | 7 | |
| α-helix | 1839-1847 | 9 | |
| α-helix | 1853-1860 | 8 | |
| β-strand | 1884 | 1 | 6 |
| β-strand | 1888 | 1 | 6 |
| α-helix | 1898-1911 | 14 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| RNA (64-mer) | A | RNA | 64 | synthetic construct | |
| Endoribonuclease Dicer | B | protein | 1909 | Homo sapiens | Q9UPY3 (AlphaFold model) |
>9V43_1 RNA (64-MER) (chains A) UGGAUAUUUCUCGCAGAUCUCAUGUGAAAAAAAAAACACAUGACAUCUGUGAGAAAUAUU CGUA
>9V43_2 Endoribonuclease Dicer (chains B) MGHHHHHHHHHHPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFI AVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASW TKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLC ENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEI VVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVL GPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFV TPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETN FPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQ MEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRA RAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIDPVMDDDDVFPP YVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINS PLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEE TSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRRRKLY PPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYI FSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTK YTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYK TKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQIL VPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPADFRYPN LDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGANRTSSLENHDQMSVNC RTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGNQLNYYKQEIPVQP TTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAVMPGTTDTIQVLKG RMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFC TYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSN TDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFI DNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLD PSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTS CGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSV LKDSEYGCLKIPPRCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYH YNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYD YHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFE SLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERT YDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 2 |
DICER cleavage fidelity is governed by 5'-end binding pockets. Ngo, M.K., Le, C.T., Nguyen, T.A. Nature (2026) 653:611-620. DOI 10.1038/s41586-026-10211-5 · PubMed
Other PDB entries of the same protein (UniProt Q9UPY3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 9V43 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.