Cryptochrome-1 (cry) is a 542-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O77059.
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The mean pLDDT of this model is 95.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Blue light-dependent regulator that is the input of the circadian feedback loop (PubMed:10063806, PubMed:10233998, PubMed:10417378, PubMed:16527739, PubMed:17298948, PubMed:18597555, PubMed:36994075, PubMed:9845369). Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts (PubMed:10063806). Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms (PubMed:10063806, PubMed:10233998, PubMed:9845369). Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells (PubMed:10417378, PubMed:16527739, PubMed:36994075,…
Interacts with tim and per; promoted by light conditions (PubMed:10417378, PubMed:11448767). Interaction with tim irreversibly commits tim to proteasomal degradation (PubMed:10417378). Interacts with l(1)G0136/CG8198 (PubMed:26569474)
Cytoplasm, Cytoplasm, perinuclear region, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4GU5 | X-ray | 2.3 Å | A/B=1-539 |
| 4JZY | X-ray | 2.34 Å | A/B=1-540 |
| 6WTB | X-ray | 2.58 Å | A/B=1-539 |
| 4K03 | X-ray | 3.2 Å | A/B=1-542 |
| 8DD7 | EM | 3.3 Å | A=1-520 |
| 7UD0 | X-ray | 3.5 Å | A/B=1-539 |
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