9WMW: DNA-directed RNA polymerase subunit

Name: PDB 9WMW: Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp115, FACT-hexamer)
Published: 2025-12-24
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp115, FACT-hexamer). Determined by electron microscopy at 3.62 Å resolution. Released 24 Dec 2025.

Method: Electron microscopy
Resolution: 3.62 Å
Organisms: Komagataella phaffii GS115, synthetic construct, Homo sapiens
Chains: 34
Atoms: 78,756
Mol. weight: 1653.58 kDa
Ligands: MG, ZN
Released: 24 Dec 2025

Explore 9WMW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WMW contains 470 α-helices and 431 β-strands across 31 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	66-75	10
β-strand	83-84	2	29
α-helix	88-113	26
β-strand	118-119	2	30
α-helix	121-131	11

Chain A: 85 helices, 67 β-strands

Element	Residues	Length	Sheet
α-helix	10	1
β-strand	11	1	1
β-strand	16-18	3	2
β-strand	21	1	3
α-helix	22-23	2
α-helix	24-30	7
β-strand	34	1	4
β-strand	37	1	5
α-helix	48-49	2
β-strand	52	1	5
β-strand	82-91	10	4
α-helix	93-95	3
α-helix	96-105	10
β-strand	106	1	6
β-strand	113	1	6
α-helix	120-127	8
α-helix	131-142	12
β-strand	147	1	7
α-helix	170	1
β-strand	171	1	7
α-helix	172-173	2
β-strand	174-178	5	8
β-strand	181-186	6	8
β-strand	199-202	4	8
α-helix	205-213	9
α-helix	217-222	6
α-helix	232-235	4
β-strand	236-242	7	4
β-strand	251-252	2	9
β-strand	258-259	2	9
α-helix	260-261	2
α-helix	262-283	22
α-helix	287-305	19
α-helix	313-315	3
β-strand	316	1	10
α-helix	321	1
β-strand	322	1	10
α-helix	323	1
α-helix	327-329	3
α-helix	336	1
α-helix	337-341	5
β-strand	344-346	3	11
β-strand	349-356	8	12
β-strand	364-368	5	12
α-helix	369-374	6
β-strand	376-380	5	13
α-helix	381	1
α-helix	386-395	10
β-strand	403-407	5	13
β-strand	413-415	3	13
α-helix	422-424	3
α-helix	425-427	3
β-strand	432-436	5	13
α-helix	437	1
β-strand	442-446	5	12
α-helix	453-455	3
β-strand	456-464	9	12
β-strand	469-471	3	12
α-helix	473-475	3
α-helix	476-479	4
β-strand	487-491	5	12
α-helix	496-505	10
β-strand	507	1	12
α-helix	508-511	4
β-strand	513-514	2	14
β-strand	519-520	2	14
α-helix	526-535	10
β-strand	541-542	2	15
α-helix	544-553	10
α-helix	561-564	4
β-strand	566-568	3	16
β-strand	572	1	16
β-strand	573-574	2	15
α-helix	575-582	8
α-helix	584	1
β-strand	589-591	3	17
β-strand	606-609	4	17
β-strand	612-615	4	17
α-helix	620-623	4
α-helix	630-638	9
α-helix	640-661	22
α-helix	667-670	4
α-helix	674-698	25
α-helix	703-706	4
α-helix	711-737	27
α-helix	743-750	8
α-helix	756-763	8
β-strand	767-768	2	18
β-strand	771	1	19
β-strand	774	1	19
α-helix	776-777	2
α-helix	796-798	3
β-strand	800-801	2	18
α-helix	811-846	36
β-strand	850-851	2	20
β-strand	857-858	2	20
β-strand	864-866	3	20
α-helix	869-871	3
β-strand	874	1	21
β-strand	880-883	4	22
α-helix	891-898	8
α-helix	905-907	3
β-strand	914	1	23
α-helix	918-920	3
α-helix	925-943	19
α-helix	944-948	5
β-strand	955-958	4	22
α-helix	962-973	12
α-helix	979-980	2
β-strand	981	1	23
α-helix	985-995	11
α-helix	1007-1016	10
α-helix	1018-1027	10
α-helix	1030-1031	2
α-helix	1032-1037	6
α-helix	1041-1057	17
β-strand	1059	1	21
α-helix	1060-1061	2
α-helix	1066-1079	14
α-helix	1099-1108	10
β-strand	1118-1121	4	24
β-strand	1122	1	25
α-helix	1123	1
α-helix	1124-1127	4
α-helix	1130-1140	11
β-strand	1143-1144	2	26
α-helix	1145-1148	4
β-strand	1149-1156	8	27
α-helix	1169-1176	8
β-strand	1193-1199	7	27
α-helix	1201-1206	6
α-helix	1211-1222	12
β-strand	1226-1230	5	27
β-strand	1239-1244	6	27
α-helix	1260-1273	14
β-strand	1275-1277	3	26
β-strand	1284-1295	12	24
β-strand	1301-1312	12	24
α-helix	1316-1320	5
β-strand	1325	1	25
β-strand	1331-1332	2	24
α-helix	1335-1341	7
α-helix	1344-1360	17
α-helix	1368-1379	12
α-helix	1389-1392	4
α-helix	1399-1403	5
α-helix	1408-1418	11
β-strand	1421-1422	2	2
α-helix	1427-1432	6
α-helix	1440-1442	3
β-strand	1444-1448	5	28
α-helix	1450-1453	4

Chain b: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	26-28	3
α-helix	31-40	10
β-strand	45-46	2	30
α-helix	50-75	26
β-strand	80-81	2	29
α-helix	83-92	10
β-strand	96-98	3	53

Chain B: 52 helices, 74 β-strands

Element	Residues	Length	Sheet
α-helix	14-27	14
α-helix	32-40	9
α-helix	41-45	5
α-helix	46-50	5
β-strand	55-62	8	31
β-strand	71-84	14	31
β-strand	88-90	3	32
β-strand	96-98	3	32
α-helix	101-106	6
β-strand	112-126	15	31
β-strand	155-162	8	31
α-helix	163-164	2
α-helix	177-182	6
β-strand	194-196	3	33
β-strand	199-203	5	33
α-helix	204	1
β-strand	205-209	5	34
α-helix	210	1
β-strand	214-218	5	35
β-strand	227-235	9	35
β-strand	240-249	10	35
β-strand	261-263	3	35
β-strand	272-273	2	35
α-helix	274-281	8
α-helix	286-293	8
α-helix	300-313	14
α-helix	319-328	10
α-helix	338-350	13
α-helix	365-382	18
α-helix	387-389	3
α-helix	394-396	3
β-strand	397-400	4	34
α-helix	402-431	30
α-helix	443-456	14
β-strand	473-475	3	33
α-helix	476-477	2
α-helix	481-488	8
β-strand	490-492	3	34
α-helix	502-505	4
α-helix	509-511	3
β-strand	515	1	36
β-strand	529-531	3	34
β-strand	532	1	36
β-strand	537-538	2	37
α-helix	545-553	9
β-strand	557-558	2	38
α-helix	559-561	3
α-helix	570	1
β-strand	571-575	5	38
β-strand	578-583	6	38
α-helix	586-598	13
β-strand	607-611	5	38
β-strand	616-620	5	38
β-strand	626-632	7	37
β-strand	633	1	39
β-strand	645	1	39
α-helix	649-657	9
α-helix	678-683	6
β-strand	687-691	5	37
α-helix	694-697	4
β-strand	700-701	2	37
α-helix	704-707	4
β-strand	740-741	2	37
α-helix	745-748	4
α-helix	752-754	3
α-helix	759-761	3
α-helix	764-773	10
α-helix	774-776	3
β-strand	777	1	40
β-strand	792-796	5	41
β-strand	800	1	42
β-strand	804-805	2	43
α-helix	807-810	4
β-strand	821-827	7	44
β-strand	838-842	5	44
α-helix	843-848	6
β-strand	853-862	10	41
β-strand	865	1	45
β-strand	871	1	45
β-strand	873-874	2	46
β-strand	882-883	2	46
β-strand	898	1	47
α-helix	899-900	2
β-strand	904-905	2	41
β-strand	910-912	3	47
β-strand	914-917	4	46
α-helix	922-925	4
β-strand	927	1	48
β-strand	934-936	3	46
β-strand	939-940	2	47
α-helix	941-942	2
β-strand	947-956	10	41
β-strand	962-972	11	41
β-strand	979-982	4	44
β-strand	987-994	8	44
α-helix	996-998	3
β-strand	1001-1002	2	49
β-strand	1010-1012	3	44
α-helix	1014-1016	3
α-helix	1017-1020	4
α-helix	1023-1038	16
β-strand	1041-1043	3	43
α-helix	1052-1061	10
β-strand	1069-1070	2	44
β-strand	1072-1073	2	49
α-helix	1079	1
β-strand	1080	1	49
α-helix	1081	1
β-strand	1085-1094	10	44
β-strand	1095	1	40
α-helix	1099-1101	3
β-strand	1104-1106	3	12
β-strand	1111	1	50
β-strand	1118	1	50
β-strand	1128-1130	3	11
α-helix	1132-1141	10
α-helix	1144-1152	9
β-strand	1157-1163	7	1
β-strand	1174	1	51
β-strand	1179	1	51
β-strand	1182	1	52
β-strand	1187	1	52
β-strand	1191-1197	7	1
α-helix	1198-1209	12
β-strand	1212	1	3
β-strand	1215-1217	3	2

Chain C: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	6-12	7	54
β-strand	16-22	7	54
α-helix	26-38	13
β-strand	42-53	12	55
α-helix	59-67	9
β-strand	71-73	3	56
α-helix	82-84	3
β-strand	96-103	8	55
β-strand	111-114	4	57
α-helix	115-117	3
β-strand	119-122	4	55
β-strand	129-132	4	56
α-helix	133	1
β-strand	143-147	5	57
β-strand	152-162	11	55
α-helix	168-170	3
β-strand	173-180	8	54
α-helix	197-200	4
α-helix	202-204	3
α-helix	207-209	3
α-helix	211-214	4
β-strand	227-234	8	54
α-helix	240-265	26

Chain D: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	28
β-strand	24	1	60
β-strand	29	1	60
β-strand	37-39	3	61
β-strand	45-47	3	61
β-strand	49-51	3	28
α-helix	53-71	19
α-helix	86-92	7
α-helix	96-111	16
α-helix	118-130	13
α-helix	133-135	3
α-helix	139-148	10
α-helix	153-159	7
α-helix	161-164	4
α-helix	171-181	11

Chain e: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	64-75	12
β-strand	83-84	2	58
α-helix	86-113	28
β-strand	118-119	2	59
α-helix	121-131	11

Chain E: 15 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	3-24	22
β-strand	27	1	62
α-helix	31-34	4
α-helix	38-45	8
α-helix	54-56	3
β-strand	59-61	3	63
β-strand	63	1	62
α-helix	65-70	6
β-strand	77-81	5	63
β-strand	86-87	2	64
α-helix	89-101	13
β-strand	106-111	6	63
β-strand	114-115	2	64
α-helix	117-122	6
α-helix	123-126	4
β-strand	130-135	6	63
α-helix	137-139	3
α-helix	143-145	3
α-helix	150	1
β-strand	151-154	4	65
α-helix	155-156	2
α-helix	157-167	11
α-helix	171-173	3
β-strand	176-177	2	65
α-helix	182-187	6
β-strand	194-201	8	65
β-strand	205-213	9	65

23 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1743	Komagataella phaffii GS115	C4R4Y0
DNA-directed RNA polymerase subunit beta	B	protein	1227	Komagataella phaffii GS115	C4QZQ7 (AlphaFold model)
RNA polymerase II third largest subunit B44, part of central core	C	protein	304	Komagataella phaffii GS115	C4R7L2 (AlphaFold model)
RNA polymerase II subunit B32	D	protein	186	Komagataella phaffii GS115	C4R2U9 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	214	Komagataella phaffii GS115	C4R3P8
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Komagataella phaffii GS115	C4R1V1
RNA polymerase II subunit	G	protein	171	Komagataella phaffii GS115	C4R9A1
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	145	Komagataella phaffii GS115	C4R273
DNA-directed RNA polymerase subunit	I	protein	115	Komagataella phaffii GS115	F2QPE6
RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III	J	protein	72	Komagataella phaffii GS115	C4R009
RNA polymerase II subunit B12.5	K	protein	118	Komagataella phaffii GS115	C4R3Z5
RNA polymerase subunit ABC10-alpha	L	protein	72	Komagataella phaffii GS115	F2QMI1

20 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9WMW_1 DNA-directed RNA polymerase subunit (chains A)
MSQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREGGLNDPKLGS
IDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKKVCECICMNCGKLLLDETNP
TMAQAIRIRDPKKRFNAVWQLCKTKMVCEADAPVDEYSEQKVVSRGGCGNTQPVVRKDGM
KLWGTWKKSGFSDRDAQPERKLLTPGEILNVFKHISPEDCFRLGFNEDYARPEWMIITVL
PVPPPQVRPSIAMDETTQGQDDLTHKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFH
VATYMDNDIAGQPQALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNL
ELDQVGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRIDLRYHK
RAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMPYSTFRLNLSVTSPYN
ADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPVMGIVQDTLCGVRKMTLRDT
FIEYEQVMNMLFWVPSWDGVVPQPAILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLS
PKDNGMLIVDGKVMFGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLH
NGFSIGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESFEGEVS
RTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSACVGQQMVEGKRIAFGF
ADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFFFHAMAGREGLIDTAVKTAETGYIQR
RLVKALEDIMVHYDGTTRNSLGDIIQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYV
DLMDEKNSIKPDVIEYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPV
NLRRIIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQNATSLF
QCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEMVGVIAAQSIGEPATQ
MTLNTFHYAGVSSKNVTLGVPRLKEILNVAKNIKTPALTVYLDREIALDIEKAKVIQSSI
EYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSIPDEKVEETIDKQSPWLLRLELD
RARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLIIRCRVIRDPKAMDEELEAEED
QMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYKNEELWALETDGINLAEVM
AVPGVDSSRTYSNSFVEILSVLGIEATRSSLYKEILNVIAFDGSYVNYRHMALLVDVMTS
RGYLMAITRHGINRADTGALMRCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMG
TGAFDVMIDEKLLTSLPADYAPTMPLFKGKATQGSATPYDNNAQYDDEFNHDDVADVMFS
PMAETGSGDDRSGGLTEYAGIQSPYQPTSPGLSATSPGFAPTSPGFAPTSPRYSPTSPGY
SPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTS
PSYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYS
PTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPASPQYSPSRHSPNGESK
EGE

Sequence of entity 2 (B), FASTA

>9WMW_2 DNA-directed RNA polymerase subunit beta (chains B)
MSYDPYSIDDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLILDQ
PAQHTNEKDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYSSPVYLDME
KSMFTSIDDEGNPNATLDWQQVHEPIKDGVEEGNKVHIGKVPIMLRSKFCSLRTLDEVDL
YKMKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALEKGSR
LISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPDGEILQHICYDENDW
QMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGIRREKRIQYAKDILQKELLPHITQE
EGFETRKTFFLGYMVNRLLLCALERKDQDDRDHFGKKRLDLAGPLLANLFRILFRKLTRE
IYRYMQRCIETDRDFNLNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYT
YSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLSGISI
GSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDPSMLVSTMRDLRRSG
AISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDDESKDNKGELRITKEHIRKIQQGYD
DDAMNDDSEEQEQDVYGWSSLVTSGVIEYVDGEEEETIMIAMTPEDLQTRSLEQKEIDLN
DTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGV
FLTNYNVRMDTMANILYYPQKPLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMI
MNQSSIDRGLFRSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIA
PGVRVSGDDIIIGKTTPIPPDTEELGQRTKYHTKRDASTPLRSTENGIVDQVLLTTNQEG
LKFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLIINPHAIPSR
MTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRDNGYQSRGFEVMYNGHTGKK
LMAQVFFGPTYYQRLRHMVDDKIHARARGPVQVLTRQPVEGRSRDGGLRFGEMERDCMIA
HGAAGFLKERLMEASDAFRVHVCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAA
KLLFQELMAMNIAPRLYTERSGVSMRS

Sequence of entity 3 (C), FASTA

>9WMW_3 RNA polymerase II third largest subunit B44, part of central core (chains C)
MSKEPKVNIINAQDDEVELMLSDVNLSLANSLRRTMLAEVPTLAIDLVEIKMNTSVLADE
FISHRLGLIPLVSEDVEEMKYSRDCTCEDYCDECSVVLELSARHEGEEGTTDVYSSSLIK
VSGPGNLNVGEPVRRDDYDQGILLCKLRNHQELNIRCIAKKGIAKEHAKWSPCSAIAFEY
DPHNKLKHTDFWFEVDAKKEWPDSKYATWEEPPKPGEVFDYKAKPNRFYMTVETTGSLKA
NQVFSRGIKTLQEKLANVLFELENSRPANTTAYGGATAYGGQTVYGRETSYGGNTNYGDY
NAPY

Sequence of entity 4 (D), FASTA

>9WMW_4 RNA polymerase II subunit B32 (chains D)
MNVSTSTVGARRRRAKQQVDDEENATLLRLGPEFALKQYDHDGNEHDLIALSLSESRLLI
REALKARSRARNGGVDIESSNGEIDDDELAKVTSGAVANGVVKKTLDYLNTFARFKDEET
CTAVDQLLHNSSDCSVLHPFEIAQLSSLGCEDVDEAITLIPSLAAKKEVNLQRILDELNR
LEDPYK

Sequence of entity 5 (E), FASTA

>9WMW_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MEDNNRIISRLWRSFRTVKEMAADRGYFISQEEMDQSLEEFRSKICDSMGNPQRKLMSFL
ANPTPEALEKYSDLGTLWVEFCDEPSVGIKTMRNFCLRIQEKNFSTGIFIYQNNITPSAN
KMIPTVSPAIIETFQESDLVVNITHHELVPKHIRLSDGEKSQLLQRYKLKESQLPRIQRE
DPVARYLGLKRGQVVKIIRRSETSGRYASYRICL

Sequence of entity 6 (F), FASTA

>9WMW_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSEDEAFNEQTENFENFEDEHFSDDNFEDRSTQPEDYAVGVTADGRQIINGDGIQEVNGT
IKAHRKRSNKELAILKEERTTTPYLTKYERARILGTRALQISMNAPVLVDIEGETDPLQI
AMKELSQRKIPLVIRRYLPDGSYEDWGCDELIVDN

Sequence of entity 7 (G), FASTA

>9WMW_7 RNA polymerase II subunit (chains G)
MFFLKDLSLILTLHPSYFGPQMNQYLREKLLTDVEGTCTGQFGYIVTVLDGMNIDVGKGR
IIPGSGSAEFEVKYRAVVWKPFKGEVVDAIVSNVSPIGFFADVGPLNVFVSTRLIPDNLV
YNPSNSPPAYMSNDELITKGSKVRLKVVGTRTDVNEIYAIGSIKEDFLGAI

Sequence of entity 8 (H), FASTA

>9WMW_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSSALFDDIFTVQTVDNGRYNKVSRIIGISTTNSAIKLTLDINNEMFPVSQDDSLTVTLA
NSLSLDGEDESANFSKSWRPPKPTDKSLADDYDYVMFGTVYKFEEGDEDKIKVYVSFGGL
LMCLEGGYKSLASLKQDNLYILIRR

Sequence of entity 9 (I), FASTA

>9WMW_9 DNA-directed RNA polymerase subunit (chains I)
MASFRFCLECNNMLYPKEDKENQRLLYSCRNCDYTELAEDPKVYRHELITNIGETAGIVD
DIGQDPTLPRSDKECPECHSRDCVFFQSQQRRKDTNMTLFYVCLNCKKTFRDESE

Sequence of entity 10 (J), FASTA

>9WMW_10 RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III (chains J)
MIIPVRCFSCGKVVGDKWDAYLRLLEEGKQEGDALDELKLKRYCCRRMVLTHVDLIEKFL
RYNPLEKKDFDS

Sequence of entity 11 (K), FASTA

>9WMW_11 RNA polymerase II subunit B12.5 (chains K)
MNAPDRFELFILPDDVPKLKITPDSRVPNCIIIKFEREDHTLANLLREELALYPDVTFVA
YKVEHPLFANFVMRLQTEEGTRPKQALERACASIINKLKTLDHKFNEEWNIKNFSLND

Sequence of entity 12 (L), FASTA

>9WMW_12 RNA polymerase subunit ABC10-alpha (chains L)
MSREGFVAPSGTDLAAAASGVAPNKHYGVKYTCGACAHNFSLNKSDPVRCKECGHRVIYK
ARTKRMIQFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	10

Primary citation

Structural basis of transcription-coupled H3K36 trimethylation by Set2 in coordination with FACT. Kujirai, T., Ehara, H., Ito, T. et al. Sci Adv (2026) 12:eaed1952-eaed1952. DOI 10.1126/sciadv.aed1952 · PubMed

Other PDB entries of the same protein (UniProt C4R4Y0), best resolution first:

5XOG 3.0 Å, RNA Polymerase II elongation complex bound with Spt5 KOW5 and Elf1
7XN7 3.1 Å, RNA polymerase II elongation complex containing Spt4/5, Elf1, Spt6, Spn1 and Paf1C
8JH4 3.2 Å, RNA polymerase II elongation complex containing 60 bp upstream DNA loop, stalled at…
8YFQ 3.3 Å, Cryo EM structure of Komagataella phaffii RNAPII-Rat1-Rai1 pre-termination complex
7XSZ 3.4 Å, RNA polymerase II elongation complex transcribing a nucleosome (EC115)
8YFR 3.4 Å, Cryo EM structure of Komagataella phaffii Rat1-Rai1 complex bound within the RNAPII cleft
9WMS 3.4 Å, Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II…
9II7 3.5 Å, RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome containing…
9WMT 3.59 Å, Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II…
7XSE 3.6 Å, RNA polymerase II elongation complex transcribing a nucleosome (EC42)
9UJS 3.62 Å, RNA polymerase II elongation complex stalled at SHL(-4) of the H3-H4 octasome
8JH3 3.7 Å, RNA polymerase II elongation complex containing 40 bp upstream DNA loop, stalled at…

Browse structure collections

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