Receptor activity-modifying protein 2 (RAMP2) is a 175-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60895.
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The mean pLDDT of this model is 80.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:9620797). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form a receptor complex for adrenomedullin/ADM (PubMed:22102369, PubMed:32296767, PubMed:9620797). Together with CALCR, act as a receptor complex for calcitonin/CT/CALC (PubMed:35324283). Together with CALCR, also act as a receptor complex for amylin/IAPP (PubMed:35324283)
Heterodimer of CALCRL and RAMP2; the interaction forms the receptor complex for adrenomedullin/ADM (PubMed:30115739). Heterodimer of CALCR and RAMP2; interaction forms the AMYR2 receptor complex for calcitonin/CALC and amylin/IAPP (PubMed:35324283)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4RWF | X-ray | 1.76 Å | A=49-138 |
| 6V2E | X-ray | 1.83 Å | A=55-140 |
| 3AQE | X-ray | 2.0 Å | A/B/C/D/E/F=56-139 |
| 2XVT | X-ray | 2.05 Å | A/B/C/D/E/F=48-139 |
| 7TYX | EM | 2.55 Å | E=44-175 |
| 3AQF | X-ray | 2.6 Å | A=56-139 |
| 9BQ3 | EM | 2.8 Å | E=44-175 |
| 6UUN | EM | 3.0 Å | E=44-175 |
| 7TYY | EM | 3.0 Å | E=44-175 |
| 7TYH | EM | 3.3 Å | E=44-175 |
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