Tumor protein p73 (TP73) is a 636-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15350.
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The mean pLDDT of this model is 65.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761)
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5HOB | X-ray | 1.22 Å | A/B/C/D/E/F/G/H=351-398 |
| 5HOC | X-ray | 1.36 Å | A/B=351-398 |
| 2WQI | X-ray | 1.7 Å | A/B/C/D=350-399 |
| 8P9C | X-ray | 1.76 Å | B=351-398 |
| 9GNB | X-ray | 1.8 Å | A=489-550 |
| 2XWC | X-ray | 1.82 Å | A=112-311 |
| 2WQJ | X-ray | 2.0 Å | 1/2/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z=350-383 |
| 9GLQ | X-ray | 2.1 Å | A/B=351-398 |
| 8P9E | X-ray | 2.25 Å | B=351-398 |
| 4A63 | X-ray | 2.27 Å | A/C/E/G/I/K=112-311 |
| 2WTT | X-ray | 2.3 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=350-399 |
| 1DXS | X-ray | 2.54 Å | A=487-564 |
| 8P9D | X-ray | 2.7 Å | B/D=351-398 |
| 5KBD | X-ray | 2.8 Å | A/B=115-312 |
| 7EZJ | X-ray | 2.9 Å | A/B/C/D/I/J/K/L/a/b/c/d/i/j/k/l=115-312 |
| 3VD0 | X-ray | 2.95 Å | A/B/C/D/I/J/K/L=115-312 |
| 3VD1 | X-ray | 2.95 Å | A/B/C/D/I/J/K/L=115-312 |
| 4G82 | X-ray | 3.1 Å | A/B=115-312 |
| 4GUO | X-ray | 3.19 Å | A/B/C/D/I/J/K/L=115-312 |
| 4GUQ | X-ray | 3.7 Å | A/B=115-312 |
Showing 20 of 28 experimental structures (best resolution first).
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