Rho guanine nucleotide exchange factor 11 (ARHGEF11) is a 1522-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15085.
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The mean pLDDT of this model is 59.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 52% |
What pLDDT means and how to read it
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth
Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with SLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus). Found in a complex with ARHGEF11 and ARHGEF12; binding to ARHGEF11 and ARHGEF12 enhances CDC42 GEF activity of PLEKHG4B, and PLEKHG4B, in turn, inhibits ARHGEF11- and ARHGEF12-mediated RHOA activation…
Cytoplasm, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1HTJ | X-ray | 2.2 Å | F=281-490 |
| 5JHH | X-ray | 2.3 Å | A/E=714-1081 |
| 5TYT | X-ray | 2.4 Å | A/B/C/D=40-126 |
| 1XCG | X-ray | 2.5 Å | A/E=714-1081 |
| 5JHG | X-ray | 2.5 Å | A/E=714-1081 |
| 3KZ1 | X-ray | 2.7 Å | A/B=710-1085 |
| 3T06 | X-ray | 2.84 Å | A/E=672-1081 |
| 5E6P | X-ray | 3.21 Å | B=42-125 |
| 2DLS | NMR | A=44-123 |
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