4ZIE: Core/latch dimer of Bax

Crystal Structure of core/latch dimer of Bax in complex with BimBH3. Determined by X-ray diffraction at 1.8 Å resolution. Released 22 Jul 2015.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,419
Mol. weight: 21.85 kDa
Released: 22 Jul 2015

Explore 4ZIE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4ZIE contains 10 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 0 β-strands

Element	Residues	Length
α-helix	16-34	19
α-helix	48-51	4
α-helix	54-71	18
α-helix	74-82	9
α-helix	88-99	12
α-helix	107-143	37
α-helix	144-148	5
α-helix	149-154	6
α-helix	159-164	6

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	144-162	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Apoptosis regulator BAX	A	protein	168	Homo sapiens	Q07812 (AlphaFold model)
Bcl-2-like protein 11	C	protein	26	Homo sapiens	O43521 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4ZIE_1 Apoptosis regulator BAX (chains A)
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLS
ESLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKL
VLKALSTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGSS

Sequence of entity 2 (C), FASTA

>4ZIE_2 Bcl-2-like protein 11 (chains C)
DMRPEIWIAQELRRIGDEFNAYYARR

Primary citation

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction. Robin, A.Y., Krishna Kumar, K., Westphal, D. et al. Cell Death Dis (2015) 6:e1809-e1809. DOI 10.1038/cddis.2015.141 · PubMed

Other PDB entries of the same protein (UniProt Q07812 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5W60 1.8 Å, Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol
4S0O 1.9 Å, Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)
5W5Z 2.0 Å, Crystal structure of BAXP168G in complex with an activating antibody at high resolution
6EB6 2.02 Å, Crystal structure of BAX W139A monomer
8SRX 2.09 Å, Crystal structure of BAK-BAX heterodimer with lysoPC
8G1T 2.09 Å, Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P21
6TRR 2.12 Å, Structural insight into tanapoxvirus mediated inhibition of apoptosis
4ZII 2.19 Å, Crystal Structure of core/latch dimer of BaxI66A in complex with BidBH3
4ZIG 2.2 Å, Crystal Structure of core/latch dimer of Bax in complex with BidBH3mini
8SPF 2.2 Å, Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with…
4BD2 2.21 Å, Bax domain swapped dimer in complex with BidBH3
7ADT 2.21 Å, Orf virus Apoptosis inhibitor ORFV125

Browse structure collections

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