8RGL: Human Serum Albumin

Structure of Human Serum Albumin in complex with Aristolochic Acid I at 1.9 A resolution - Optimized. Determined by X-ray diffraction at 1.9 Å resolution. Released 26 Jun 2024.

Method

X-ray diffraction

Resolution

1.9 Å

Organism

Homo sapiens

Chains

2

Atoms

9,972

Mol. weight

142.42 kDa

Ligands

MYR, GOQ

Released

26 Jun 2024

Explore 8RGL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8RGL contains 77 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 0 β-strands

Molecules and chains

>8RGL_1 Serum albumin (chains A, B)
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

Ligands and cofactors

Water and common crystallization additives (EDO) are not listed.

Primary citation

Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin. Pomyalov, S., Minetti, C.A., Remeta, D.P. et al. J Biol Chem (2024) 300:107358-107358. DOI 10.1016/j.jbc.2024.107358 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P02768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 9IK6 1.69 Å, Human Serum Albumin crystallized with T4, pH 6.5
• 6YG9 1.89 Å, Crystal structure of human serum albumin (HSA) in complex with gn-07.
• 1N5U 1.9 Å, X-ray study of human serum albumin complexed with heme
• 8RCO 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution
• 8RCP 1.9 Å, Structure of Human Serum Albumin in complex with Myristic Acid
• 8RGK 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution
• 9EOD 1.9 Å, Human serum albumin with adamantene carboxylic acid
• 9CSG 1.91 Å, Human Serum Albumin Bound to Cerastecin Compound 5e
• 6QIO 1.95 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
• 9IK7 1.97 Å, Human Serum Albumin crystallized with T4, pH 7.5
• 7VR0 1.98 Å, Human Serum Albumin
• 7Y2D 2.0 Å, HSA-Cu agent complex

Browse structure collections

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