7Y2D: HSA-Cu agent complex

HSA-Cu agent complex. Determined by X-ray diffraction at 2.0 Å resolution. Released 5 Jul 2023.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 4,662
Mol. weight: 68.46 kDa
Ligands: IC4, PLM
Released: 5 Jul 2023

Explore 7Y2D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7Y2D contains 40 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 40 helices, 0 β-strands

Element	Residues	Length
α-helix	6-14	9
α-helix	16-30	15
α-helix	36-55	20
α-helix	66-76	11
α-helix	80-84	5
α-helix	86-89	4
α-helix	90-92	3
α-helix	95-104	10
α-helix	113-117	5
α-helix	120-129	10
α-helix	131-145	15
α-helix	151-168	18
α-helix	174-201	28
α-helix	202-206	5
α-helix	208-222	15
α-helix	228-247	20
α-helix	250-266	17
α-helix	268-270	3
α-helix	276-279	4
α-helix	283-291	9
α-helix	293-299	7
α-helix	306	1
α-helix	307-311	5
α-helix	316-321	6
α-helix	323-337	15
α-helix	343-360	18
α-helix	374-376	3
α-helix	378-397	20
α-helix	400-414	15
α-helix	420-437	18
α-helix	442-466	25
α-helix	471-478	8
α-helix	484-490	7
α-helix	491-493	3
α-helix	497-502	6
α-helix	505-507	3
α-helix	511-514	4
α-helix	518-535	18
α-helix	541-559	19
α-helix	564-582	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serum albumin	A	protein	581	Homo sapiens	P02768 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7Y2D_1 Serum albumin (chains A)
HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENC
DKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDV
MCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKL
DELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVH
TECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADL
PSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCA
AADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPT
LVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLV
NRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKE
QLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAAL

Ligands and cofactors

ID	Name	Formula	Copies
IC4	3-chloranyl-13-methoxy-~{N},~{N}-dimethyl-2-oxa-4$l^{3}-thia-6-aza-7-azonia-3$l…	C11 H14 Cl Cu N3 O2 S	2
PLM	Palmitic acid	C16 H32 O2	6

Primary citation

Developing a Copper(II) Agent Based on His-146 and His-242 Residues of Human Serum Albumin Nanoparticles: Integration To Overcome Cisplatin Resistance and Inhibit the Metastasis of Nonsmall Cell Lung Cancer. Jiang, M., Zhang, Z., Li, W. et al. J Med Chem (2022) 65:9447-9458. DOI 10.1021/acs.jmedchem.2c00698 · PubMed

Other PDB entries of the same protein (UniProt P02768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9IK6 1.69 Å, Human Serum Albumin crystallized with T4, pH 6.5
6YG9 1.89 Å, Crystal structure of human serum albumin (HSA) in complex with gn-07.
1N5U 1.9 Å, X-ray study of human serum albumin complexed with heme
8RCO 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution
8RCP 1.9 Å, Structure of Human Serum Albumin in complex with Myristic Acid
8RGK 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution
8RGL 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid I at 1.9 A resolution…
9EOD 1.9 Å, Human serum albumin with adamantene carboxylic acid
9CSG 1.91 Å, Human Serum Albumin Bound to Cerastecin Compound 5e
6QIO 1.95 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
9IK7 1.97 Å, Human Serum Albumin crystallized with T4, pH 7.5
7VR0 1.98 Å, Human Serum Albumin

Browse structure collections

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