P00735: Prothrombin (F2)

Prothrombin (F2) is a 625-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00735.

Gene

F2

Organism

Bos taurus

Length

625 residues

Mean pLDDT

83.6

Model

AF-P00735-F1 v6

Model created

1 Aug 2025

PDB structures

31

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Model confidence (pLDDT)

The mean pLDDT of this model is 83.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

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Function

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (By similarity). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (By similarity)

Subunit structure

Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin; this interaction does not prevent the activation of prothrombin to thrombin

Subcellular location

Secreted, extracellular space

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

Showing 20 of 31 experimental structures (best resolution first).

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