von Willebrand factor (VWF) is a 351-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04275.
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The mean pLDDT of this model is 75.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma
Multimeric. Interacts with F8
Secreted, Secreted, extracellular space, extracellular matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5BV8 | X-ray | 1.59 Å | A=1238-1471 |
| 7EOW | X-ray | 1.6 Å | A=1261-1468 |
| 3ZQK | X-ray | 1.7 Å | A/B/C=1477-1674 |
| 1ATZ | X-ray | 1.8 Å | A/B=1685-1873 |
| 1IJB | X-ray | 1.8 Å | A=1263-1464 |
| 2ADF | X-ray | 1.9 Å | A=1683-1874 |
| 3GXB | X-ray | 1.9 Å | A/B=1495-1671 |
| 3PPV | X-ray | 1.9 Å | A=1488-1674 |
| 3PPW | X-ray | 1.9 Å | A=1488-1674 |
| 3PPX | X-ray | 1.91 Å | A=1488-1674 |
| 1FNS | X-ray | 2.0 Å | A=1271-1465 |
| 3PPY | X-ray | 2.0 Å | A=1488-1674 |
| 1FE8 | X-ray | 2.03 Å | A/B/C=1683-1874 |
| 4C2A | X-ray | 2.08 Å | A=1264-1471 |
| 7F49 | X-ray | 2.09 Å | A=1259-1468 |
| 1AO3 | X-ray | 2.2 Å | A/B=1686-1872 |
| 1OAK | X-ray | 2.2 Å | A=1270-1465 |
| 4C29 | X-ray | 2.2 Å | A/B=1264-1471 |
| 1AUQ | X-ray | 2.3 Å | A=1261-1468 |
| 3HXO | X-ray | 2.4 Å | A=1260-1468 |
Showing 20 of 48 experimental structures (best resolution first).
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