Polymerase basic protein 2 (PB2) is a 759-residue protein from Influenza A virus. This is its AlphaFold structure prediction, created 3 Sept 2026. UniProt accession: P03428.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 74.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 70% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus) (PubMed:28169297). Interacts with nucleoprotein NP (via N-terminus) (PubMed:22570712, PubMed:25043584). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response (PubMed:20538852, PubMed:23246644)
Virion, Host nucleus, Host mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4U6O | X-ray | 1.3 Å | A/B=318-483 |
| 4ENF | X-ray | 1.32 Å | A=318-483 |
| 3A1G | X-ray | 1.7 Å | B/D=1-37 |
| 3WI1 | X-ray | 1.93 Å | A=318-484 |
| 3WI0 | X-ray | 2.0 Å | A=318-484 |
| 2ZTT | X-ray | 2.1 Å | B/D=1-37 |
| 4J2R | X-ray | 2.42 Å | A/B=318-484 |
| 3CW4 | X-ray | 2.7 Å | A=535-759 |
| 7JYW | X-ray | 2.9 Å | C=549-557 |
| 7JYX | X-ray | 2.95 Å | C/F=549-559 |
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