Interleukin-4 (IL4) is a 153-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05112.
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The mean pLDDT of this model is 86.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727). Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:1993171). Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (PubMed:2521231). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.…
Interacts with IL4R (PubMed:10219247, PubMed:11526337). Interacts with IL13RA1 (PubMed:18243101)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2D48 | X-ray | 1.65 Å | A=25-153 |
| 2B8X | X-ray | 1.7 Å | A=25-153 |
| 2B8U | X-ray | 1.8 Å | A=25-153 |
| 2B8Y | X-ray | 1.8 Å | A=25-153 |
| 2B91 | X-ray | 2.0 Å | A=25-153 |
| 4YDY | X-ray | 2.0 Å | I/J=25-153 |
| 1HZI | X-ray | 2.05 Å | A=25-153 |
| 2B90 | X-ray | 2.1 Å | A=25-153 |
| 1RCB | X-ray | 2.25 Å | A=25-153 |
| 1IAR | X-ray | 2.3 Å | A=25-153 |
| 2INT | X-ray | 2.35 Å | A=25-153 |
| 2B8Z | X-ray | 2.5 Å | A=25-153 |
| 5FHX | X-ray | 2.55 Å | A=30-153 |
| 1HIK | X-ray | 2.6 Å | A=25-153 |
| 3BPL | X-ray | 2.93 Å | A=25-153 |
| 1HIJ | X-ray | 3.0 Å | A=25-153 |
| 3BPN | X-ray | 3.02 Å | A=25-153 |
| 6OEL | X-ray | 3.1 Å | A=25-153 |
| 3QB7 | X-ray | 3.24 Å | A/B=25-153 |
| 1BBN | NMR | A=22-153 |
Showing 20 of 29 experimental structures (best resolution first).
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