Alpha-2A adrenergic receptor (ADRA2A) is a 465-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08913.
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The mean pLDDT of this model is 70.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:2170371, PubMed:23105096, PubMed:2568356, PubMed:35245122, PubMed:27376152). Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2568356, PubMed:27376152). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6KUX | X-ray | 2.7 Å | A=35-460 |
| 9PLO | EM | 2.74 Å | R=2-465 |
| 9CBL | EM | 2.8 Å | R=35-460 |
| 9PLN | EM | 2.8 Å | R=2-465 |
| 7EJ8 | EM | 3.0 Å | R=1-465 |
| 6KUY | X-ray | 3.2 Å | A=35-460 |
| 7EJ0 | EM | 3.2 Å | R=1-465 |
| 9CBM | EM | 3.2 Å | R=35-460 |
| 9PQD | EM | 3.29 Å | R=2-465 |
| 7EJK | EM | 3.4 Å | R=1-465 |
| 7W7E | EM | 3.4 Å | R=1-465 |
| 9IQR | EM | 3.4 Å | B=38-456 |
| 7W6P | EM | 3.47 Å | R=1-465 |
| 7EJA | EM | 3.6 Å | R=1-465 |
| 6K42 | EM | 4.1 Å | R=37-44 |
| 1HLL | NMR | A=133-164 | |
| 1HO9 | NMR | A=133-164 | |
| 1HOD | NMR | A=133-164 | |
| 1HOF | NMR | A=133-164 |
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