Actin nucleation-promoting factor WASL (WASL) is a 505-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00401.
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The mean pLDDT of this model is 68.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 28% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting…
Binds actin and the Arp2/3 complex (PubMed:22847007). Interacts with CDC42 (PubMed:9422512, PubMed:16246732). Interacts with FCHSD1 (By similarity). Interacts with FCHSD2 (PubMed:29887380). Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP (PubMed:17015620, PubMed:19767742, PubMed:24332715). Interacts with SNX9 (By similarity). Interacts with the WW domains of…
Cytoplasm, cytoskeleton, Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CC2 | X-ray | 1.55 Å | B/D=346-357 |
| 4CC7 | X-ray | 1.97 Å | B/D/F/H/J/L/N=346-357 |
| 2FF3 | X-ray | 2.0 Å | C=451-465 |
| 9DLX | EM | 2.91 Å | H/I=465-505 |
| 2VCP | X-ray | 3.2 Å | D/E=392-484 |
| 2LNH | NMR | A=207-270 | |
| 9R3Y | NMR | A=207-275 | |
| 9R4V | NMR | A=207-275 |
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