Protection of telomeres protein tpz1 (tpz1) is a 508-residue protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14246.
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The mean pLDDT of this model is 56.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 55% |
What pLDDT means and how to read it
Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation. recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positively respectively
Interacts with ccq1, pot1 and poz1
Chromosome, telomere, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5WE0 | X-ray | 2.3 Å | B/E/H/K=476-508 |
| 7CUJ | X-ray | 2.4 Å | C/D=426-470 |
| 5WE2 | X-ray | 2.5 Å | B/D=476-508 |
| 5XXE | X-ray | 2.5 Å | C/D=477-508 |
| 7CUI | X-ray | 2.6 Å | B/D=164-240 |
| 5XXF | X-ray | 3.1 Å | C/D=478-508 |
| 5WE1 | X-ray | 3.2 Å | B/D=476-508 |
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