Interferon alpha-2 (IFNA2) is a 188-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01563.
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The mean pLDDT of this model is 85.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Produced by macrophages, IFN-alpha have antiviral activities
Interacts with IFNAR2
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GVO | X-ray | 1.81 Å | B=24-188 |
| 3S9D | X-ray | 2.0 Å | A/C=24-188 |
| 9GVL | X-ray | 2.01 Å | A/B=24-188 |
| 1RH2 | X-ray | 2.9 Å | A/B/C/D/E/F=24-188 |
| 4YPG | X-ray | 3.0 Å | C/D=24-182 |
| 4Z5R | X-ray | 3.0 Å | D/E/F/G/H/I/N/X=24-188 |
| 3SE3 | X-ray | 4.0 Å | B=24-188 |
| 9GW5 | X-ray | 4.0 Å | A=24-188 |
| 1ITF | NMR | A=24-188 | |
| 2HYM | NMR | B=24-188 | |
| 2KZ1 | NMR | A=24-188 | |
| 2LAG | NMR | A=24-188 | |
| 2LMS | NMR | A=24-188 |
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