Dynactin subunit 2 (DCTN2) is a 405-residue protein from Sus scrofa. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A0A5G2QD80.
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The mean pLDDT of this model is 74.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)
Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3 (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160). The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its…
Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Z8M | EM | 3.37 Å | M=1-405 |
| 6F1U | EM | 3.4 Å | c=1-50, d=1-26 |
| 5AFU | EM | 3.5 Å | a=1-48 |
| 6F1T | EM | 3.5 Å | a=1-66, b=1-89, c=1-50, d=1-26 |
| 6ZNL | EM | 3.8 Å | M/N/m/n=1-405 |
| 9DGS | EM | 3.9 Å | M/N/P/Q=1-405 |
| 5ADX | EM | 4.0 Å | a=1-48 |
| 9YNG | EM | 4.07 Å | M/N/P/Q=1-405 |
| 6ZNM | EM | 4.1 Å | M=1-405 |
| 6ZNN | EM | 4.5 Å | M=1-405 |
| 9HHL | EM | 6.53 Å | M/N/P/Q/V=1-405 |
| 6F38 | EM | 6.7 Å | a=1-68, b=1-90, d=1-29 |
| 6ZNO | EM | 6.8 Å | M=1-405 |
| 9DGU | EM | 7.1 Å | M/N/P/Q=1-405 |
| 9DGT | EM | 7.2 Å | M/N/P/Q=1-405 |
| 6F3A | EM | 8.2 Å | a=1-68, b/c/d=1-89 |
| 6ZO4 | EM | 8.2 Å | M=1-405 |
| 5NW4 | EM | 8.7 Å | k=1-64 |
| 9DGV | EM | 8.8 Å | M/N/P/Q=1-405 |
| 8PTK | EM | 10.0 Å | M/N/P/Q=1-405 |
Showing 20 of 22 experimental structures (best resolution first).
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