9Y3G: Helicase SRCAP

Extended cryo-EM structure of human SRCAP-CFDP1-nucleosome complex in the activated state. Determined by electron microscopy at 4.1 Å resolution. Released 12 Aug 2026.

Method: Electron microscopy
Resolution: 4.1 Å
Organisms: Homo sapiens, Xenopus laevis, synthetic construct
Chains: 25
Atoms: 55,610
Mol. weight: 1265.15 kDa
Ligands: ADP, ZN, MG, ATP
Released: 12 Aug 2026

Explore 9Y3G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9Y3G contains 348 α-helices and 309 β-strands across 23 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 55 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	136-251	116
α-helix	609-611	3
α-helix	617-619	3
α-helix	620-635	16
β-strand	639-643	5	1
α-helix	644	1
α-helix	649-659	11
α-helix	660-664	5
β-strand	670-673	4	1
α-helix	676-689	14
β-strand	695-697	3	1
α-helix	702-709	8
β-strand	720-723	4	1
α-helix	725-730	6
α-helix	732-737	6
β-strand	740-745	6	1
α-helix	748-751	4
α-helix	757-763	7
β-strand	767-773	7	1
α-helix	782-792	11
α-helix	800-803	4
α-helix	804-808	5
α-helix	809-815	7
α-helix	823-833	11
β-strand	837-840	4	1
α-helix	842-845	4
β-strand	852-859	8	2
α-helix	860-862	3
α-helix	863-874	12
α-helix	890-902	13
α-helix	904-906	3
α-helix	909-911	3
β-strand	913	1	3
β-strand	916-917	2	4
α-helix	919-921	3
β-strand	922-924	3	5
α-helix	929-931	3
α-helix	937-939	3
α-helix	943-946	4
α-helix	949-951	3
α-helix	957	1
α-helix	958-963	6
α-helix	964-967	4
β-strand	968	1	6
α-helix	971-979	9
α-helix	981-989	9
α-helix	1887-1910	24
α-helix	1920-1926	7
α-helix	1937-1938	2
α-helix	1946-1949	4
α-helix	1953-1957	5
α-helix	1962-1968	7
α-helix	1970-1976	7
β-strand	1983-1984	2	4
α-helix	1986-1988	3
β-strand	1989-1991	3	5
α-helix	1999-2014	16
α-helix	2015-2021	7
α-helix	2022-2029	8
β-strand	2031	1	3
α-helix	2037-2040	4
α-helix	2043-2058	16
β-strand	2062-2066	5	2
α-helix	2069-2082	14
β-strand	2086-2089	4	2
α-helix	2095-2107	13
β-strand	2113-2117	5	2
β-strand	2132-2135	4	2
α-helix	2142-2153	12
β-strand	2161-2168	8	2
α-helix	2172-2187	16
α-helix	2188-2192	5
α-helix	2198-2202	5
α-helix	2297-2307	11
α-helix	2311-2350	40

Chain B: 8 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	135-153	19
α-helix	155-158	4
α-helix	166-168	3
α-helix	169-196	28
β-strand	211-220	10	7
β-strand	260-268	9	7
α-helix	271-277	7
α-helix	281-288	8
β-strand	291	1	8
β-strand	298	1	8
α-helix	299	1
β-strand	301-302	2	9
β-strand	309-310	2	9
α-helix	313-330	18

Chain C: 21 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	2-8	7	10
β-strand	12-17	6	10
β-strand	23-26	4	10
β-strand	29-31	3	11
β-strand	40-41	2	11
α-helix	42-46	5
β-strand	55-57	3	11
β-strand	60-61	2	12
β-strand	64-65	2	12
α-helix	68-79	12
α-helix	88-90	3
β-strand	91-96	6	10
α-helix	103-111	9
α-helix	112-116	5
β-strand	121-125	5	10
α-helix	127-138	12
β-strand	145-150	6	13
β-strand	155-160	6	13
β-strand	165	1	13
α-helix	167-169	3
β-strand	171-173	3	13
α-helix	177-191	15
β-strand	193	1	14
α-helix	199-209	11
α-helix	216-224	9
β-strand	234-237	4	15
β-strand	248-249	2	15
α-helix	250-251	2
α-helix	252-254	3
β-strand	267-270	4	15
α-helix	273-282	10
α-helix	284-286	3
α-helix	294-304	11
α-helix	310-314	5
β-strand	317-320	4	13
α-helix	322-325	4
α-helix	329-340	12
β-strand	342	1	16
β-strand	349-350	2	13
α-helix	358-368	11
α-helix	372-375	4
β-strand	377-378	2	10
α-helix	379-393	15

Chain D: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	21-34	14
α-helix	84-91	8
β-strand	105	1	13
α-helix	112-115	4
β-strand	116	1	17
β-strand	123	1	17
β-strand	126-127	2	18
β-strand	134-135	2	18
α-helix	138-147	10

Chain E: 23 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	19
β-strand	26	1	20
α-helix	31	1
β-strand	32	1	20
α-helix	33	1
β-strand	36	1	21
β-strand	39	1	21
α-helix	43-58	16
β-strand	61	1	22
β-strand	65-69	5	23
α-helix	76-87	12
β-strand	93-96	4	23
α-helix	98-101	4
α-helix	108-118	11
β-strand	121-141	21	24
β-strand	156-162	7	24
β-strand	167-172	6	24
α-helix	174-182	9
β-strand	189-194	6	24
β-strand	199-206	8	24
α-helix	207-209	3
β-strand	215	1	7
β-strand	220-221	2	24
α-helix	222-224	3
β-strand	229-239	11	24
α-helix	240-248	9
α-helix	256-264	9
α-helix	273-288	16
β-strand	292-295	4	24
β-strand	298-301	4	23
α-helix	304-306	3
β-strand	308	1	25
α-helix	309-320	12
β-strand	326-331	6	23
β-strand	333	1	26
β-strand	336-337	2	27
α-helix	338	1
β-strand	339	1	25
β-strand	345-346	2	27
α-helix	352-355	4
β-strand	358-362	5	23
α-helix	365-367	3
α-helix	368-381	14
β-strand	386	1	28
α-helix	388-399	12
α-helix	403-408	6
α-helix	410-419	10
β-strand	425	1	28
α-helix	427-436	10
β-strand	438	1	29
α-helix	440-449	10
β-strand	455	1	30

Chain F: 23 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	31
β-strand	33	1	32
α-helix	38	1
β-strand	39	1	32
α-helix	40	1
β-strand	42-43	2	33
β-strand	46-47	2	33
α-helix	50-65	16
β-strand	68	1	19
β-strand	72-77	6	29
α-helix	83-94	12
β-strand	100-104	5	29
α-helix	105-108	4
α-helix	115-124	10
β-strand	127-150	24	7
β-strand	158-164	7	7
β-strand	169-174	6	7
α-helix	176-185	10
β-strand	191-196	6	7
β-strand	202-207	6	7
α-helix	210	1
β-strand	211	1	7
α-helix	212	1
α-helix	226-228	3
β-strand	233-243	11	7
α-helix	244-252	9
α-helix	256-262	7
α-helix	270-285	16
β-strand	289-293	5	7
β-strand	295-299	5	29
α-helix	301-303	3
β-strand	305	1	34
α-helix	306-315	10
β-strand	323-328	6	29
β-strand	330	1	30
β-strand	332-334	3	35
α-helix	335	1
β-strand	336	1	34
β-strand	341-343	3	35
α-helix	348-351	4
β-strand	354-359	6	29
α-helix	360-362	3
α-helix	364-377	14
β-strand	382	1	36
α-helix	384-396	13
α-helix	399-415	17
β-strand	421	1	36
α-helix	423-432	10
β-strand	434	1	37
α-helix	436-445	10

Chain G: 24 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	38
β-strand	26	1	39
α-helix	31	1
β-strand	32	1	39
α-helix	33	1
β-strand	35-36	2	40
β-strand	39-40	2	40
α-helix	43-58	16
β-strand	61	1	31
β-strand	65-69	5	37
α-helix	76-87	12
β-strand	93-97	5	37
α-helix	98-101	4
α-helix	108-119	12
β-strand	120-142	23	7
β-strand	152-163	12	7
β-strand	166-172	7	7
α-helix	176-182	7
β-strand	189-194	6	7
β-strand	199-206	8	7
α-helix	207-209	3
β-strand	214	1	41
β-strand	220-221	2	7
α-helix	222-225	4
β-strand	229-239	11	7
α-helix	240-248	9
α-helix	256-263	8
α-helix	265-266	2
α-helix	273-289	17
β-strand	292-296	5	7
β-strand	298-302	5	37
α-helix	304-306	3
β-strand	308	1	42
α-helix	309-320	12
β-strand	326-331	6	37
β-strand	336-337	2	43
α-helix	338	1
β-strand	339	1	42
β-strand	345-346	2	43
α-helix	352-355	4
β-strand	358-362	5	37
α-helix	364-367	4
α-helix	368-381	14
β-strand	386	1	44
α-helix	388-399	12
α-helix	403-408	6
α-helix	410-420	11
β-strand	425	1	44
α-helix	427-436	10
β-strand	438	1	45
α-helix	440-449	10
β-strand	455	1	46

Chain H: 23 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	47
β-strand	33	1	48
α-helix	38	1
β-strand	39	1	48
α-helix	40	1
β-strand	42-43	2	49
β-strand	46-47	2	49
α-helix	50-65	16
β-strand	68	1	38
β-strand	72-77	6	45
α-helix	83-93	11
β-strand	100-104	5	45
α-helix	105-108	4
α-helix	115-125	11
β-strand	127-148	22	41
β-strand	158-164	7	41
β-strand	169-174	6	41
α-helix	176-184	9
β-strand	191-196	6	41
β-strand	202-207	6	41
α-helix	211-213	3
β-strand	217	1	16
β-strand	224	1	41
β-strand	225	1	6
α-helix	226-228	3
β-strand	233-243	11	41
α-helix	244-250	7
α-helix	256-258	3
α-helix	259-262	4
α-helix	270-286	17
β-strand	289-293	5	41
β-strand	295-299	5	45
α-helix	301-303	3
β-strand	305	1	50
α-helix	306-315	10
β-strand	323-328	6	45
β-strand	330	1	46
β-strand	333-334	2	51
α-helix	335	1
β-strand	336	1	50
β-strand	341-342	2	51
α-helix	348-351	4
β-strand	354-359	6	45
α-helix	360-362	3
α-helix	364-378	15
β-strand	382	1	52
α-helix	384-396	13
α-helix	399-415	17
β-strand	421	1	52
α-helix	423-432	10
β-strand	434	1	53
α-helix	436-445	10
β-strand	451	1	54

14 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Helicase SRCAP	A	protein	3230	Homo sapiens	Q6ZRS2
Vacuolar protein sorting-associated protein 72 homolog	B	protein	364	Homo sapiens	Q15906 (AlphaFold model)
Actin-related protein 6	C	protein	396	Homo sapiens	Q9GZN1 (AlphaFold model)
Zinc finger HIT domain-containing protein 1	D	protein	154	Homo sapiens	O43257 (AlphaFold model)
RuvB-like 1	E, G, I	protein	456	Homo sapiens	Q9Y265
RuvB-like 2	F, H, J	protein	463	Homo sapiens	Q9Y230
Actin-like protein 6A	K, M	protein	429	Homo sapiens	O96019
Actin, cytoplasmic 1	L	protein	375	Homo sapiens	P60709
DNA methyltransferase 1-associated protein 1	N	protein	467	Homo sapiens	Q9NPF5
Craniofacial development protein 1	P	protein	299	Homo sapiens	Q9UEE9
Histone H2A type 1	Q, S	protein	128	Xenopus laevis	P06897
Histone H2B 1.1	R, T	protein	125	Xenopus laevis	P02281

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9Y3G_1 Helicase SRCAP (chains A)
MQSSPSPAHPQLPVLQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGP
PGPPDGATVPLEGFSLSQAADLANKGPKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWS
LKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKE
ERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQT
EKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDE
ETIEVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSD
TRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAE
EQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPE
GPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQA
DEEEEDDDFGVEYLLARDEEQSEADAGSGPPTPGPTTLGPKKEITDIAAAAESLQPKGYT
LATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHL
ACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHV
CITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQN
SLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR
VKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKV
CNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEA
DTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLG
PVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSG
SLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFP
PAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVAN
AGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALI
QAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDG
LTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHS
PSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLP
ISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASP
SASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFP
SAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAP
VLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQT
LALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPL
GPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGP
AAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSP
PSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGT
EVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVM
PPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQY
DCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQA
LMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRD
VHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSS
SVPSAPEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAG
EGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVE
AARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLR
GARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPV
PVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCL
VTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLV
PPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGE
ELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAA
PSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEE
KELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTP
PQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEA
PSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRG
RPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTTVTIST
SPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGS
RPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRST
RLRPGSLVPPLETEKLPRKRAGAPVGGSPGLAKRGRLQPPSPLGPEGSVEESEAEASGEE
EEGDGTPRRRPGPRRLVGTTNQGDQRILRSSAPPSLAGPAVSHRGRKAKT

Sequence of entity 2 (B), FASTA

>9Y3G_2 Vacuolar protein sorting-associated protein 72 homolog (chains B)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK

Sequence of entity 3 (C), FASTA

>9Y3G_3 Actin-related protein 6 (chains C)
MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPF
QKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQ
AVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLL
TNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPD
FSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVY
SIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAW
EGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI

Sequence of entity 4 (D), FASTA

>9Y3G_4 Zinc finger HIT domain-containing protein 1 (chains D)
MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDD
DADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVC
GFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV

Sequence of entity 5 (E, G, I), FASTA

>9Y3G_5 RuvB-like 1 (chains E, G, I)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK

Sequence of entity 6 (F, H, J), FASTA

>9Y3G_6 RuvB-like 2 (chains F, H, J)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS

Sequence of entity 7 (K, M), FASTA

>9Y3G_7 Actin-like protein 6A (chains K, M)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP

Sequence of entity 8 (L), FASTA

>9Y3G_8 Actin, cytoplasmic 1 (chains L)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Sequence of entity 9 (N), FASTA

>9Y3G_9 DNA methyltransferase 1-associated protein 1 (chains N)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP

Sequence of entity 10 (P), FASTA

>9Y3G_10 Craniofacial development protein 1 (chains P)
MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQTQKTQGKKRKAQSIPA
RKRRQGGLSLEEEEEEDANSESEGSSSEEEDDAAEQEKGIGSEDARKKKEDELWASFLND
VGPKSKVPPSTQVKKGEETEETSSSKLLVKAEELEKPKETEKVKITKVFDFAGEEVRVTK
EVDATSKEAKSFFKQNEKEKPQANVPSALPSLPAGSGLKRSSGMSSLLGKIGAKKQKMST
LEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP

Sequence of entity 11 (Q, S), FASTA

>9Y3G_11 Histone H2A type 1 (chains Q, S)
SGRGKQGGKTRAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPKKT
ESSKSKSK

Sequence of entity 12 (R, T), FASTA

>9Y3G_12 Histone H2B 1.1 (chains R, T)
PEPAKSAPAPKKGSKKAVTKTQKKDGKKRRKTRKESYAIYVYKVLKQVHPDTGISSKAMS
IMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTK
YTSAK

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	6
ZN	Zinc ion	Zn	2
MG	Magnesium ion	Mg	6
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	3

Primary citation

Structural mechanism of histone H2A.Z exchange by human SRCAP-CFDP1 holoenzyme. Park, G., Wu, C., Louder, R.K. Sci Adv (2026) 12:eaei7728-eaei7728. DOI 10.1126/sciadv.aei7728 · PubMed

Other PDB entries of the same protein (UniProt Q6ZRS2), best resolution first:

9UBD 2.53 Å, The Structural Basis of the Recognition of the Histone Variant H2A.Z by the SRCAP…
8X15 3.2 Å, Structure of nucleosome-bound SRCAP-C in the apo state
8X19 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state
8X1C 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-bound state
9NFX 3.3 Å, Human SRCAP-CFDP1-hexasome complex in the evicted state of the H2A.Z histone exchange…
9CA7 3.35 Å, Cryo-EM structure of human SRCAP-nucleosome complex in the fully-engaged state…
9NFY 3.4 Å, Human SRCAP-CFDP1-prenucleosome complex in the pre-inserted state of the H2A.Z histone…
9CA9 3.56 Å, Cryo-EM structure of the human SRCAP complex in the unbound state (composite structure)
9NFV 3.8 Å, Human SRCAP-CFDP1-nucleosome complex in the poised state of the H2A.Z histone exchange…
9NFW 3.8 Å, Human SRCAP-CFDP1-nucleosome complex in the activated state of the H2A.Z histone…
9NFZ 3.8 Å, Human SRCAP-nucleosome complex in the fully inserted state of the H2A.Z histone exchange…
9PGC 3.8 Å, Trident submodule from human SRCAP-nucleosome complex in the fully-engaged state…

Browse structure collections

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