Translation Initiation Factor eIF-2B complex with the Isohexide Diamine GSK735. Determined by X-ray diffraction at 2.25 Å resolution. Released 4 Mar 2026.
Explore 9ZUZ in 3D Show helices and sheets RCSB PDB PDBe
9ZUZ contains 61 α-helices and 38 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 3-16 | 14 | |
| α-helix | 22-36 | 15 | |
| α-helix | 42-59 | 18 | |
| α-helix | 63-80 | 18 | |
| α-helix | 86-104 | 19 | |
| α-helix | 107-115 | 9 | |
| α-helix | 116-118 | 3 | |
| β-strand | 123-128 | 6 | 1 |
| α-helix | 132-143 | 12 | |
| β-strand | 148-153 | 6 | 1 |
| α-helix | 160-170 | 11 | |
| β-strand | 175-178 | 4 | 1 |
| α-helix | 180-182 | 3 | |
| α-helix | 183-186 | 4 | |
| α-helix | 187-189 | 3 | |
| β-strand | 192-195 | 4 | 1 |
| β-strand | 199-200 | 2 | 2 |
| β-strand | 206-209 | 4 | 2 |
| α-helix | 212-221 | 10 | |
| β-strand | 226-229 | 4 | 1 |
| α-helix | 232-234 | 3 | |
| β-strand | 235 | 1 | 2 |
| α-helix | 248-251 | 4 | |
| β-strand | 273-276 | 4 | 2 |
| α-helix | 278-280 | 3 | |
| β-strand | 283-286 | 4 | 1 |
| β-strand | 289-291 | 3 | 1 |
| α-helix | 293-303 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 9-24 | 16 | |
| α-helix | 31-48 | 18 | |
| α-helix | 54-71 | 18 | |
| α-helix | 76-97 | 22 | |
| α-helix | 109-113 | 5 | |
| α-helix | 119-121 | 3 | |
| α-helix | 129-145 | 17 | |
| α-helix | 147-152 | 6 | |
| α-helix | 155-157 | 3 | |
| β-strand | 164-168 | 5 | 3 |
| α-helix | 172-182 | 11 | |
| β-strand | 188-192 | 5 | 3 |
| α-helix | 199-209 | 11 | |
| β-strand | 213-217 | 5 | 3 |
| α-helix | 219-221 | 3 | |
| α-helix | 222-226 | 5 | |
| β-strand | 231-234 | 4 | 3 |
| β-strand | 238-239 | 2 | 4 |
| β-strand | 245-248 | 4 | 4 |
| α-helix | 251-260 | 10 | |
| β-strand | 265-268 | 4 | 3 |
| α-helix | 271-273 | 3 | |
| β-strand | 274 | 1 | 4 |
| β-strand | 288 | 1 | 5 |
| α-helix | 291-294 | 4 | |
| α-helix | 300-303 | 4 | |
| β-strand | 311 | 1 | 5 |
| β-strand | 313-316 | 4 | 4 |
| α-helix | 318-320 | 3 | |
| β-strand | 323-326 | 4 | 3 |
| β-strand | 329-331 | 3 | 3 |
| α-helix | 333-335 | 3 | |
| α-helix | 336-343 | 8 | |
| α-helix | 346-348 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 178-180 | 3 | |
| β-strand | 185 | 1 | 6 |
| α-helix | 191-196 | 6 | |
| α-helix | 205-215 | 11 | |
| α-helix | 222-238 | 17 | |
| α-helix | 242-243 | 2 | |
| α-helix | 248-266 | 19 | |
| α-helix | 268-270 | 3 | |
| α-helix | 271-285 | 15 | |
| α-helix | 293-308 | 16 | |
| α-helix | 309-314 | 6 | |
| α-helix | 315-324 | 10 | |
| β-strand | 332-336 | 5 | 7 |
| α-helix | 340-351 | 12 | |
| β-strand | 357-362 | 6 | 7 |
| α-helix | 369-378 | 10 | |
| β-strand | 383-387 | 5 | 7 |
| α-helix | 388-390 | 3 | |
| α-helix | 391-394 | 4 | |
| α-helix | 395-397 | 3 | |
| β-strand | 400-404 | 5 | 7 |
| β-strand | 407-408 | 2 | 8 |
| β-strand | 414-417 | 4 | 8 |
| α-helix | 420-429 | 10 | |
| β-strand | 434-437 | 4 | 7 |
| α-helix | 440-442 | 3 | |
| β-strand | 443 | 1 | 8 |
| β-strand | 457 | 1 | 6 |
| α-helix | 460-463 | 4 | |
| α-helix | 476-478 | 3 | |
| β-strand | 487 | 1 | 6 |
| β-strand | 489-492 | 4 | 8 |
| α-helix | 494-496 | 3 | |
| β-strand | 499-502 | 4 | 7 |
| β-strand | 505-507 | 3 | 7 |
| α-helix | 509-511 | 3 | |
| α-helix | 512-518 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Translation initiation factor eIF-2B subunit alpha | A | protein | 305 | Homo sapiens | Q14232 (AlphaFold model) |
| Translation initiation factor eIF-2B subunit beta | B | protein | 351 | Homo sapiens | P49770 (AlphaFold model) |
| Translation initiation factor eIF2B subunit delta | D | protein | 370 | Homo sapiens | Q9UI10 (AlphaFold model) |
>9ZUZ_1 Translation initiation factor eIF-2B subunit alpha (chains A) MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL IKLYL
>9ZUZ_2 Translation initiation factor eIF-2B subunit beta (chains B) MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMEL IRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNE DFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKE AARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTIL ANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEG DILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL
>9ZUZ_3 Translation initiation factor eIF2B subunit delta (chains D) MRQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGS NARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNK EITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLV SRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVL LGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDD LQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD QSGGHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| PRO | Proline | C5 H9 N O2 | 1 |
| A1C32 | 1,4:3,6-dianhydro-2,5-bis[2-(4-chlorophenoxy)acetamido]-2,5-dideoxy-D-glucitol | C22 H22 Cl2 N2 O6 | 1 |
Water and common crystallization additives (SO4, EDO) are not listed.
Discovery of Isohexide Bisglycolamides as Inhibitors of the Integrated Stress Response. Colandrea, V.J., Joshi-Pangu, A., Nolte, R.T. et al. ACS Med Chem Lett (2026) 17:495-502. DOI 10.1021/acsmedchemlett.5c00698 · PubMed
Other PDB entries of the same protein (UniProt Q14232 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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