Leucine-rich glioma-inactivated protein 1 (LGI1) is a 557-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O95970.
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The mean pLDDT of this model is 92.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (PubMed:15047712)
Oligomer. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1. Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2/Stargazin (PubMed:27066583). Can bind to ADAM11 and ADAM23 (By similarity)
Secreted, Synapse, Cytoplasm, Golgi apparatus, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5Y30 | X-ray | 1.78 Å | A=37-223 |
| 5Y2Z | X-ray | 2.67 Å | B/D/F/H/J/L=224-557 |
| 9KZC | EM | 2.78 Å | B/D=37-557 |
| 8HQ2 | X-ray | 2.93 Å | D/E=39-557 |
| 8Y6B | X-ray | 3.49 Å | D/E/F=39-557 |
| 9KZT | EM | 3.79 Å | B/D/F=37-557 |
| 8HQ1 | X-ray | 4.17 Å | D/E/F=39-557 |
| 8HPY | X-ray | 5.87 Å | D/E=39-557 |
| 5Y31 | X-ray | 7.12 Å | B/D=37-557 |
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