Ferritin heavy chain (FTH1) is a 183-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02794.
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The mean pLDDT of this model is 95.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 93% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293)
Oligomer of 24 subunits (PubMed:9159481). There are two types of subunits: L (light) chain and H (heavy) chain (PubMed:9159481). The major chain can be light or heavy, depending on the species and tissue type. In the human liver, the heavy chain is predominant (PubMed:9159481). The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into…
Cytoplasm, Lysosome, Cytoplasmic vesicle, autophagosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6B8F | X-ray | 1.06 Å | A=2-183 |
| 6B8G | X-ray | 1.13 Å | A=2-183 |
| 7A6A | EM | 1.15 Å | 1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183 |
| 8B7O | X-ray | 1.17 Å | AAA=2-183 |
| 6WYF | X-ray | 1.25 Å | A=2-183 |
| 6Z6U | EM | 1.25 Å | 1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183 |
| 7RRP | EM | 1.27 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177 |
| 7A6B | EM | 1.33 Å | 1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183 |
| 4Y08 | X-ray | 1.34 Å | A=1-183 |
| 7K3V | EM | 1.34 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177 |
| 7K3W | EM | 1.36 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177 |
| 9RGH | X-ray | 1.38 Å | AAA=2-183 |
| 4OYN | X-ray | 1.43 Å | A=1-183 |
| 2CIH | X-ray | 1.5 Å | A=1-183 |
| 9RGJ | X-ray | 1.5 Å | AAA=2-183 |
| 9HQ6 | EM | 1.51 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=2-183 |
| 3AJO | X-ray | 1.52 Å | A=2-183 |
| 4YKH | X-ray | 1.52 Å | A=1-183 |
| 8A5N | X-ray | 1.52 Å | AAA=2-183 |
| 9JGP | X-ray | 1.53 Å | A=2-183 |
Showing 20 of 145 experimental structures (best resolution first).
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