Myosin light chain kinase, smooth muscle (Mylk) is a 1906-residue protein from Gallus gallus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11799.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 65.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals
All isoforms including Telokin bind calmodulin
Cytoplasm, Cell projection, lamellipodium, Cleavage furrow, Cytoplasm, cytoskeleton, stress fiber, Cytoplasm, cytosol, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2O5G | X-ray | 1.08 Å | B=1730-1748 |
| 1QTX | X-ray | 1.65 Å | B=1731-1749 |
| 3EVU | X-ray | 1.75 Å | A=1731-1749 |
| 1QS7 | X-ray | 1.8 Å | B/D=1731-1750 |
| 9U9D | X-ray | 1.8 Å | A=1726-1775 |
| 3EK7 | X-ray | 1.85 Å | A=1730-1763 |
| 1VRK | X-ray | 1.9 Å | B=1731-1749 |
| 1CDL | X-ray | 2.0 Å | E/F/G/H=1730-1749 |
| 3EKH | X-ray | 2.0 Å | A=1730-1763 |
| 3EVR | X-ray | 2.0 Å | A=1730-1763 |
| 4OY4 | X-ray | 2.03 Å | A=1719-1725, A=1745-1749 |
| 3O77 | X-ray | 2.35 Å | A=1730-1749 |
| 3EVV | X-ray | 2.6 Å | A=1731-1749 |
| 3O78 | X-ray | 2.6 Å | A/B=1731-1749 |
| 3EK8 | X-ray | 2.8 Å | A=1730-1763 |
| 3EKJ | X-ray | 2.8 Å | A=1730-1763 |
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