Liprin-alpha-2 (PPFIA2) is a 1257-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75334.
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The mean pLDDT of this model is 66.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165)
Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with KIF1A; the interaction decreases in presence of calcium (PubMed:30021165)
Cytoplasm, Cell surface, Cell projection, dendritic spine
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7D2E | X-ray | 1.7 Å | A/B/C/D=164-235 |
| 7D2G | X-ray | 1.7 Å | A/B/C/D=102-150 |
| 6IUH | X-ray | 1.8 Å | C/D=642-671 |
| 3TAC | X-ray | 2.2 Å | B=866-1193 |
| 7D2H | X-ray | 2.2 Å | A/B/C/D=102-163 |
| 8Z22 | X-ray | 2.75 Å | C/D=300-404 |
| 3TAD | X-ray | 2.9 Å | A/B=866-1193 |
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