Albumin (ALB) is a 609-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02768.
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The mean pLDDT of this model is 92.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By…
Interacts with FCGRT; this interaction regulates ALB homeostasis (PubMed:28330995). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin with molar ratio 1:2 and 1:1; this interaction does not prevent fatty acid binding to ALB (PubMed:9183005)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9IK6 | X-ray | 1.69 Å | A=25-609 |
| 6YG9 | X-ray | 1.89 Å | A=25-609 |
| 1N5U | X-ray | 1.9 Å | A=25-609 |
| 8RCO | X-ray | 1.9 Å | A/B=1-609 |
| 8RCP | X-ray | 1.9 Å | A/B=1-609 |
| 8RGK | X-ray | 1.9 Å | A/B=1-609 |
| 8RGL | X-ray | 1.9 Å | A/B=1-609 |
| 9EOD | X-ray | 1.9 Å | A/B=1-609 |
| 9CSG | X-ray | 1.91 Å | A=27-608 |
| 6QIO | X-ray | 1.95 Å | A=25-609 |
| 9IK7 | X-ray | 1.97 Å | A=25-609 |
| 7VR0 | X-ray | 1.98 Å | A=25-609 |
| 7Y2D | X-ray | 2.0 Å | A=27-607 |
| 8A9Q | X-ray | 2.0 Å | A/B=25-609 |
| 4L8U | X-ray | 2.01 Å | A=25-609 |
| 9ULR | X-ray | 2.01 Å | A=25-609 |
| 7DJN | X-ray | 2.04 Å | A/B=25-609 |
| 3SQJ | X-ray | 2.05 Å | A/B=27-608 |
| 7FFS | X-ray | 2.05 Å | A=25-609 |
| 8Z8V | X-ray | 2.05 Å | A=25-609 |
Showing 20 of 189 experimental structures (best resolution first).
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