9EOD: Albumin

Human serum albumin with adamantene carboxylic acid. Determined by X-ray diffraction at 1.9 Å resolution. Released 26 Mar 2025.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: Homo sapiens
Chains: 2
Atoms: 9,205
Mol. weight: 141.24 kDa
Ligands: A1H6A, MYR
Released: 26 Mar 2025

Explore 9EOD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9EOD contains 76 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 0 β-strands

Element	Residues	Length
α-helix	6-14	9
α-helix	16-30	15
α-helix	36-55	20
α-helix	66-75	10
α-helix	80-84	5
α-helix	85-92	8
α-helix	94	1
α-helix	97-104	8
α-helix	120-129	10
α-helix	131-145	15
α-helix	151-168	18
α-helix	174-206	33
α-helix	208-222	15
α-helix	228-247	20
α-helix	250-266	17
α-helix	268-270	3
α-helix	278-280	3
α-helix	283-291	9
α-helix	293-299	7
α-helix	302-304	3
α-helix	306	1
α-helix	307-311	5
α-helix	315-321	7
α-helix	323-337	15
α-helix	343-360	18
α-helix	366-369	4
α-helix	373-414	42
α-helix	420-438	19
α-helix	442-466	25
α-helix	471-478	8
α-helix	481-490	10
α-helix	497-502	6
α-helix	504-507	4
α-helix	511-514	4
α-helix	518-535	18
α-helix	541-560	20
α-helix	564-582	19

Chain B: 39 helices, 0 β-strands

Element	Residues	Length
α-helix	6-14	9
α-helix	16-30	15
α-helix	36-55	20
α-helix	66-75	10
α-helix	80-84	5
α-helix	86-89	4
α-helix	90-92	3
α-helix	94	1
α-helix	97-104	8
α-helix	113-116	4
α-helix	120-129	10
α-helix	131-145	15
α-helix	151-168	18
α-helix	174-206	33
α-helix	208-222	15
α-helix	228-247	20
α-helix	250-266	17
α-helix	268-270	3
α-helix	276-279	4
α-helix	283-291	9
α-helix	293-299	7
α-helix	302-304	3
α-helix	306	1
α-helix	307-311	5
α-helix	315-321	7
α-helix	323-337	15
α-helix	343-361	19
α-helix	366-369	4
α-helix	373-414	42
α-helix	420-438	19
α-helix	442-466	25
α-helix	471-477	7
α-helix	481-489	9
α-helix	497-502	6
α-helix	504-507	4
α-helix	511-515	5
α-helix	518-535	18
α-helix	541-559	19
α-helix	564-581	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Albumin	A, B	protein	610	Homo sapiens	P02768 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9EOD_1 Albumin (chains A, B)
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGLL

Ligands and cofactors

ID	Name	Formula	Copies
A1H6A	adamantane-1-carboxylic acid	C11 H16 O2	3
MYR	Myristic acid	C14 H28 O2	4

Water and common crystallization additives (PEG, PGE) are not listed.

Primary citation

Human serum albumin with myristate. Freitag-Pohl, S., Pohl, E. To be published.

Other PDB entries of the same protein (UniProt P02768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9IK6 1.69 Å, Human Serum Albumin crystallized with T4, pH 6.5
6YG9 1.89 Å, Crystal structure of human serum albumin (HSA) in complex with gn-07.
1N5U 1.9 Å, X-ray study of human serum albumin complexed with heme
8RCO 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution
8RCP 1.9 Å, Structure of Human Serum Albumin in complex with Myristic Acid
8RGK 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution
8RGL 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid I at 1.9 A resolution…
9CSG 1.91 Å, Human Serum Albumin Bound to Cerastecin Compound 5e
6QIO 1.95 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
9IK7 1.97 Å, Human Serum Albumin crystallized with T4, pH 7.5
7VR0 1.98 Å, Human Serum Albumin
7Y2D 2.0 Å, HSA-Cu agent complex

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