Transforming growth factor beta-1 proprotein (TGFB1) is a 390-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01137.
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The mean pLDDT of this model is 79.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively
Homodimer; disulfide-linked (PubMed:20207738, PubMed:25209176, PubMed:28117447, PubMed:29109152). Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition (By similarity). May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and…
Secreted, extracellular space, extracellular matrix, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8UDZ | X-ray | 2.21 Å | A/B=30-390 |
| 9VJJ | X-ray | 2.48 Å | A/B=30-390 |
| 8C7H | EM | 2.7 Å | A/C=30-278, B/D=279-390 |
| 6OM2 | X-ray | 2.77 Å | E/F=242-252 |
| 5VQP | X-ray | 2.9 Å | A=30-390 |
| 8REW | EM | 2.98 Å | A/B/C/D=1-390 |
| 3KFD | X-ray | 3.0 Å | A/B/C/D=279-390 |
| 4KV5 | X-ray | 3.0 Å | A/B/C/D=279-390 |
| 8VSC | EM | 3.0 Å | A/B=1-390 |
| 6GFF | X-ray | 3.1 Å | A/C/E/G=30-278, B/D/F/H=279-390 |
| 8VSD | EM | 3.2 Å | E/F=30-390 |
| 7Y1T | EM | 3.24 Å | D=30-390 |
| 9FDY | EM | 3.4 Å | A/B=279-390 |
| 5FFO | X-ray | 3.49 Å | C/D/G/H=34-390 |
| 6P7J | X-ray | 3.5 Å | A=30-278 |
| 9FKP | EM | 3.72 Å | A/B=279-390 |
| 7Y1R | EM | 4.01 Å | A/B=30-390 |
| 1KLA | NMR | A/B=279-390 | |
| 1KLC | NMR | A/B=279-390 | |
| 1KLD | NMR | A/B=279-390 |
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