Transcription regulator protein BACH1 (BACH1) is a 736-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14867.
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The mean pLDDT of this model is 56.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 57% |
What pLDDT means and how to read it
Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498)
Heterodimer of BACH1 and MAFK
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GRA | X-ray | 1.47 Å | A/B=7-128 |
| 9GP5 | X-ray | 1.9 Å | C/D=7-128 |
| 9GR9 | X-ray | 2.25 Å | A/B/C/D=7-128 |
| 2IHC | X-ray | 2.44 Å | A/B/C/D=7-128 |
| 8UBT | EM | 3.1 Å | D=7-128 |
| 8S7D | EM | 3.2 Å | A/B=7-128 |
| 8UAH | EM | 3.3 Å | C=7-132 |
| 8UA3 | EM | 3.8 Å | D/E=7-128 |
| 8UA6 | EM | 3.9 Å | D/E=7-128 |
| 8UBV | EM | 4.1 Å | C/I=7-128 |
| 29HH | EM | 4.2 Å | G/H=1-736 |
| 8UBU | EM | 4.6 Å | E/L=7-128 |
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